Urinary tract infection among fistula patients admitted at Hamlin fistula hospital, Addis Ababa, Ethiopia

Abstract

BackgroundUrinary Tract Infection (UTI) causes a serious health problem and affects millions of people worldwide. Patients with obstetric fistula usually suffer from incontinence of urine and stool, which can predispose them to frequent infections of the urinary tract. Therefore the aim of this study was to determine the etiologic agents, drug resistance pattern of the isolates and associated risk factor for urinary tract infection among fistula patients in Addis Ababa fistula hospital, Ethiopia.MethodsAcross sectional study was conducted from February to May 2015 at Hamlin Fistula Hospital, Addis Ababa, Ethiopia. Socio-demographic characteristics and other UTI related risk factors were collected from study participants using structured questionnaires. The mid-stream urine was collected and cultured on Cysteine lactose electrolyte deficient agar and blood agar. Antimicrobial susceptibility was done by using disc diffusion method and interpreted according to Clinical and Laboratory Standards Institute (CLSI). Data was entered and analyzed by using SPSS version 20.ResultsOut of 210 fistula patients investigated 169(80.5%) of the patient were younger than 25 years. Significant bacteriuria was observed in 122/210(58.1%) and 68(55.7%) of the isolates were from symptomatic cases. E.coli 65(53.7%) were the most common bacterial pathogen isolated followed by Proteus spp. 31(25.4%). Statistical Significant difference was observed with history of previous UTI (P = 0.031) and history of catheterization (P = 0.001). Gram negative bacteria isolates showed high level of resistance (>50%) to gentamicin and ciprofloxacin, while all gram positive bacteria isolated were showed low level of resistance (20–40%) to most of antibiotic tested.ConclusionsThe overall prevalence of urinary tract infection among fistula patient is 58.1%. This study showed that the predominant pathogen of UTI were E.coli followed by Proteus spp. It also showed that amoxicillin-clavulanic acid was a drug of choice for urinary tract bacterial pathogens.

Non-Fistulous Complications of Prolonged Obstructed Labour among Obstetric Fistula Patients in Southern Nigeria

“…Urinary tract infection was seen in 61.5% of participants. The proportion of women with UTI is much higher than 26.2% reported in Sokoto [16], but similar to findings of 52.8% and 58.1% in Ethiopia [28] [29]. Circumferential defect, urethral involvement and extensive vaginal scarring predict poor prognosis of surgical outcomes of obstetric fistula repair [30] [31].…”

Antibiotic Susceptibility and Molecular Characterization of Uropathogenic Escherichia coli Associated with Community-Acquired Urinary Tract Infections in Urban and Rural Settings in South Africa

“…Escherichia coli is the most common occurring uropathogen in UTIs [ 31 , 32 , 33 , 34 ], accounting for 75–95% of all CA-UTIs reported globally [ 33 ]. These reports corroborate the finding of the current study in which over 80% of isolates obtained from the cultured urine samples were E. coli .…”

Prevalence of Antibiotic Resistance in Escherichia coli from the Fecal Flora of Humans in a Rural Area of Songkhla Province

“…When compared with the rural areas of other countries such as Korea, Philippines, India, Venezuela, Mexico, Peru, Kenya, Ghana Zimbabwe and Etiopia [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27] , the maximum levels of resistance were found in amoxicillin and oxytetracycline. The highest maximum levels of resistance in urban areas were found in amoxicillin, oxytetracycline, and trimethoprim.…”