Urinary steroids in young women with eating disorders

Poór, Viktória; Bíró, Ildikó; Bufa, Anita; Gáti, Ágnes; Fenyvesi, Ilona; Juricskay, S.; Tényi, Tamás; Kilár, Ferenc

doi:10.1016/j.jbbm.2004.09.004

Cited by 5 publications

(8 citation statements)

References 31 publications

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“…In the last few years, we have examined the steroid profile of patients with hair (AA in both sexes, EE in women) [7-9] and psychiatric problems (MD in both sexes, EDS in women) [10,11] and OP (in women) [12].…”

Section: Resultsmentioning

confidence: 99%

“…The main role in this process is assigned to the scalp skin [15] while the elevated levels of DHEA (AA in women, E) and 16-OH-DHEA (AA in men and women, E) indicate the involvement of adrenal steroids in these diseases [7][8][9]. Unlike in MD in women (p<0.01) and in EDS, (p<0.05) significantly decreased levels of DHEA were found [10,11], which are consistent with other's finding on saliva or serum [16][17][18][19][20][21][22]. Knowing the anti-depressant effects of the DHEA [23,24], this finding suggests DHEA treatment in these cases.…”

Section: Methodsmentioning

confidence: 99%

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Urinary Steroid Measurements in Some Endocrine and Psychiatric Diseases

Poór

Bufa

Bíró

et al. 2005

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In 1990, the worldwide accepted Shackleton method, which provides a possibility of determining the steroid metabolites from urine, was adopted in our laboratory. The procedure is very useful in the diagnosis of different endocrine diseases and in the recognition of dysfunction or absence of enzymes with an important role in steroid metabolism, and it gives possibility to control the treatment in patients with these diseases. Besides the proximate clinical application, the method gives a convenient tool to study the steroid background of these disorders, helping us understand the mechanism of their development. In the last few years, we have examined the steroid profile of patients with hair (androgen alopecia /AA/, effluvium /E/), psychiatric problems (major depression /MD/, eating disorders /EDS/, especially anorexia nervosa and bulimia) and osteoporosis (OP). In all of the examined hair loss diseases, the levels of main androgen metabolites were increased, and elevated 5alpha-reductase activity were found. We could observe the alteration of the activity of 11beta-hydroxysteroid dehydrogenase (11beta-HSD) enzyme and marked gender differences in the changes of the steroid metabolism in patients with major depression (MD). In women with OP, the significantly decreased level of certain metabolites points to the role of testosterone, androstenedione and DHEA in postmenopausal bone loss in women. Our experiences contribute to the knowledge of the nature and steroid background of some endocrine and psychiatric diseases.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Urinary Steroid Measurements in Some Endocrine and Psychiatric Diseases

Poór

Bufa

Bíró

et al. 2005

CMC

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show abstract

“…Therefore, enzymatic hydrolysis has to be applied to determine total amounts of urinary glucocorticoids. The incubation with ␤-glucuronidase from Helix pomatia was provided at 37 • C but the time differed in published methods from overnight incubation [18] to 48 h [19,25]. It was suggested that the same yield of hydrolysis can be achieved in time of 2-3 h raising the temperature of incubation to 55 • C [39].…”

Section: Compoundmentioning

confidence: 99%

“…1C). However, in the literature most often only THE is considered as metabolite of E. The level of allo-THE is passed over [6,10,12,[19][20][21][22][23][24][25][26][27][28]39]. The reason of such simplification may be much lower level of allo-THE in comparison to THE in urine [42] or difficulties in effective separation of those isomers.…”

Section: Specificitymentioning

confidence: 99%