Urine acute kidney injury biomarkers in extremely low gestational age neonates: a nested case control study of 21 candidate urine biomarkers

Askenazi, David; Halloran, Brian; Heagerty, Patrick J.; Schmicker, Robert H.; Juul, Sandra E.; Hingorani, Sangeeta; Goldstein, Stuart L.

doi:10.1007/s00467-022-05688-x

Cited by 6 publications

(4 citation statements)

References 23 publications

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“…One possible explanation is that VEGF levels may be related to the course of AKI 40 . Previous studies have also shown that in nAKI, VEGF in urine is lower on day 1 and higher on day 5 of AKI 41 .…”

Section: Vegfmentioning

confidence: 76%

“…39 Previous studies have also shown that in nAKI, VEGF in urine is lower on day 1 and higher on day 5 of AKI. 40 One possible mechanism by which maternal antibiotic exposure affects offspring behavior in rats is that VEGF and other metabolites cause gut dysbiosis. 41 This suggests that VEGF is closely related to gut microbiota, but this relationship may depend on VEGF subclasses.…”

Section: Vascular Endothelial Growth Factormentioning

confidence: 99%

“…75 In addition to its anti-inflammatory properties, ghrelin antagonized renal tubular epithelial cell apoptosis and improved renal vascular endothelial function to mitigate ischemia-reperfusion-induced AKI in mice. 76,77 Clinical studies have shown higher urinary levels of ghrelin in very low gestational age neonates with early severe AKI than in those without AKI, 40 suggesting the potential of ghrelin as a biomarker for nAKI.…”

Section: Ghrelinmentioning

confidence: 99%

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Gut Microbiota and Neonatal Acute Kidney Injury

Yang,

He,

Dong

2024

Am J Perinatol

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Neonatal acute kidney injury has a complex pathogenesis and the gut microbiota is receiving increasing attention. Gut-kidney axis establishes a bidirectional link between gut microbiota and acute kidney injury. Promoting the study of gut microbiota and neonatal acute kidney injury will contribute to early detection and treatment of this disease. A series of promising biomarkers have emerged in recent years to predict neonatal acute kidney injury earlier than serum creatinine and urine output. However, comprehensive reports on these biomarkers are relatively scarce. In addition, the gut microbiota and biomarkers associated with neonatal acute kidney injury deserve further exploration. Herein, this review summarizes the relationship between gut microbiota and neonatal acute kidney injury biomarkers to deepen our understanding of the role of the gut-kidney axis in neonatal acute kidney injury and provide potential treatment options for neonatal acute kidney injury.

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Section: Vegfmentioning

confidence: 76%

Section: Vascular Endothelial Growth Factormentioning

confidence: 99%

Section: Ghrelinmentioning

confidence: 99%

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Gut Microbiota and Neonatal Acute Kidney Injury

Yang,

He,

Dong

2024

Am J Perinatol

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“…It was associated with plasma vascular endothelial growth factor-A and CX3CL1 levels (Supplemental Table 10), which were reported to be elevated in AKI. 59,60 Its genomic location was in the enhancer state, colocalized with epigenetic markers such as H3K27ac and Assay for Transposase-Accessible Chromatin peaks in several cell types including renal cortical epithelial cells, CD14-positive monocytes, T helper 2 cells, and kidney myeloid cells (Supplemental Figure 7), suggesting that PLEKHA5 might be functionally relevant for inflammation.…”

Section: Novel Association With Plekha5mentioning

confidence: 99%

Genome-Wide Association Study in Acute Tubulointerstitial Nephritis

Zhou

Xie

et al. 2023

JASN

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Background Acute tubulointerstitial nephritis (ATIN) is a rare immune-related disease, accounting for approximately 10% of patients with unexplained AKI. Previous elucidation of the relationship between genetic factors that contribute to its pathogenesis was hampered because of small sample sizes and candidate gene design.Methods We undertook the first two-stage genome-wide association study and meta-analysis involving 544 kidney biopsy-defined patients with ATIN and 2346 controls of Chinese ancestry. We conducted statistical fine-mapping analysis, provided functional annotations of significant variants, estimated single nucleotide polymorphism (SNP)-based heritability, and checked genotype and subphenotype correlations.Results Two genome-wide significant loci, rs35087390 of HLA-DQA1 (P53.01310 239 ) on 6p21.32 and rs2417771 of PLEKHA5 on 12p12.3 (P52.14310 28 ), emerged from the analysis. HLA imputation using two reference panels suggested that HLA-DRB1*14 mainly drives the HLA risk association. HLA-DRB1 residue 60 belonging to pocket P10 was the key amino acid position. The SNP-based heritability estimates with and without the HLA locus were 20.43% and 10.35%, respectively. Different clinical subphenotypes (drug-related or tubulointerstitial nephritis and uveitis syndrome) seemed to share the same risk alleles. However, the HLA risk genotype was associated with disease severity and response rate to immunosuppressive therapy. ConclusionsWe identified two candidate genome regions associated with susceptibility to ATIN. The findings suggest that a genetically conferred risk of immune dysregulation is involved in the pathogenesis of ATIN.

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Gut microbiota and neonatal acute kidney injury biomarkers

Yang

Liu

et al. 2023

Pediatr Nephrol

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Urine acute kidney injury biomarkers in extremely low gestational age neonates: a nested case control study of 21 candidate urine biomarkers

Cited by 6 publications

References 23 publications

Gut Microbiota and Neonatal Acute Kidney Injury

Gut Microbiota and Neonatal Acute Kidney Injury

Genome-Wide Association Study in Acute Tubulointerstitial Nephritis

Gut microbiota and neonatal acute kidney injury biomarkers

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