Urinary trypsinogen-2 test strip for acute pancreatitis

Sequential Changes in Pancreatic Markers in Acute Pancreatitis

“…almost 14,000-fold. Furthermore, the concentrations of trypsinogen-2 correlated strongly with disease severity, thus confirming our earlier findings that trypsinogen-2 can be used to assess severity of the disease (10,28,30). It is likely that a dramatic increase in the urine concentrations of trypsinogen-2 is at least partially caused by a disturbed reabsorption associated with grossly increased excretion of protein fragments and peptides due to extensive tissue damage (28).…”

Use of the urinary trypsinogen-2 dip stick test in early diagnosis of pancreatitis after endoscopic retrograde cholangiopancreatography

“…It has been shown [3] that the use trysinogen-2 levels to diagnose pancreatitis lacks specificity because this enzyme can be released secondarily to inflammatory changes or malignancies in the pancreatic and biliary system. It is a consideration in the future to conduct a study using the urine dip stick test, to follow up pancreatic cancer patients after resection, and to diagnose recurrence.…”

Validity of the Urinary Trypsinogen-2 Test in the Diagnosis of Acute Pancreatitis

“…6 In healthy volunteers, small proportions of the 2 isoforms, trypsinogen 1 and trypsinogen 2, are freely filtered in the glomeruli and excreted in the urine. 7 During acute pancreatitis, a significant increase in the excretion of trypsinogen 2 has been observed, making the proenzyme a potential diagnostic marker for acute pancreatitis. 6Y8 Most of previous studies of trypsinogen measurements were conducted in a single or a small number of centers.…”