Urine Concentrations of Cysteinyl Leukotrienes in Children With Obstructive Sleep-Disordered Breathing

Increased urinary leukotriene E4 excretion in obstructive sleep apnea: Effects of obesity and hypoxia

“…3 In children with OSA, LTE 4 was associated with an increased BMI z score in the subgroup of children with moderateto-severe OSA. 16 The current study demonstrated that LTE 4 urinary concentrations increased as a function of BMI in patients with OSA. Previous studies have identified obesity as an inflammatory state, 6 and the LT pathway is expressed in macrophages infiltrating adipose tissue in mouse models of atherosclerosis and obesity.…”

“…These studies have been performed in children and demonstrated (1) increased concentrations of cysLTs in exhaled breath condensate 15 and urine, 16 (2) an enhanced expression of cysLT type 1 and 2 receptors in tonsillar T lymphocytes of children with OSA, 17 and (3) an increase proliferation of adenotonsillar cells in response to LTD 4 that is reversed by cysLT 1 receptor antagonist. 18 No data are available in the completely different context of OSA in middle-age adults.…”

Effects of obstructive sleep apnea severity on serum lipid levels in Greek children with snoring

“…A child was considered obese when the BMI z score exceeded 1.645 [18]. Overnight polysomnography recordings included: electroencephalography (C3/A2, C4/A1, O1/A2); right and left oculogram; submental and tibial electromyogram; body position; electrocardiogram; thoracic and abdominal wall movements; oronasal airflow; and oximetry [19]. Obstructive apnea was the absence of airflow for at least two breaths in duration in the presence of chest and/or abdominal wall motion [20].…”

Increased cysteinyl leukotriene concentration and receptor expression in tonsillar tissues of Chinese children with sleep-disordered breathing

“…Of note, systemic inflammation was also widely reported to contribute to the pathophysiological mechanisms and even the emergence of cardiovascular and neurobehavioral complication of SDB [25,26]. Rises in urinary CysLTs have been reported to indicate SDB severity [27,28]. Therefore, the current findings may serve as supplementary evidence that the analysis of both circulating and airway CysLT levels could be applied as a reliable screening method in assessing severity of the disease.…”