Urocortin inhibits mesenteric arterial remodeling in spontaneously hypertensive rats

Chen, Jiandong; Tao, Jin; Zhang, Rongjian; Xu, Youhua; Soong, Tuck-Wah; Li, Shengnan

doi:10.1016/j.peptides.2009.02.014

Cited by 9 publications

(7 citation statements)

References 38 publications

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“…Furthermore, long-term Ucn-2 treatment in hypertensive rats diminishes the development of hypertension-induced left ventricular hypertrophy and the deterioration of left ventricular contractile function [43]. Moreover, long-term Ucn treatment not only had hypotensive effects but was also hypothesized to inhibit development of vascular remodeling in mesenteric arteries in spontaneously hypertensive rats [60]. These beneficial effects of Ucn-2 could represent a novel approach for antihypertensive therapy.…”

Section: Ucn-2-crh-r2 Signaling In Other Cardiovascular Diseasesmentioning

confidence: 99%

Urocortin 2 in cardiovascular health and disease

Adão

Santos‐Ribeiro

Rademaker

et al. 2015

Drug Discovery Today

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Section: Ucn-2-crh-r2 Signaling In Other Cardiovascular Diseasesmentioning

confidence: 99%

Urocortin 2 in cardiovascular health and disease

Adão

Santos‐Ribeiro

Rademaker

et al. 2015

Drug Discovery Today

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“…Ucn1 produces the relaxation of human internal mammary artery via the release of endothelial nitric oxide [25] . Administration of Ucn1 into animals reduced plasma concentrations of renin, AngII, and aldosterone [26] , [27] , and inhibited hypertension-induced arterial remodeling (thickness) [28] . Ucn1 suppressed AngII-induced ROS generation in HUVECs [11] , and LPS-induced TNFα release from human trophoblast cells [29] .…”

Section: Discussionmentioning

confidence: 99%

Vasoprotective Effects of Urocortin 1 against Atherosclerosis In Vitro and In Vivo

et al. 2014

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AimAtherosclerosis is the complex lesion that consists of endothelial inflammation, macrophage foam cell formation, vascular smooth muscle cell (VSMC) migration and proliferation, and extracellular matrix production. Human urocortin 1 (Ucn1), a 40-amino acid peptide member of the corticotrophin-releasing factor/urotensin I family, has potent cardiovascular protective effects. This peptide induces potent and long-lasting hypotension and coronary vasodilation. However, the relationship of Ucn1 with atherosclerosis remains unclear. The present study was performed to clarify the effects of Ucn1 on atherosclerosis.MethodsWe assessed the effects of Ucn1 on the inflammatory response and proliferation of human endothelial cells (ECs), human macrophage foam cell formation, migration and proliferation of human VSMCs, extracellular matrix expression in VSMCs, and the development of atherosclerosis in apolipoprotein E-deficient (Apoe −/−) mice.ResultsUcn1 significantly suppressed cell proliferation without inducing apoptosis, and lipopolysaccharide-induced up-regulation of monocyte chemoattractant protein-1 and intercellular adhesion molecule-1 in human ECs. Ucn1 significantly reduced oxidized low-density lipoprotein-induced foam cell formation with a significant down-regulation of CD36 and acyl-CoA:cholesterol acyltransferase 1 in human monocyte-derived macrophages. Ucn1 significantly suppressed the migration and proliferation of human VSMCs and increased the activities of matrix metalloproteinase-2 (MMP2) and MMP9 in human VSMCs. Intraperitoneal injection of Ucn1 into Apoe −/− mice for 4 weeks significantly retarded the development of aortic atherosclerotic lesions.ConclusionsThis study provided the first evidence that Ucn1 prevents the development of atherosclerosis by suppressing EC inflammatory response and proliferation, macrophage foam cell formation, and VSMC migration and proliferation. Thus, Ucn1 could serve as a novel therapeutic target for atherosclerotic cardiovascular diseases.

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“…CRF 2 receptor expression levels are preserved, despite chronic stimulation by Ucn2. Ucn also may play a role in vascular remodeling [40]. Long-term Ucn treatment not only has hypotensive effects but also may inhibit development of vascular remodeling in mesenteric arteries in spontaneously hypertensive rats [40].…”

Section: Roles and Action Of Urocortins In The Vascular Systemmentioning

confidence: 99%

“…Ucn also may play a role in vascular remodeling [40]. Long-term Ucn treatment not only has hypotensive effects but also may inhibit development of vascular remodeling in mesenteric arteries in spontaneously hypertensive rats [40]. Together, CRF 2 receptor stimulation by Ucn2 may represent a novel approach to the treatment of arterial hypertension.…”

Section: Roles and Action Of Urocortins In The Vascular Systemmentioning

confidence: 99%

Regulation and Roles of Urocortins in the Vascular System

Kageyama

Teui

Tamasawa

et al. 2012

International Journal of Endocrinology

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Urocortins (Ucns) are members of the corticotropin-releasing factor (CRF) family of peptides. Ucns would have potent effects on the cardiovascular system via the CRF receptor type 2 (CRF2 receptor). Regulation and roles of each Ucn have been determined in the vascular system. Ucns have more potent vasodilatory effects than CRF. Human umbilical vein endothelial cells (HUVECs) express Ucns1-3 mRNAs, and the receptor, CRF2a receptor mRNA. Ucns1-3 mRNA levels are differentially regulated in HUVECs. Differential regulation of Ucns may suggest differential roles of those in HUVECs. Ucn1 and Ucn2 have strong effects on interleukin (IL)-6 gene expression and secretion in rat aortic smooth muscle A7r5 cells. The increase that we observed in IL-6 levels following Ucn treatment of A7r5 cells suggests that smooth muscle cells may be a source of IL-6 secretion under physiological stress conditions. Ucns are important and unique modulators of vascular smooth muscle cells and act directly or indirectly as autocrine and paracrine factors in the vascular system.

show abstract

Urocortin inhibits mesenteric arterial remodeling in spontaneously hypertensive rats

Cited by 9 publications

References 38 publications

Urocortin 2 in cardiovascular health and disease

Urocortin 2 in cardiovascular health and disease

Vasoprotective Effects of Urocortin 1 against Atherosclerosis In Vitro and In Vivo

Regulation and Roles of Urocortins in the Vascular System

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