Urinary Tract Infection

Torpy, Janet M.; Schwartz, Laura; Golub, Robert M.

doi:10.1001/jama.2012.3885

Cited by 9 publications

(7 citation statements)

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“…In our study, although education was a key component, other components were lacking to address the main barriers determined during the process evaluation. Thus, the benefits of performing a process evaluation are that in cases such as in our study where despite the evidence that this protocol worked in another setting (Lo et al, 2014;Torpy et al, 2012), and did not work at our hospital we can gain insight into why this was the case.…”

Section: Comparison To Previous Researchmentioning

confidence: 89%

Intervention to reduce unnecessary urinary catheter use in a large academic health science centre: A one‐group, pretest, posttest study with a theory‐based process evaluation

et al. 2021

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Aim To evaluate an intervention to reduce unnecessary urinary catheter use and prevent catheter‐associated urinary‐tract infections (CAUTI) in hospitalized patients across an academic health science centre. Methods We conducted a one‐group, pretest, posttest study with a theory‐based process evaluation. Phase 1 consisted of a pre/postintervention to test the impact of a CAUTI protocol. Audits on four units were conducted, and data were analysed descriptively. Phase 2 consisted of a theory‐based process evaluation to understand the barriers/enablers to the implementation. Semistructured interviews were conducted and then analysed using a systematic approach. Results In Phase 1, all inpatients with urinary catheters admitted to the units (N = 4) during the study period (N = 99, pre) and (N = 99, post) were included. CAUTI prevalence rate was 18.2% pre versus 14.1% post (p = .563). In Phase 2, participants (N = 18) who worked on the units were interviewed, and a total of 13 barriers and 19 enablers were found.

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Section: Comparison To Previous Researchmentioning

confidence: 89%

Intervention to reduce unnecessary urinary catheter use in a large academic health science centre: A one‐group, pretest, posttest study with a theory‐based process evaluation

et al. 2021

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“…To further explore the quantitative detection potential of the designed array, E. coli and P. aeruginosa, the most prevalent bacteria in UTI, were selected for bacterial concentration discrimination. [16] The fluorescence intensity changes of the 12-channel array for various concentrations (OD 600 = 0.2, 0.1, 0.05, 0.01, 0.005, and 0.001) of E. coli and P. aeruginosa were collected (Figure 3A, Figure S33A). These changes in fluorescence exhibited a positive correla-tion with bacterial concentration.…”

Section: Forschungsartikelmentioning

confidence: 99%

A Dual Fluorescence Turn‐On Sensor Array Formed by Poly(para‐aryleneethynylene) and Aggregation‐Induced Emission Fluorophores for Sensitive Multiplexed Bacterial Recognition

Yu,

Ni,

et al. 2024

Angewandte Chemie

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Bacterial infections have emerged as the leading causes of mortality and morbidity worldwide. Array‐based sensing methods provide significant advantages for the simultaneous detection of multiple bacteria, thereby offering immense potential for the prompt diagnosis of infectious diseases. However, the detection of multiple bacteria at low concentrations to meet clinical testing requirements remains exceptionally challenging. Herein, we developed a dual‐channel fluorescence "turn‐on" sensor array, comprising six electrostatic complexes formed from one negatively charged poly(para‐aryleneethynylene) (PPE) and six positively charged aggregation‐induced emission (AIE) fluorophores. The 6‐element array enabled the simultaneous identification of 20 bacteria (OD600 = 0.005) within 30s (99.0% accuracy), demonstrating significant advantages over the array constituted by the 7 separate elements that constitute the complexes. Meanwhile, the array realized different mixing ratios and quantitative detection of prevalent bacteria associated with urinary tract infection (UTI). It also excelled in distinguishing six simulated bacteria samples in artificial urine. Remarkably, the limit of detection for E. coli and E. faecalis was notably low, at 0.000295 and 0.000329 (OD600), respectively. Finally, optimized by diverse machine learning algorithms, the designed array achieved 96.7% accuracy in differentiating UTI clinical samples from healthy individuals using a random forest model, demonstrating the great potential for medical diagnostic applications.

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“…Phase 2 was put in place as a theory-based process evaluation to help us improve the implementation process, whether it was successful or not. The bene t of performing a process evaluation is that in cases such as this where despite the evidence that this protocol worked in another setting [26,27], and did not work at our hospital we can gain insight into why this was the case.…”

Section: Summary Of the Ndingsmentioning

confidence: 99%

Intervention to reduce unnecessary urinary catheter use in a large academic health science centre: A theory-based process evaluation

Backman

Wooller

Hasimja-Saraqini

et al. 2020

Preprint

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Background: Inappropriate use of urinary catheters can increase the risk of catheter-associated urinary tract infections (CAUTI) leading to increased morbidity and increased costs. The overall purpose of this study was to evaluate an intervention to reduce unnecessary urinary catheter use and prevent CAUTI in hospitalized patients across a large academic health science centre. Methods: This was a two-phase study, which took place between 2017 and 2019. Phase 1 was a pre- and post-intervention design to test the impact of a CAUTI protocol across the organization. Audits on 4 units pre and post were conducted, and data were analyzed descriptively. Phase 2 was a theory-based process evaluation to understand the barriers and enablers to the implementation. Semi-structured interviews were conducted and then analyzed using a systematic approach. Results: Phase 1: All inpatients with urinary catheters admitted on the four selected units during the study period (n=99, pre) and (n=99, post) were included. CAUTI prevalence rate was 18.2% pre vs 14.1% post (p=.563). Phase 2: participants (n=18) who worked during the study period on the four audit units were interviewed, and a total of 13 barriers and 19 enablers were found across the participant groups. Conclusion: No statistically significant difference in CAUTI prevalence rates were noted. The theory-based process evaluation provided insights into barriers and enablers to the implementation which may help reformulate the intervention in the future.

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Urinary Tract Infection

Cited by 9 publications

References 0 publications

Intervention to reduce unnecessary urinary catheter use in a large academic health science centre: A one‐group, pretest, posttest study with a theory‐based process evaluation

Intervention to reduce unnecessary urinary catheter use in a large academic health science centre: A one‐group, pretest, posttest study with a theory‐based process evaluation

A Dual Fluorescence Turn‐On Sensor Array Formed by Poly(para‐aryleneethynylene) and Aggregation‐Induced Emission Fluorophores for Sensitive Multiplexed Bacterial Recognition

Intervention to reduce unnecessary urinary catheter use in a large academic health science centre: A theory-based process evaluation

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