Urinary tract infection in the context of mini-invasive procedures after kidney transplantation

Abstract

INTRODUCTION: The use of antibiotic prophylaxis in invasive procedures is generally accepted and highly recommended. The question is the need to apply antibiotic prophylaxis even in the case of mini-invasive procedures in the post-transplantation period. The aim of the study was to determine the occurrence of infectious complications during mini-invasive procedures (pig-tail extraction, protocol biopsy) without the use of antibiotic (ATB) prophylaxis. The secondary aim was to identify risk factors for a positive urine culture fi nding at the time of mini-invasive procedures. MATERIAL: This is a prospective monocentric study in which patients after kidney transplantation at Transplantation centrum in Martin were included (n = 68). We investigated the incidence of positive urine fi ndings at the time of pig-tail extraction (6 weeks after transplantation) and at the time of protocol biopsy (3 months after transplantation) with comparison within the group with and without ATB prophylaxis. RESULTS: Patients in group without ATB prophylaxis had a signifi cantly higher tacrolimus value at the time of pig-tail extraction (p = 0.0274) and a signifi cantly higher dose of mycophenolic acid at the time of protocol biopsy (p = 0.0429). We did not confi rm signifi cant difference in occurrence of positive urine fi ndings at the time of pig-tail extraction or at the time of protocol biopsy. We completed a univariate logistic regression in order to identify a potential risk predictor for positive urine fi ndings at the time of pig-tail extraction and protocol biopsy. None of the monitored parameters, including ATB prophylaxis, was confi rmed as risk or protective factor. CONCLUSION: The use of antibiotic prophylaxis during mini-invasive procedures (pig-tail extraction, protocol biopsy) in the posttransplantation period had no effect on positive culture fi ndings at our department. Based on our analysis, we therefore do not use antibiotic prophylaxis in the case of these procedures at our centre

Effect of Different Induction Immunosuppression on the Incidence of Infectious Complications after Kidney Transplantation—Single Center Study

“…On the other hand, there was an increased incidence of acute cellular and humoral rejection in the basiliximab group from the sixth to the twelfth month after KT. In the past, the incidence of acute rejection was 10-30%; today, it is a maximum of 10% because of the implementation of protocol graft biopsy 3 months after kidney transplantation, when we can diagnose subclinical graft rejection [16].…”