Urinary tract infection in patients with diabetes mellitus

Fünfstück, R; Nicolle, Lindsay E.; Hanefeld, Markolf; Naber, Kurt G.

doi:10.5414/cn107216

Cited by 109 publications

(103 citation statements)

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“…The role of IGF-I in the development of bladder cancer was also evaluated via in vivo studies which demonstrated similar results (Dunn et al, 1997). Additionally, diabetes was also found to be related to an increased risk of urinary tract infection (Funfstuck et al, 2012) and urinary tract calculi (Chen et al, 2012), which was associated with various histologic types of bladder cancer, such as transitional cell carcinoma (Chow et al, 1997;Jankovic and Radosavljevic, 2007).…”

Section: Discussionmentioning

confidence: 99%

Obesity and Risk of Bladder Cancer: A Meta-analysis of Cohort Studies

Qin

Xu²,

Wang³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 99%

Obesity and Risk of Bladder Cancer: A Meta-analysis of Cohort Studies

Qin

Xu²,

Wang³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…The high urine glucose content and defective host immune factors predispose to infection. Hyperglycemia causes neutrophil dysfunction by increasing intracellular calcium levels and interfering with actin and, thus, diapedesis and phagocytosis [4].…”

Section: Introductionmentioning

confidence: 99%

Diabetes mellitus and Urinary Tract Infection: Spectrum of Uropathogens and their Antibiotic Sensitivity

Acharya

Bogati

Shrestha

et al. 2015

J. Manmohan Memorial Inst. Health. Sci.

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The incidence of urinary tract infections (UTIs) is common in both diabetic and non diabetic patients. Since the microorganisms causing UTI vary in their susceptibility to antimicrobials from place to place and time to time, hence constant screening of trends and susceptibility pattern of predominant organisms against antimicrobials is essential. The study aims to determine the spectrum of uropathogens and antibiotic sensitivity pattern in both diabetic and non diabetic patients with clinically suspected UTI .A prospective cross sectional study was conducted during period of February 2013 to July 2013 among 90 diabetic and 90 non diabetic patients attending Dhulikhel Hospital-Kathmandu University Hospital, Dhulikhel, Kavre (DH-KUH). All samples and isolates were investigated by standard laboratory procedures. A total of 55 (30.5%) samples showed significant growth. No significant difference among culture positivity rate was noted between diabetic and non diabetic patients (34.5% Vs 26.7%). Escherichia coli was the most frequent organism (64.5% in diabetic and 66.7% non diabetic) followed by Klebsiella sps (22.6% in diabetic and 12.5% in non diabetic). Gentamycin and nitrofurantoin were highly sensitive to E. coli isolated in diabetic patients among the tested antimicrobials followed by cotrimoxazole, norfloxacin and ciprofloxacin. Least sensitivity rate was observed with ampicillin and cephalexin. However, no difference was noted on the sensitivity pattern of the antimicrobials among E. coli isolated between diabetic and non diabetic patients.In this study high proportion of gram negative bacilli with predominant uropathogen being E. coli was noted. Irrespective of the status of diabetes, Staphylococcus sps and Pseudomonas sps were not isolated from UTI patients in our study. The isolation of organisms and their resistance pattern was almost similar between diabetic and non diabetic patients.Key words: Antibiotic Susceptibility Test, Diabetes mellitus, Urinary Tract Infection Introduction:

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“…Additionally, diabetes was also found to be related to an increased risk of urinary tract infection (Funfstuck et al, 2012) and urinary tract calculi (Chen et al, 2012), which was associated with various histologic types of bladder cancer, such as transitional cell carcinoma (Chow et al, 1997;Jankovic and Radosavljevic n.d.).…”

Section: Discussionmentioning

confidence: 99%