Urine albumin-to-creatinine ratio on admission predicts early rehospitalization in patients with acute decompensated heart failure

Matsumoto, Yuki; Orihara, Yoshiyuki; Asakura, Masanori; Min, Kyung‐Duk; Okuhara, Yoshitaka; Azuma, Kohei; Nishimura, Koichi; Sunayama, Isamu; Kashiwase, Kazunori; Naito, Yoshiro; Goda, Akiko; Ishihara, Masaharu

doi:10.1007/s00380-022-02025-y

Cited by 6 publications

(13 citation statements)

References 41 publications

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“…The study of Alataş et al 4 suggests that microalbuminuria is a predictor of in-hospital mortality, especially in those with reduced ejection fraction. Although the precise relationship between UACR, EF and other markers such as cardiac natriuretic peptides may differ depending on the characteristics of patients and outcomes of interest, this study 4 and other recent ones 7,8 open a new interesting area of research and individualized clinical approach.…”

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confidence: 84%

“…However, the predictive value of UACR in subgroups categorized according to EF was not examined. 8 In conclusion, microalbuminuria emerges as a novel promising marker in patients with acute heart failure. The study of Alataş et al 4 suggests that microalbuminuria is a predictor of in-hospital mortality, especially in those with reduced ejection fraction.…”

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confidence: 97%

“…In contrast, Wang et al 7 examined only patients with decompensated HF, younger age (median 57 years), higher eGFR (mean about 90 ml/min) and assessed the outcome within the median period of almost 3 years. In addition, UACR was reported in the study of Alataş et al 4 whereas only absolute urinary creatinine concentration was measured by Wang et al 7 Very recently, Matsumoto et al 8 demonstrated that the risk of early (within 1 year) rehospitalization was higher in patients with ADHF and micro-or macroalbuminuria than in those with normoalbuminuria. In multivariate analysis, UACR and BNP were the independent predictors of rehospitalization.…”

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confidence: 99%

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Microalbuminúria e o Risco de Mortalidade em Pacientes com Insuficiência Cardíaca Aguda

Bełtowski¹

2022

Arquivos Brasileiros De Cardiologia

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confidence: 84%

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confidence: 97%

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confidence: 99%

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Microalbuminúria e o Risco de Mortalidade em Pacientes com Insuficiência Cardíaca Aguda

Bełtowski¹

2022

Arquivos Brasileiros De Cardiologia

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“…In 1 study, the level of UACR on admission for HF was correlated with the risk of subsequent rehospitalization for HF. 34 A meta‐analysis of 11 studies of patients with HF revealed a statistically significant increased risk of all‐cause mortality with microalbuminuria and macroalbuminuria. 35 …”

Section: Association Of Albuminuria With Cardiovascular Diseasementioning

confidence: 99%

“…First, we discuss the physiology and pathophysiology of urinary albumin excretion, followed by the association of albuminuria with CVD (Table 1 ). 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 Last, we review the medications now available for lowering levels of albuminuria, which in turn are associated with a reduction in CVD risk and cardiorenal events.…”

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confidence: 99%

Albuminuria: An Underappreciated Risk Factor for Cardiovascular Disease

Barzilay,

Farag,

Durthaler

2024

JAHA

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Albuminuria, an established biomarker of the progression of chronic kidney disease, is also recognized as a biomarker for the risk of cardiovascular disease. Elevated urinary albumin excretion indicates kidney damage and systemic vascular disease, including myocardial capillary disease and arterial stiffness. Albuminuria is associated with an increased risk of coronary artery disease, stroke, heart failure, arrhythmias, and microvascular disease. There are now several therapeutic agents that can lead to albuminuria lowering and a reduction in cardiovascular risk. However, screening for albuminuria is still low. Considering the importance of multidisciplinary management of patients with cardiovascular disease, it is crucial that health care professionals managing such patients are aware of the benefits of albuminuria surveillance and management.

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Congestion as a crucial factor determining albuminuria in patients with cardiorenal disease

Llàcer,

Cobo Marcos,

de la Espriella

et al. 2024

Clinical Kidney Journal

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Background Albuminuria could potentially emerge as a novel marker of congestion in acute heart failure. However, the current evidence linking albuminuria and congestion in patients with chronic heart failure (CHF) remains somewhat scarce. This study aimed to evaluate 1) the prevalence of albuminuria in a cohort of patients with CHF, 2) identify the independent factors associated with albuminuria, and 3) to analyze the correlation with different congestion parameters. Methods and Results This is a sub-analysis of the Spanish Cardiorenal Registry, in we which enrolled 864 outpatients with heart failure and a value of urinary albumin-to-creatinine ratio (UACR) at the first visit. The median age was 74 years, 549 (63.5%) were male, and 438 (50.7%) had a reduced left ventricular ejection fraction. A total of 350 patients (40.5%) had albuminuria. Among these patients, 386 (33.1%) had a UACR between 30 and 300 mg/g, while 64 (7.4%) had a UACR greater than 300 mg/g. In order of importance the independent variables associated with higher UACR were in Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), (R2: 57.6%), systolic blood pressure (SBP) (R2: 21.1%), previous furosemide equivalent dose (R2: 7.5%), antigen carbohydrate 125 (CA125) (R2: 6.1%), diabetes mellitus (R2: 5.6%) and edemas (R2: 1.9%). The combined influence of edema, elevated CA125 levels, and the furosemide equivalent dose accounted for 15.5% of the model's variability. Conclusions In patients with chronic stable heart failure, the prevalence of albuminuria is high. The risk factors of albuminuria in this population are chronic kidney disease and hypertension. Congestion parameters are also associated with increased albuminuria.

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Urine albumin-to-creatinine ratio on admission predicts early rehospitalization in patients with acute decompensated heart failure

Cited by 6 publications

References 41 publications

Microalbuminúria e o Risco de Mortalidade em Pacientes com Insuficiência Cardíaca Aguda

Microalbuminúria e o Risco de Mortalidade em Pacientes com Insuficiência Cardíaca Aguda

Albuminuria: An Underappreciated Risk Factor for Cardiovascular Disease

Congestion as a crucial factor determining albuminuria in patients with cardiorenal disease

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