2020
DOI: 10.20944/preprints202004.0376.v1
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Urinary Tract Infection in Patients with Multiple Sclerosis: An Overview

Abstract: Introduction: Multiple sclerosis (MS) is a demyelinating, chronic, inflammatory and autoimmune disease of the central nervous system (CNS) with axonal degeneration, presenting a progressive and variable course. MS patients usually have complications, such as bladder dysfunction, presence of urinary symptoms and Urinary Tract infection (UTI), which is one of the three most common non-neurological complications in MS patients. Objective: Analyze the most diverse aspects of UTI in MS patients, focusing on risk fa… Show more

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Cited by 4 publications
(5 citation statements)
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“…Our findings reveal a 10-fold increase in the incidence of urinary tract infections and cases of urosepsis among people with MS. This pronounced difference can be attributed to the welldocumented association between MS and bladder dysfunction affecting up to 70% of people with MS, which significantly elevates the susceptibility to urinary tract infections (16,17). Admission due to pneumonia was also more than three times as frequent among people with MS than in the controls from the general population.…”
Section: Acute Hospital Admissionsmentioning
confidence: 99%
“…Our findings reveal a 10-fold increase in the incidence of urinary tract infections and cases of urosepsis among people with MS. This pronounced difference can be attributed to the welldocumented association between MS and bladder dysfunction affecting up to 70% of people with MS, which significantly elevates the susceptibility to urinary tract infections (16,17). Admission due to pneumonia was also more than three times as frequent among people with MS than in the controls from the general population.…”
Section: Acute Hospital Admissionsmentioning
confidence: 99%
“…Patients with autoimmune diseases, such as MS, are often treated with immunomodulatory drugs that may increase their susceptibility to infection and sepsis. For example, urinary tract infection and respiratory infection are both common causes of sepsis (22) and complications for MS patients, relative to the general population (23,24). In fact, compared with the general healthy population, individuals with MS are at greater risk of sepsis, sepsis-induced complications, and death because of infection (25).…”
Section: Introductionmentioning
confidence: 99%
“…Urinary tract infection (UTI) aggravates neurological symptoms in MS patients. It is both one of the main factors leading to pseudorelapse and one of the main causes of mortality and morbidity in MS patients [ 8 13 ]. UTI refers to the occurrence of fever, chills, dysuria, frequent urination, suprapubic pain, and pathologic urinalysis or positive culture [ 10 ].…”
Section: Introductionmentioning
confidence: 99%
“…UTI refers to the occurrence of fever, chills, dysuria, frequent urination, suprapubic pain, and pathologic urinalysis or positive culture [ 10 ]. Factors such as sphincter dysfunction, female gender, incomplete bladder depletion, and constant or occasional use of a urinary catheter augment the risk of this infection in people with MS [ 13 15 ]. Also, the longer the MS duration and the higher the Expanded Disability Status Scale (EDSS) score, the greater the risk of UTI in these patients [ 14 ].…”
Section: Introductionmentioning
confidence: 99%