Urinary styrene in the biological monitoring of styrene exposure.

Gobba, Fabriziomaria; Galassi, Claudia; Ghittori, S; Imbriani, Marcello; Pugliese, Fabrizio; Cavalleri, A.

doi:10.5271/sjweh.1484

Cited by 32 publications

(18 citation statements)

References 27 publications

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“…In a previous study in a similar workplace (14) enviro11me11-tal airborne levels of acetone were always low, never exceeding 500 mg . m-3 in several spot samples collected during different moments of the workday, including tool cleaning.…”

Section: Discussionmentioning

confidence: 67%

“…As indicated by the results of the biological monitoring, the occupational exposure of one of the two workers (PL) was about 20-50% higher than the biological limits adopted for styrene in the United States (5,14). The values obtained for the other worlter (CC) were closer to the limit, but the symptoms appeared at the end of a period of increased production of fiber-glass reinforced plastics products, and therefore possibly resulted in increased exposure.…”

Section: Discussionmentioning

confidence: 80%

See 1 more Smart Citation

Peripheral neuropathy in styrene-exposed workers

Gobba¹,

Cavalleri²,

Bontadi³

et al. 1995

Scand J Work Environ Health

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BackgroundThe toxicity of styrene on the peripheral nervous system is still debated. Cases The paper presents two cases of peripheral se~lsorirnotor neuropathy in styrene-exposed workers. Exposure, evaluated by biological monitoring, ranged between 100 and 150% of the current linlits proposed by the American Conference of Governme~ltal Industrial Hygienists (ACGIH). The subjects complained of leg weakness and numbness, cramps, and paresthesia. Electrophysiology revealed a moderate peripheral sensorimotor neuropathy of a deinyelinating type. Color-vision testing showed a subclinical deficit. Cornmon inherited and acquired causes of peripheral ~leuropathy and dyschromatopsia other than styrene were ruled out by personal history, medical examination, laboratory data, and chest X-ray. C O~C~U S~O~S The results suggest that long-term occupational exposure to e~lviro~lmental levels of styrene that are equal, or slightly above, the ACGIH limits can induce a clinical form of peripheral neuropathy and a subclinical impairment of color vision. As a consequence, a careful reappraisal of the real preventive meaning of the current ACGIH occupational limit for styrene, at least on an individual basis, is needed.

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Section: Discussionmentioning

confidence: 67%

Section: Discussionmentioning

confidence: 80%

Peripheral neuropathy in styrene-exposed workers

Gobba¹,

Cavalleri²,

Bontadi³

et al. 1995

Scand J Work Environ Health

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show abstract

“…The internal dose of styrene was evaluated by measuring the urinary excretion of unmodi®ed styrene (StU), a speci®c and sensitive index [9,10]. A further advantage is that StU can evaluate exposure during periods shorter than a whole work-shift, as demonstrated in 214 workers exposed to styrene concentrations ranging from 5 to 900 mg/m 3 : the correlation found during one half-shift between environmental St and values of StU in samples of urine formed during the corresponding period was r 0.82 in the morning halfshift and r 0.87 in the afternoon half-shift (P < 0.01) [9].…”

Section: Introductionmentioning

confidence: 99%

“…A further advantage is that StU can evaluate exposure during periods shorter than a whole work-shift, as demonstrated in 214 workers exposed to styrene concentrations ranging from 5 to 900 mg/m 3 : the correlation found during one half-shift between environmental St and values of StU in samples of urine formed during the corresponding period was r 0.82 in the morning halfshift and r 0.87 in the afternoon half-shift (P < 0.01) [9]. Similar results were found in other groups of Stexposed workers [7,8,10,11].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of half-mask respirator protection in styrene-exposed workers

Gobba¹,

Ghittori

Imbriani

et al. 2000

Int Arch Occup Environ Health

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The protection afforded by negative-pressure half-mask respirators varies widely, which stresses the need to assess the effective reduction of exposure whenever these devices are introduced for St-exposed workers. If respirators are to be re-used for several days, their performance must be evaluated during the last shift of use. Measurement of urinary excretion of unmodified St proved a useful tool for the evaluation of respirator effectiveness in exposed workers.

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“…With the improvement of analytical methods, unmetabolized VOCs in urine were again paid much attention from 1990 onwards, mainly by Japanese researchers. Good correlations between air and urinary toluene, xylenes and styrene have been reported in occupational environments with over 0.1 ppm solvent exposure [12][13][14][15][16][17][18][19][20][21][22][23] . 6) .…”

mentioning

confidence: 99%

Unmetabolized VOCs in Urine as Biomarkers of Low Level Exposure in Indoor Environments

Wang

Takigawa

Takeuchi

et al. 2007

Journal of Occupational Health

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Unmetabolized VOCs in Urine as (VOCs) in urine as biomarkers of low-level indoor environmental exposure. Twenty-four subjects in 13 dwellings in a prefecture of Japan participated in this study. Air samples of the breathing zone were collected in the living room and bedroom, along with spot urine samples (before bedtime and first morning voids). Toluene, ethylbenzene, xylene isomers, styrene and pdichlorobenzene in the air and urine samples were measured by gas chromatography/mass spectrometry. For the 21 subjects without solvent exposure at work, there were significant correlations between the timeweighted average air concentrations in the bedroom and morning urinary concentrations for toluene, oxylene, total xylene and p-dichlorobenzene (correlation coefficients of 0.54, 0.61, 0.56 and 0.84, respectively). Multiple linear regression analysis showed only air VOCs in the bedroom influenced the morning urinary VOC concentrations. We concluded that unmetabolized VOCs in the urine can provide a reliable biological indicator for air VOC exposures in non-occupational environments. (J Occup Health 2007; 49: 104-110)

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Urinary styrene in the biological monitoring of styrene exposure.

Cited by 32 publications

References 27 publications

Peripheral neuropathy in styrene-exposed workers

Peripheral neuropathy in styrene-exposed workers

Evaluation of half-mask respirator protection in styrene-exposed workers

Unmetabolized VOCs in Urine as Biomarkers of Low Level Exposure in Indoor Environments

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