Urinary vanillylmandelic acid:creatinine ratio in dogs with pheochromocytoma

Arias, Elber Alberto Soler; Trigo, Roberto Hector; Miceli, Diego Daniel; Vidal, Patricia Noemi; Blanco, M.F. Hernandez; Castillo, V.

doi:10.1016/j.domaniend.2020.106559

Cited by 6 publications

(3 citation statements)

References 30 publications

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“…It is possible to measure the plasma and urinary concentration of catecholamines and their metabolites, such as metanephrine, normetanephrine and vanillylmandelic acid (SALESOV et al, 2015). A study by Soler et al (2021) revealed the vanillylmandelic acid to urinary creatinine ratio as a potential tool in the determination of pheochromocytoma in canine patients. Alternatively, serum inhibin measurement may be requested (BRÖMEL et al, 2013).…”

Section: Complementary Examsmentioning

confidence: 99%

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Pheochromocytoma in Dogs and Cats

Gouvêa

Pennacchi²,

Machado³

et al. 2022

Vet. Not.

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O feocromocitoma é uma neoplasia funcional produtora de catecolaminas, localizado na região medular das glândulas adrenais. Por apresentar sinais inespecíficos, escassez de ferramentas diagnósticas e ainda estar associado a doenças concomitantes, pode não ser considerado como afecção diferencial entre médicos veterinários. O feocromocitoma é uma neoplasia incomum e acomete animais com idade média a avançada, sendo o Poodle Miniatura, Pastor Alemão, Boxer, Golden Retriever e Pinscher as raças mais acometidas. As manifestações clínicas variam de acordo com os efeitos das catecolaminas e/ou comprometimento circulatório pela invasão local do tumor em estruturas adjacentes. Desta forma pode ser observado hipertensão arterial sistêmica e consequência em órgãos alvo como sistema nervoso central, rins e alterações oculares. O diagnóstico consiste na suspeita clínica, acompanhada de adrenomegalia nos exames de imagem. A mensuração de catecolaminas e seus metabolitos, como a metanefrina, normetanefrina e ácido vanilmandélico são ferramentas diagnósticas definitivas e como alternativa, a dosagem de inibina sérica pode ser feita na pesquisa de feocromocitoma. A adrenalectomia é a terapia de escolha, porém na inviabilidade deste, devem ser usados fármacos bloqueadores α e β adrenérgicos. O prognostico é variável entre reservado a ruim.

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Section: Complementary Examsmentioning

confidence: 99%

“…Pheochromocytoma is a functional neoplasm that produces catecholamines, located in the medullary region of the adrenal glands (ZINI et al, 2018). For many years it was diagnosed accidentally, since it has nonspeci c signs and limited diagnostic tools (GALAC; KORPERSHOEK, 2017;SOLER ARIAS et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Pheochromocytoma in Dogs and Cats

Gouvêa

Pennacchi²,

Machado³

et al. 2022

Vet. Not.

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“…It can be obtained as an undesirable byproduct of the condensation reaction of glyoxalic acid and guaiacol [ 15 ]. The presence of vanillymandelic acid, produced almost exclusively in the human liver, present in human urea indicates the presence of tumor cells such as PCC, paraganglioma or neuroblastoma [ 16 ]. Since the 1970s, VMA has also been used as a biomarker of metabolic disorders such as dopamine excretion disorders, as well as neurological disorders such as autism, post-traumatic stress disorder, Parkinson’s disease or depression [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Spectroscopic Characterization and Antioxidant Properties of Mandelic Acid and Its Derivatives in a Theoretical and Experimental Approach

et al. 2022

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The following article discusses the antioxidant properties of mandelic acid and its hydroxy and methoxy derivatives. The antioxidant capacity of these compounds is determined by DPPH, FRAP, CUPRAC and ABTS. The mechanisms underlying the antioxidant properties are described by BDE, IP, PDE, ETE and PA calculation method values and referenced to experimental data. Thermochemistry, HOMO/LUMO energies, dipole moments, charge distribution, IR, RAMAN, NMR frequencies, binding lengths and angles were calculated using the B3LYP method and the 6-311++G(d,p) basis set. The structure of mandelic acid and its derivatives was determined experimentally using IR and RAMAN spectroscopy.

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Detection of catecholamine metabolites in urine based on ultra‐high‐performance liquid chromatography–tandem mass spectrometry

Zhang

Wang

et al. 2021

Biomedical Chromatography

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The excretion of neurotransmitter metabolites in normal individuals is of great significance for health monitoring. A rapid quantitative method was developed with ultra‐performance liquid chromatography–tandem mass spectrometry. The method was further applied to determine catecholamine metabolites vanilymandelic acid (VMA), methoxy hydroxyphenyl glycol (MHPG), dihydroxy‐phenyl acetic acid (DOPAC), and homovanillic acid (HVA) in the urine. The urine was collected from six healthy volunteers (20–22 years old) for 10 consecutive days. It was precolumn derivatized with dansyl chloride. Subsequently, the sample was analyzed using triple quadrupole mass spectrometry with an electrospray ion in positive and multireaction monitoring modes. The method was sensitive and repeatable with the recoveries 92.7–104.30%, limits of detection (LODs) 0.01–0.05 μg/mL, and coefficients no less than 0.9938. The excretion content of four target compounds in random urine samples was 0.20 ± 0.086 μg/mL (MHPG), 1.27 ± 1.24 μg/mL (VMA), 3.29 ± 1.36 μg/mL (HVA), and 1.13 ± 1.07 μg/mL (DOPAC). In the urine, the content of VMA, the metabolite of norepinephrine and adrenaline, was more than MHPG, and the content of HVA, the metabolite of dopamine, was more than DOPAC. This paper detected the levels of catecholamine metabolites and summarized the characteristics of excretion using random urine samples, which could provide valuable information for clinical practice.

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Urinary vanillylmandelic acid:creatinine ratio in dogs with pheochromocytoma

Cited by 6 publications

References 30 publications

Pheochromocytoma in Dogs and Cats

Pheochromocytoma in Dogs and Cats

Spectroscopic Characterization and Antioxidant Properties of Mandelic Acid and Its Derivatives in a Theoretical and Experimental Approach

Detection of catecholamine metabolites in urine based on ultra‐high‐performance liquid chromatography–tandem mass spectrometry

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