Urine concentration and dilution in the rat: Contribution of papillary structures during high rates of urine flow

Martínez‐Maldonado, Manuel; Opava-Stitzer, Susan C.

doi:10.1038/ki.1978.29

Cited by 23 publications

(16 citation statements)

References 23 publications

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“…The reasons for the apparent discrepancy between the present results and those reported by others (Lief et nl., 1969;Martinez-Maldonado and Opava-Stitzer, 1978) are not clear. GFR was not significantly impaired in papillectomized animals in our hands or in those of Lief ct al.…”

Section: Discussionmentioning

confidence: 99%

“…Two previous investigations (Lief etal, 1969;Martinez-Maldonado and Opava-Stitzer, 1978) have examined in detail the effects of papillectomy on concentrating capacity by determining PH^^O at high rates of solute delivery to the distal nephron, achieved by the intravenous infusion of hypertonic saline. Both reports described a diminished Um.•,^.…”

Section: Discussionmentioning

confidence: 99%

“…A loss of the structural integrity of any of these components can result in impairment of renal eoncentrating capacity, as seen, for example, after surgical resection of the renal papilla (Lanari et al, 1967;Lief et al, 1969;Martinez-Maldonado and Opava-Stitzer, 1978;Marshall et al, 1963;Sokabe and Grollman, 1963;Wilson, 1972) or after the production of renal papillary necrosis (Arruda ct al, 1979) even when only the thin limbs of Henle's loops are necrotic and the collecting ducts are preserved (Gobe and Axelsen, 1982). Resection of the renal papilla could result in the failure to excrete a concentrated urine because of loss of the terminal collecting ducts, loss of the thin limbs of juxtamedullary nephrons or loss of the function of the ascending thick limbs of nephrons whose thin limbs had been transected.…”

Section: Discussionmentioning

confidence: 99%

“…Studies in the papillectomized rat have been reported as showing that free water reabsorption is normal at high rates of urine flow (Lief et al, 1969;Martinez-Maldonado and Opava-Stitzer, 1978) provided that the outer medulla, containing the ascending thick limbs of Henle's loops, is not damaged (Martinez-Maldonado and Opava-Stitzer, 1978). It seemed paradoxical to us that surgical removal of the terminal collecting ducts, the thin limbs of Henle's loops and the blood vessels of the distal part of the papilla should have no effect on free water reabsorption, while necrosis of these same structures should impair this parameter of concentrating capacity (Arruda et ai.…”

Section: Introductionmentioning

confidence: 99%

“…Surgical removal of the renal papilla results in an impairment of urinary concentrating capacity in the rat (Lief, Sullivan and Goldberg, 1969;Martinez-Maldonado and Opava-Stitzer, 1978;Sokabc and Grollman, 1963;Wilson, 1972), the hamster (Marshall, Miller and Farah, 1963) and the dog (Lanari et ai, 1967). Studies in the papillectomized rat have been reported as showing that free water reabsorption is normal at high rates of urine flow (Lief et al, 1969;Martinez-Maldonado and Opava-Stitzer, 1978) provided that the outer medulla, containing the ascending thick limbs of Henle's loops, is not damaged (Martinez-Maldonado and Opava-Stitzer, 1978).…”

Section: Introductionmentioning

confidence: 99%

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Impaired Renal Concentrating Capacity in the Rat After Surgical Resection of the Papilla

Gobé

Axelsen

1984

Aust J Exp Biol Med

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Summary.Renal cortical and medullary function was examined In rals 4 weeks after surgical resection of the distal portion of the renal papilla had been performed. Glomerular filtration rate (GFR), obtained during fhe determination of free water reabsorption (TcH-jO) at high rates of urine flow, did not differ significantly among controls (1-62 it 0 19 ml/min, n -5), sham operated animals (145 ± 0-16, n = 4) and papillectomized animals (1 49 ± 0-21, n = 7). Maximum urinary osmoiality (tj,,,^,) was 2216 it 293 mOsm/kg in controls, and was significantly reduced in sham operated (1737 it 261, P <005) and papillectomized animals (889 ± 143, P <0.0001). Tf^HoO was normal in sham operated animals at high rates of osmolar clearance (Co.m), but was significantly impaired after resection of the retial papilla. These results suggest that removal of the terminal collecting ducts and interruption of nephrons with long loops extending into the papilla impair the mEUimal generation of solute free water.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Impaired Renal Concentrating Capacity in the Rat After Surgical Resection of the Papilla

Gobé

Axelsen

1984

Aust J Exp Biol Med

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Morphological study of the desert heteromyid kidney with emphasis on the genus perognathus

et al. 1979

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The renal morphology of three species of desert dwelling Perognathus rodents were compared to Dipodomys and two species of sympatric cricetid rodents. Perognathus has a highly adapted unipolar kidney capable of urine concentration up to 7,500 mOsm/KgH2O. Two major modifications were observed in these kidneys. (1) There is elongation of both the inner and outer medulla. When the thickness of the regions in P. penicillatus are factored by kidney weight it is found that the outer medulla is 3.8 and the inner medulla is 2.2 times greater in length than the extensively studied Dipodomys merriami. (2) There is great variance in glomerular size with approximately 20% of the glomeruli being very large and located in the juxta medullary region. These glomeruli are 1.5--1.6 times greater in diameter than the more numerous superficial glomeruli. These structural modifications are quantitated and the functional implications are discussed particularly in relation to urine concentrating ability in these desert inhabitants.

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The effects of chronic papillary necrosis on acid excretion

et al. 1982

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Complete papillary necrosis in rats can be induced within 1 month following a single injection of 2-bromoethylamine hydrobromide (BEA) (50 mg, i.v.). Utilizing a combination of clearance and balance techniques the effects of complete absence of the papilla was examined as regards urinary acidification, whole kidney glomerular filtration rate (GFR), single nephron GFR, and morphology. Whole kidney GFR was not different from control, however, the percent filtering juxtamedullary nephrons was markedly diminished (87.2 +/- 2.1 vs. 31.5 +/- 3.6% filtering, control vs. BEA, respectively, P less than 0.001) and significantly reduced in the superficial nephrons (80.6 +/- 3.6 vs. 62.2 +/- 6.1% filtering, control vs. BEA, respectively, P less than 0.05). There was a significant decrease in juxtamedullary single nephron GFR and an increase in the superficial single nephron GFR as assessed by the quantitative Hanssen's technique in the animals with chronic papillary necrosis. Complete papillary necrosis was associated with normal arterial bicarbonate concentration, pH, and plasma electrolyte concentrations. At the same degree of acidemia (induced by NH4Cl administration) minimal urinary pH, ammonium excretion, and titratable acid excretion were not different than seen in age matched controls. The response to Na2SO4 infusion and phosphate infusion was the same in both groups of animals. The urine-blood (U-B)pCO2, and index of urinary acidification, was identical in BEA and control animals. Scanning electron microscopy showed scarring of the juxtamedullary glomeruli one month after BEA. The papilla was sloughed and lying free in the renal pelvis in every experimental animal. These data demonstrate that complete papillary necrosis is not associated with acidosis nor a defect in urinary acidification.

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Urine concentration and dilution in the rat: Contribution of papillary structures during high rates of urine flow

Cited by 23 publications

References 23 publications

Impaired Renal Concentrating Capacity in the Rat After Surgical Resection of the Papilla

Impaired Renal Concentrating Capacity in the Rat After Surgical Resection of the Papilla

Morphological study of the desert heteromyid kidney with emphasis on the genus perognathus

The effects of chronic papillary necrosis on acid excretion

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