Urinary Total, Aqueous, and Ether-Soluble Porphyrins

Schlenker, Frank S.; Davis, Cora L.; Kitchell, Cynthia L.

doi:10.1093/ajcp/39.5_ts.531

Cited by 2 publications

(1 citation statement)

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“…None of the workers examined was suffering from frank clinical plumbism, but in one case of lead poisoning examined by Schlenker (1964) the level of amino-acetone was found to be slightly decreased and those of delta-aminolaevulinic acid and porphobilinogen were elevated. The finding of raised amino-acetone levels amongst some of the lead workers was unexpected in the light of enzymatic studies performed in animals by Tschudy (1964) who was of the opinion, as a result of this work, that lead would be unlikely to increase excretion of amino-acetone.…”

Section: Methodsmentioning

confidence: 94%

Urinary amino-acetone excretion in lead workers

Waldron

1965

Journal of Clinical Pathology

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SYNOPSIS Urinary amino-acetone concentrations were determined in a group of 51 persons with industrial exposure to lead and the findings compared with those obtained from a control group of 27 persons having no exposure to lead.A good correlation was found between delta-aminolaevulinic acid and amino-acetone excretion in the control group but this correlation was not so well defined in the lead-exposed group. In this group excretion of amino-acetone seemed to be better correlated with excretion of delta-aminolaevulinic acid for values less than 0-6 mg. % than with values greater than 0-6 mg. %. All the men concerned in the investigation were employed in dusty occupations. Hypotheses are put forward to attempt to explain the differences in excretion of amino-acetone noted amongst lead workers with high excretion of delta aminolaevulinic acid.Little correlation was found between amino-acetone excretion and that of either porphobilinogen or coproporphyrin.

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Section: Methodsmentioning

confidence: 94%