Urogenital Infection as a Risk Factor for Male Infertility

Schuppe, Hans‐Christian; Pilatz, Adrian; Hossain, Hamid; Diemer, Thorsten; Wagenlehner, Florian M. E.; Weidner, W.

doi:10.3238/arztebl.2017.0339

Cited by 122 publications

(144 citation statements)

References 88 publications

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“…Unlike males suffering from acute urogenital tract infections, most of the affected males counselled for sub/infertility are asymptomatic (Schuppe et al, ). Although the MAGI system is commonly used to characterise these patients by clinical and laboratory findings (Comhaire et al, ; Rowe et al, ; Schuppe et al, ), the diagnostics do not consider STI‐PCR testing (Eley & Pacey, ), lack soluble inflammatory parameters (e.g. cytokines; Pilatz et al, ) and sperm DNA fragmentation (Lotti et al, ), and assume a sterile urogenital tract under normal conditions.…”

Section: Discussionmentioning

confidence: 99%

“…From each native semen sample, 100 µl was used for the comprehensive microbiological workup. Relevant bacteriospermia was diagnosed for common urinary tract pathogens with ≥10 3 CFU/ml (Schuppe et al, ).…”

Section: Methodsmentioning

confidence: 99%

“…In this connection, impaired spermatogenesis and infertility after acute epididymo‐orchitis or mumps orchitis have been reported and histologically confirmed (Osegbe, ; Zhang et al, ). However, the majority of men seeking consultation for couple infertility and suffering from azoospermia are asymptomatic and never report an episode of acute genital tract infection/inflammation (Jungwirth et al, ; Schuppe et al, ). Consequently, it is more common to describe infectious and/or inflammatory conditions of the male genital tract as “male accessory gland infection” (MAGI) (Comhaire, Verschraegen, & Vermeulen, ; Rowe, Comhaire, Hargreave, & Mahmoud, ).…”

Section: Introductionmentioning

confidence: 99%

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High prevalence of urogenital infection/inflammation in patients with azoospermia does not impede surgical sperm retrieval

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Considering infection/inflammation to be an important risk factor in male infertility, the aim of this study was to make a comprehensive evaluation of the prevalence of urogenital tract infection/inflammation and its potential impact on sperm retrieval in azoospermic patients. In this prospective study, 71 patients with azoospermia were subjected to an extensive andrological workup including comprehensive microbiological diagnostics (2-glass test, semen, testicular swab and testicular tissue analysis) and testicular biopsy/testicular sperm extraction (TESE). Medical history suggested urogenital tract infection/inflammation in 7% of patients, 11% harboured STIs, 14% showed significant bacteriospermia, 15% had seminal inflammation, 17% fulfilled the MAGI definition, and 27% had relevant pathogens. At the testicular level, 1 patient had a swab positive for bacteria, no viruses were detected, tissue specimens never indicated pathogens, whereas histopathology revealed focal immune cell infiltrates in 23% of samples. Testicular sperm retrieval rate was 100% in obstructive and 46% in nonobstructive azoospermia. None of the infection/inflammation-related variables was associated with the success of sperm retrieval or inflammatory lesions in the testis. The high prevalence of urogenital infection/inflammation among azoospermic men underpins their role as significant aetiologic factors in male infertility.However, this observation does not refer to the chances of sperm retrieval at the time of surgery/TESE. K E Y W O R D Sazoospermia, genital tract inflammation, infertility, male accessory gland infection, TESE 2 of 10 | PILATZ eT AL.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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High prevalence of urogenital infection/inflammation in patients with azoospermia does not impede surgical sperm retrieval

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“…Безусловно, влияние оказывает и то, в какой стране проводились исследования. Однако вполне уверенно можно говорить о том, что веду-щими факторами, которые оказывают наиболь-шее влияние на мужскую фертильность, являются последствия урогенитальных инфекций, в том чис-ле вирусных [12][13][14], и связанные с этим наруше-ния иммунной системы, патологии яичек и пред-стательной железы (варикоцеле, эпидидимоорхит, простатит) [15][16][17][18][19], а также эндокринные наруше-ния [20,21]. Хронический неспеци фический про-статит (ХНП), по разным данным, вызывает ин-фертильность в 52-76 % случаев [22][23][24][25].…”

