Urodynamic and Bladder Diary Factors Predict Overactive Bladder-wet in Women: A Comparison With Overactive Bladder-dry

Abstract

Purpose To identify factors predicting the presence of overactive bladder syndrome (OAB)-wet, compared with OAB-dry. Methods Between September 2007 and September 2013, the medical records of 623 women with OAB who completed a 3-day bladder diary and underwent urodynamic studies in a medical center were retrospectively reviewed. OAB-wet was diagnosed in patients who complained of at least one episode of urgency incontinence in the previous month; otherwise, OAB-dry was diagnosed. Multivariable logistic regression analysis was used to predict the presence of OAB-wet. Results Age (odds ratio [OR], 1.05; P<0.001), maximal flow rate (Qmax) (OR,1.06; P<0.001), voided volume (OR, 0.996; P=0.001), detrusor pressure at maximal flow rate (PdetQmax) (OR, 1.02; P=0.003), urgency episodes (OR, 1.04; P<0.001) and urodynamic stress incontinence (OR,1.78; P=0.01) were independent predictors for the presence of OAB-wet vs. OAB-dry. If we use bladder contractility index as a variable for multivariable logistic regression analysis, bladder contractility index (OR, 1.012; P<0.001) become an independent predictor for OAB-wet. Conclusions A smaller bladder capacity and more frequent urgency episodes were predictors of OAB-wet, and the above findings indicate that OAB-wet and OAB-dry might be a continuum of OAB. Old age, high Qmax, high PdetQmax and urodynamic stress incontinence were also predictors for OAB-wet, and the above results reveal that OAB-wet and OAB-dry have partially different clinical and urodynamic features. Further studies might be performed to elucidate whether different treatment strategies between OAB-dry and OAB-wet can improve treatment efficacy.

Investigating the associations of mucosal P2Y6 receptor expression and urinary ATP and ADP concentrations, with symptoms of overactive bladder

“…As recruitment of participants did not include urodynamics, we therefore cannot definitely rule out a contribution of stress urinary incontinence; however, given that the majority of participants in this part of the analysis were male (18/28), its contribution is likely to be insignificant. Rather, as many patients with OAB do not initially present with incontinence (“OAB dry”), this symptom may, itself, may be seen as further development of the symptom complex 14 and thus P2Y6 expression a phenotype of this development; or “OAB wet” is in itself an OAB phenotype, with a different pathophysiological basis that includes altered P2Y6 expression. Future studies should further investigate the relationship between P2Y6 expression in OAB‐dry and OAB‐wet, and with larger participant numbers.…”

Laparoscopic Long Mesh Surgery with Augmented Round Ligaments: A Novel Uterine Preservation Procedure For Apical Pelvic Organ Prolapse

“…The findings described above suggest that even though LLMS provides fair anatomical reduction, concomitant medical treatment is sometimes needed for the treatment of urgency urinary incontinence and nocturia in these patients. Women with urgency urinary incontinence, or overactive bladder (OAB)-wet, have a small bladder capacity and poor urethral closing mechanism and are usually treated with antimuscarinic agents 21 . Nocturia is a symptom typically associated with OAB 22 .…”

Correlation of incontinence impact questionnaire score in overactive bladder syndrome cases with urodynamic findings

“…Various studies by different authors have confirmed the utility of Qmax and voiding time in OAB. [6][7][8] Overactive bladder syndrome score (OABS) has also been used to diagnose and quantify OAB and is a simple tool taking frequency of urine in day and night, urgency (sudden desire to pass urine and is difficult to defer) and urge incontinence into consideration. Various authors have used OABS for quantification of OAB and to see efficacy of drugs like solifenacin on OAB.…”

“…In fact in diagnosis and quantification of OAB, to find whether detrusor overactivity is present or not, to calculate total urine voided at each micturition (Vmax) and total voiding time. [6][7][8] Urodynamic studies are also used for prognostication of various treatment outcomes including Mirabegron therapy. 8 Yoo et al from South Korea studied prevalence of various lower urinary tract symptoms including OAB in population aged 40 years or over.…”