Urinary tract abnormalities in Chinese rural children who consumed melamine-contaminated dairy products: a population-based screening and follow-up study

The Clinical Profile and Prognosis of Chinese Children with Melamine-Induced Kidney Disease: A Systematic Review and Meta-Analysis

“…The 26 studies, involving a total of 2164 patients, were conducted in 11 different provincial administrative areas of China, comprising 10 [14–17, 19–23, 38] published in English and 16 [18, 24–37, 39] in Chinese. The diagnosis and treatment of patients in all these 26 studies were according to the same standard recommended by the Chinese Ministry of Health [4].…”

“…Of these 26 studies, 12 [17, 18, 20, 21, 23, 24, 27, 30, 32, 33, 35, 38] were population-based and 14 [14–16, 19, 22, 25, 26, 28, 29, 31, 34, 36, 37, 39] were hospital-based; 3 [24, 27, 30] studies had a loss to follow-up rate ≥15%, 8 [14, 18, 22, 32–34, 37, 38] had a loss to follow-up rate ranging from 1% to 14%, and the remaining 15 [15–17, 19–21, 23, 25, 26, 28, 29, 31, 35, 36, 39] studies reported no loss to followup. In total, 22 were assessed to be of high quality [14–23, 25–32, 35–38] and 4 of low quality [24, 33, 34, 39].…”

“…Of the 26 studies, 13 [15, 17, 19, 24, 26–29, 31, 32, 34, 38, 39] reported the range of the calculi diameter, and the minimum diameter was 1 mm and the maximum 33 mm; 13 [15, 17–19, 23, 25, 26, 28, 32, 34–36, 38] reported the percentage of patients with calculi diameter ≤10 mm, and the pooled percentage was 95.5%. Of the 26 studies, 16 [14–17, 20–23, 25–28, 30–32, 38] clearly stated the clinical manifestation of patient, and the percent of asymptomatic patients ranged from 0 to 99.4%; the pooled percentage of asymptomatic patients was 76.2%.…”

Nephrolithiasis screening for people with self-perceived exposure to melamine-contaminated milk products in Taipei County, Taiwan

“…7,8 After 6 months of follow-up, about 90% of patients were stone-free, and no more abnormal structures were observed by ultrasonography examination. 7,9 In some severe cases with acute obstructive renal failure, hemodialysis was required to correct biochemical anomalies or surgical interventions were performed to remove stones. Since the outbreak of renal diseases caused by MCMPs was first reported by the media on September 11, 2008, many NSPs have been launched in mainland China, Hong Kong, and Taiwan, with most of them focused on children and infants.…”

Reprint of “Decision support for risks managers in the case of deliberate food contamination: The dairy industry as an example”

“…Nevertheless, we expect that contamination of milk in dairy plants is less likely than in farms due to restricted access to the dairy plants. Relevant characteristics of milk, the kind of biological agents or toxins, individual dispositions like the age of people [34][35][36][37] and internal processes like pasteurization [38][39][40][41][42][43], which may influence the vulnerability of the consumers to contamination, but also the spread of contamination [32], are not considered in this paper.…”