Section: воздействие окружающей средыunclassified

Experimental justification of laser therapy efficiency of men's infertility

et al. 2017

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Male infertility is a multifactorial syndrome, which includes a wide range of disorders. It is a symptom of many different pathological conditions affecting both the reproductive and other body systems: endocrine, nervous, blood-vascular, and immune systems. Low level laser therapy is a method of modern physiotherapy, in which the impact is carried out by low-intensity laser irradiation (LILI). It is widely used in all areas of modern medicine, due to its high efficiency, simplicity of use, the absence of contraindications and side effects. The results of russian and foreign experimental studies on the article subject were analyzed. A definite conclusion is drawn that low level laser therapy should be used as much as possible in the complex treatment of men with infertility, since the effectiveness of the method is not just high, but often has no alternatives. At the same time, the available low level laser therapy techniques should be widely used: locally, rectally, laser acupuncture, ILBI (intravenous laser blood irradiation), on the projection of various organs, paravertebrally, etc. All parameters of laser action should be set (wavelength; mode of operation; frequency for pulsed lasers; power; power density, determined by the method of exposure; exposure, localization), which are specified by the relevant regulatory documents and clinical recommendations. (For citation: Moskvin SV, Borovets SJu, Toropov VA. Experimental justification of laser therapy efficiency of men's infertility. Urologicheskie vedomosti. 2017;7(4):44-53. doi: 10.17816/uroved7444-53).

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“…Infections of the urogenital tract are believed to be of considerable significance in determining fertility outcome in males. Globally, they account for about 15% of these male infertility cases [1]. These infections lead to perturbation in male genital tract, thereby, damaging important biological functions of the organs of reproductive system.…”

Section: Introductionmentioning

confidence: 99%

Alterations in human sperm parameters as a corollary of incubation with various uropathogenic microorganisms

Vander¹,

Prabha²

2019

Gynecol Reproduct Endocrinol

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Purpose: To analyze the impact of different uropathogenic microorganisms on various sperm parameters those are generally used to determine male fertilizing potential. Method: The standard strains viz. Serratia marcescens, Klebsiella pneumoniae, Enterobacter aerogenes, Candida albicans, Proteus mirabilis, Streptococcus pyogenes, Klebsiella oxytoca were checked for their impact on sperm motility, viability, morphology, Mg ++ ATPase activity and acrosome status of spermatozoa.Results: S. marcescens, K. pneumoniae, E. aerogenes compromised sperm motility via agglutination and C. albicans impaired motility without agglutination. Further, these strains could also reduce viability resulting in sperm death. These strains induced morphological defects in spermatozoa as evident by electron microscopic studies. Incubation of spermatozoa with these uropathogenic strains led to reduction in Mg 2+ dependent ATPase activity and also resulted in premature acrosomal loss. On the other hand, P. mirabilis, S. pyogenes, K. oxytoca did not alter any of these parameters.Conclusion: It can be concluded from the present study that certain uropathogenic strains can induce detrimental effects on spermatozoon thereby reducing its fertilizing ability. AbstractCitation: Vander H, Prabha V. Alterations in human sperm parameters as a corollary of incubation with various uropathogenic microorganisms.

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Urogenital Infection as a Risk Factor for Male Infertility

Cited by 122 publications

References 88 publications

High prevalence of urogenital infection/inflammation in patients with azoospermia does not impede surgical sperm retrieval

High prevalence of urogenital infection/inflammation in patients with azoospermia does not impede surgical sperm retrieval

Experimental justification of laser therapy efficiency of men's infertility

Alterations in human sperm parameters as a corollary of incubation with various uropathogenic microorganisms

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