2020
DOI: 10.1093/ndt/gfaa169
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Urine interleukin-9 and tumor necrosis factor-α for prognosis of human acute interstitial nephritis

Abstract: Graphical Abstract Background We previously demonstrated that urine interleukin (IL)-9 and tumor necrosis factor (TNF)-α can distinguish acute interstitial nephritis (AIN) from other causes of acute kidney injury. Here we evaluated the role of these biomarkers to prognosticate kidney function in patients with AIN. Methods In a cohort of participants with biopsy-proven, adjudicated AIN, we tes… Show more

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Cited by 35 publications
(26 citation statements)
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“…Figure 2. Examples of potential use cases for kidney tubule injury and dysfunction biomarkers in clinical practice, for the purposes of prognosis, 20,27,37 treatment selection, 36 monitoring for treatment effectiveness, 41,42 monitoring for medication safety, 29,43 and distinguishing injury from hemodynamic causes of declining eGFR. [33][34][35] Abbreviations: CKD, chronic kidney disease; CVD, cardiovascular disease; eGFR, estimated glomerular filtration rate; HIV, human immunodeficiency virus.…”
Section: Monitoring For Medicaɵon Safetymentioning
confidence: 99%
See 1 more Smart Citation
“…Figure 2. Examples of potential use cases for kidney tubule injury and dysfunction biomarkers in clinical practice, for the purposes of prognosis, 20,27,37 treatment selection, 36 monitoring for treatment effectiveness, 41,42 monitoring for medication safety, 29,43 and distinguishing injury from hemodynamic causes of declining eGFR. [33][34][35] Abbreviations: CKD, chronic kidney disease; CVD, cardiovascular disease; eGFR, estimated glomerular filtration rate; HIV, human immunodeficiency virus.…”
Section: Monitoring For Medicaɵon Safetymentioning
confidence: 99%
“…Among the AIN patients who received corticosteroids, there were larger improvements in eGFR over a 6-month follow-up period in the subgroup of patients with higher urine IL-9 levels at baseline, whereas the subgroup with lower IL-9 levels had less interstitial infiltration and did not have improvements in eGFR with corticosteroid treatment over the subsequent 6 months. 36 In summary, the etiologies for reductions in eGFR are heterogeneous, and clinicians do not currently have tools to differentiate their causes in clinical practice. Given their concerns for intrinsic kidney injury, clinicians often feel compelled to interrupt beneficial medications, such as antihypertensive or antiretroviral medications, and then rely upon observation time to determine whether the kidney "recovers" based upon the eGFR response.…”
Section: Tubule Injury and Dysfunction Biomarkers For Monitoring Ther...mentioning
confidence: 99%
“…As an inflammatory disease, unlike most cases of DATIN, patients with AI-ATIN showed higher chances of relapse. Although clinical evidence for immunosuppressive treatment therapy is not solid for DATIN up to now, AI-ATIN usually needed more enhanced and longer courses of immunosuppressive treatment [ 5 , 8–11 , 13 , 15 , 16 , 30 ]. However, in our previous study, 46.2% of AI-ATIN patients were originally presented and treated as DATIN or for unclarified causes at renal biopsy [ 13 ].…”
Section: Discussionmentioning
confidence: 99%
“…These glucocorticoid actions are nicely illustrated in a Considering that DI-AIN is being observed with increasing frequency in elderly subjects 3 whose frailty makes it difficult or contraindicates the performance of a kidney biopsy, the search for noninvasive diagnostic biomarkers is of crucial importance. In this regard, recent investigations suggest that the levels of urine tumor necrosis factor-α and interleukin-9 can discriminate AIN from acute tubular injury and other kidney lesions 4 . Donati and Krishnan review the studies that support the efficacy of glucocorticoids in the recovery of kidney function in DI-AIN.…”
Section: Should Corticosteroids Be Employed To Treat Biopsy-proven Drug-induced Acute Interstitial Nephritis? Commentarymentioning
confidence: 99%