Urine: Waste product or biologically active tissue?

,

doi:10.1002/nau.23414

Cited by 10 publications

(12 citation statements)

References 85 publications

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“…This bioregulatory definition is not intended to represent an exhaustive or comprehensive list of all the biologic functions of the bladder, but rather to highlight the importance of bioregulatory function and acknowledge the role of the urothelium and microbiome in BH. 26 With the introduction of new research terminology, feedback from users will be critical. Homma noted that as LUTS terminology was used, confusion developed among researchers and clinicians when the terms were used as both symptoms and cystometric terms.…”

Section: Discussionmentioning

confidence: 99%

“…Finally, the novel concept of a bladder "bioregulatory" function was acknowledged, recognizing that the bladder lining and urine composition may play a role in BH and dysfunction. 26 Definitions were proposed for a "Biosis barrier" describing the role of the bladder microbiome in preventing infection, a "chemical or physical barrier" describing the role of the urothelium in prevention of absorption of chemicals, and a "neoplastic barrier" describing the regulated turnover of cells to maintain health and prevent malignancy. Unlike the storage and emptying functions, which can be assessed subjectively, the bioregulatory functions require objective assessment.…”

Section: Methodsmentioning

confidence: 99%

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Terminology for bladder health research in women and girls: Prevention of Lower Urinary Tract Symptoms transdisciplinary consortium definitions

Lowder

Bavendam

Berry

et al. 2019

Neurourology and Urodynamics

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Aim To report research terminology and definitions for describing healthy bladder function among women and girls. Methods The Prevention of Lower Urinary tract Symptoms (PLUS) Consortium developed research terminology and definitions for elements of healthy bladder function based on existing understanding of storage and emptying functions of the bladder and accepted definitions of lower urinary tract symptoms (LUTS). The novel concept of a bladder “bioregulatory” function was also proposed. Elements of bladder function corresponding to bladder health (BH) and LUTS were developed and refined using an iterative process. A comprehensive reference table structured by bladder function (Storage, Emptying, and Bioregulatory) and elements of each function was created to document proposed research terminology and definitions. Results The BH research definitions for each bladder function are: (1) Storage: the ability to hold urine for a reasonable duration of time and sense bladder fullness without fear of or concern about urgency, discomfort or leakage; (2) Emptying: the ability to empty the bladder completely in a timely, efficient, effortless, comfortable manner; and (3) Bioregulatory: the bladder barrier protects the individual/host from pathogens, chemicals, and malignancy. Research definitions for seven Storage, seven Emptying, and three Bioregulatory elements of function are presented. Novel LUTS research definitions were developed when gaps in existing definitions were identified or nonclinical language was desired. Conclusions PLUS BH definitions reflect a transdisciplinary approach to standardizing research definitions for elements of bladder function from a perspective of health rather than dysfunction and provide a framework for studying BH in clinical practice, public health promotion, and LUTS prevention.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Terminology for bladder health research in women and girls: Prevention of Lower Urinary Tract Symptoms transdisciplinary consortium definitions

Lowder

Bavendam

Berry

et al. 2019

Neurourology and Urodynamics

View full text Add to dashboard Cite

show abstract

“…In contrary, urine and stool are excreted from the body, yet they cannot be regarded as simple “waste products” as it was done earlier. Urine contains a lot of water-soluble and metabolic by-products which can be used for diagnostic or prognostic purposes [ 21 , 22 ]. In human feces small compounds and metabolites can be found in the dry mass that can be used for metabolomics studies.…”

Section: Discussionmentioning

confidence: 99%

Comparing Metabolomics Profiles in Various Types of Liquid Biopsies among Screening Participants with and without Advanced Colorectal Neoplasms

et al. 2021

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Analysis of metabolomics has been suggested as a promising approach for early detection of colorectal cancer and advanced adenomas. We investigated and compared the metabolomics profile in blood, stool, and urine samples of screening colonoscopy participants and aimed to evaluate differences in metabolite concentrations between people with advanced colorectal neoplasms and those without neoplasms. Various types of bio-samples (plasma, feces, and urine) from 400 participants of screening colonoscopy were investigated using the MxP® Quant 500 kit (Biocrates, Innsbruck, Austria). We detected a broad range of metabolites in blood, stool, and urine samples (504, 331, and 131, respectively). Significant correlations were found between concentrations in blood and stool, blood and urine, and stool and urine for 93, 154, and 102 metabolites, of which 68 (73%), 126 (82%), and 39 (38%) were positive correlations. We found significant differences between participants with and without advanced colorectal neoplasms for concentrations of 123, 49, and 28 metabolites in blood, stool and urine samples, respectively. We detected mostly positive correlations between metabolite concentrations in blood samples and urine or stool samples, and mostly negative correlations between urine and stool samples. Differences between subjects with and without advanced colorectal neoplasms were found for metabolite concentrations in each of the three bio-fluids.

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“…More studies are needed to advance our knowledge of the impact of the bladder lymphatics in metastatic bladder cancers and their exosomes, and of the identity and nature of tumor exosome contents. Similar questions could be also asked to lower urinary tract symptoms (LUTS) including urinary incontinence, overactive bladder, interstitial cystitis/bladder pain syndrome, and urinary tract infections et al However, not much efforts have been invested to understand the casual connection between bladder lymphatic system and LUTS [ 29 ]. Thus, our collaborative research team has started working on the biological roles of urinary exosomes in LUTS and its underlying mechanism in bladder pathogenesis.…”

mentioning

confidence: 99%

Exosomes as a Communication Tool Between the Lymphatic System and Bladder Cancer

Park

Hong

et al. 2018

Int Neurourol J

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Urine: Waste product or biologically active tissue?

Abstract: Moving forward, there are several questions that need further understanding and pursuit. There were suggestions to consider actively using various animal models and their biological specimens to elaborate on basic mechanistic information regarding human bladder dysfunction.

Cited by 10 publications

References 85 publications

Terminology for bladder health research in women and girls: Prevention of Lower Urinary Tract Symptoms transdisciplinary consortium definitions

Terminology for bladder health research in women and girls: Prevention of Lower Urinary Tract Symptoms transdisciplinary consortium definitions

Comparing Metabolomics Profiles in Various Types of Liquid Biopsies among Screening Participants with and without Advanced Colorectal Neoplasms

Exosomes as a Communication Tool Between the Lymphatic System and Bladder Cancer

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