Urinary Tract Infection in Infants: A Single-Center Clinical Analysis in Southern Taiwan

Abstract

E coli was the most common pathogen in the present cohort, and the top three pathogens were similar to those found in general pediatric population in Taiwan. VUR was the most common genitourinary tract anomaly in this age group. Positive DMSA was well correlated with VUR and higher C-reactive protein level.

Infants under two months of age with urinary tract infections are showing increasing resistance to empirical and oral antibiotics

“…A significant proportion of UTIs in the infants in our study were caused by GNBs that were resistant to several antibiotic classes and 11.8% were MDR. The resistance rate was higher in our cohort than in other studies that have described the antimicrobial resistance of GNB causing UTIs in this age group (Table 1) (12)(13)(14)(15)(16)(17)(18). In our study, 7% of the GNBs were not susceptible to gentamicin and to the empirical protocol.…”

The Distribution of Beta Lactamase Genes in Escherichia Coli Phylotypes Isolated from Diarrhea and UTI Cases in Northwest Iran

“…Most of the isolates in the present study were resistant to multiple antibiotic groups. High resistance to common antibiotics has also been reported in previous studies [7,11,26]. The present study offers the first characterization of TEM-type and SHV-type ESBL variants produced by E. coli circulating in hospitals in Hamadan (northwest Iran).…”

Comparison of Acute Lobar Nephronia and Acute Pyelonephritis in Children: A Single-Center Clinical Analysis in Southern Taiwan

“…Urine cultures were performed in 157 patients (79 in the ALN Compared with the APN group, E. coli isolated from the urine cultures in the ALN group had a similarly high resistance rate to ampicillin (68% vs. 62%, p Z 0.57), but a higher resistance rate to trimethoprimesulfamethoxazole (59% vs. 27%, p Z 0.004) and piperacillin (77% vs. 54%, p Z 0.027). Although we used cefazolin and/or gentamicin as the empirical therapy for pediatric UTI from 2000, 15,16 the resistance rate to cefazolin (24% in ALN vs. 21% in APN, p Z 0.611) and gentamicin (27% in ALN vs. 24% in APN, p Z 0.626) did not increase significantly. Only three patients (2 in the ALN group and 1 in the APN group) with E. coli isolated from their urine cultures had resistance to both cefazolin and gentamicin.…”

“…Similar to our ALN patients, a prevalence rate of 4.4% of ESBL-producing E. coli strains in UTI of infants aged < 4 months was reported in our hospital from 2001 to 2009. 15 It seems that ESBL E. coli is not related to severity of UTI. However, few samples of ESBL E. coli were present in our series.…”