Uro‐genital Infection of the Male in Relation to Ankylosing Spondylitis and Rheumatoid Arthritis

Julkunen, Heljo; Pietilä, K; Elo, Jaakko

doi:10.1111/j.0954-6820.1966.tb05462.x

Cited by 6 publications

(1 citation statement)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Based on the typical disease characteristics, a Finnish rheumatologist Dr Heljo Julkunen did pioneering work in the 1960s, studying and pointing out the eventual association between chronic prostatitis [5] and salpingo-oophoritis [6], now often referred to as pelvic inflammatory disease or PID, with rheumatoid spondylitis as ankylosing spondylitis was then called. This approach was based on the typical disease topology (axial involvement) and kinetics (ascending nature) (Fig.…”

Section: Chronic Prostatitis and Pelvic Inflammatory Disease In Ankylmentioning

confidence: 99%

Microbial antigens mediate HLA-B27 diseases via TLRs

Pöllänen

Sillat

Pajarinen

et al. 2009

Journal of Autoimmunity

View full text Add to dashboard Cite

Section: Chronic Prostatitis and Pelvic Inflammatory Disease In Ankylmentioning

confidence: 99%

Microbial antigens mediate HLA-B27 diseases via TLRs

Pöllänen

Sillat

Pajarinen

et al. 2009

Journal of Autoimmunity

View full text Add to dashboard Cite

Autoimmune epididymoorchitis is essential to the pathogenesis of male‐specific spondylarthritis in HLA–B27–transgenic rats

Taurog

Rival

Duivenvoorde

et al. 2012

Arthritis & Rheumatism

View full text Add to dashboard Cite

Objective Male rats transgenic for HLA-B27 and human-β2-microglobulin (Hu-β2m) spontaneously develop epididymo-orchitis preceding spondyloarthritis. In the specific B27/Hu-β2m transgenic cross (21-3x382-2)F1, only the males develop spondyloarthritis, and neither sex develops gut inflammation. We asked whether epididymo-orchitis and spondyloarthritis in the (21-3x382-2)F1 males are causally related, and we characterized the epididymo-orchitis. Methods B27/Hu-β2m (21-3x382-2)F1 transgenic males underwent bilateral, unilateral, or sham epididymo-orchiectomy between ages 36 and 125 d. Castrated rats were given testosterone replacement. Alternatively, the 21-3 and 283-2 transgene loci were crossed with a transgene inducing aspermatogenesis. Rats were observed for epididymo-orchitis, arthritis, and spondylitis. Results In unmanipulated transgenic rats, inflammation was first evident in the ductuli efferentes (DE, ducts linking rete testis to epididymis) as early as age 30 d. The inflammation was initially neutrophilic, and later became granulomatous. Serum anti-sperm and anti-testis cell antibodies appeared after age 70 d. Cells infiltrating the testes were predominantly CD4+ T cells and CD68+ or CD163+ macrophages. Quantitative PCR of DE, epididymis, and testis showed elevations of IFNγ, IL-10, andIL-17A. IL-12A, IL-22, IL-23A, and IL-23R were also examined in DE and found elevated. Remarkably, castration before 91 d of age completely prevented subsequent arthritis and spondylitis, as did transgene-induced azospermia. Conclusion In the (21-3x283-2)F1 HLA-B27/Hu-β2m transgenic rats, autoimmune epididymo-orchitis develops spontaneously at 30 d, the age when antigen-positive meiotic germ cells first exit the testis. Persistent testicular inflammation and/or antigenic stimulation are essential prerequisites to subsequent spondyloarthritis. Dysregulated innate immunity at immune privileged sites may be an essential mechanism triggering spondyloarthritis.

show abstract

Spondylitis Ankylopoetica. Die sogenannte Bechterewsche Krankheit und ihre Differentialdiagnose (einschließlich Spondylosis hyperostotica, Spondylitis psoriatica und chronisches Reiter-Syndrom)

Schilling¹

1974

Röntgendiagnostik Der Wirbelsäule / Roentgen Diagnosis of the Vertebral Column

View full text Add to dashboard Cite

Uro‐genital Infection of the Male in Relation to Ankylosing Spondylitis and Rheumatoid Arthritis

Cited by 6 publications

References 7 publications

Microbial antigens mediate HLA-B27 diseases via TLRs

Microbial antigens mediate HLA-B27 diseases via TLRs

Autoimmune epididymoorchitis is essential to the pathogenesis of male‐specific spondylarthritis in HLA–B27–transgenic rats

Spondylitis Ankylopoetica. Die sogenannte Bechterewsche Krankheit und ihre Differentialdiagnose (einschließlich Spondylosis hyperostotica, Spondylitis psoriatica und chronisches Reiter-Syndrom)

Contact Info

Product

Resources

About