Urogenital tuberculosis — epidemiology, pathogenesis and clinical features

Muneer, Asıf; Macrae, Bruce; Krishnamoorthy, Sriram; Zumla, Alimuddin

doi:10.1038/s41585-019-0228-9

Cited by 134 publications

(183 citation statements)

References 249 publications

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“…This form of TB is unusual in immunocompetent patients and corresponds to less than 2% of all TB cases. Disseminated TB is defined by lung injury associated with an extrapulmonary focus or two or more concomitant extrapulmonary lesions [1,2,3].…”

Section: Discussionmentioning

confidence: 99%

“…The most commonly affected sites for EPTB are lymph nodes [2,4]. Of all forms of EPTB, UGTB ranges from 2% to 20% according to the geographical region and represents 0.2% to 21% of infertility cases [1,2]. It is difficult to estimate the exact prevalence of UGTB because patients can be asymptomatic.…”

Section: Discussionmentioning

confidence: 99%

“…UGTB is the third most common form of EPTB in low incidence countries. In Europe, UGTB is diagnosed more often in migrants [1,2,3].…”

Section: Discussionmentioning

confidence: 99%

“…Usually, UGTB arises from pulmonary spread of the bacilli directly via hematogenous or lymphatic seeding. The order of frequency of urogenital track involvement is kidney, bladder, fallopian tube, and scrotum [1,2,5].…”

Section: Discussionmentioning

confidence: 99%

“…TB can affect every organ [1]. Off all forms of extrapulmonary TB (EPTB) urogenital TB (UGTB) varies according to geographical region, from 2 to 20% [1,2].…”

Section: Introductionmentioning

confidence: 99%

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Two Sites - One Major Problem

Silvestre¹,

Nunes²,

Cordeiro³

et al. 2020

AJMCR

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The authors present the case of a 36-year-old woman with disseminated tuberculosis shown by pulmonary nodules and urogenital involvement. Positive cultures for Mycobacterium tuberculosis in urine and bronchial secretions made the diagnosis. After three months of multidrug treatment, there was a clinical and radiologic improvement. This case highlights an uncommon case of an immunocompetent patient with disseminated tuberculosis. A delay in the diagnosis of pulmonary tuberculosis can result in serious public health problems with disease spread.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…UGTB is the third most common form of EPTB in low incidence countries. In Europe, UGTB is diagnosed more often in migrants [1,2,3].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…TB can affect every organ [1]. Off all forms of extrapulmonary TB (EPTB) urogenital TB (UGTB) varies according to geographical region, from 2 to 20% [1,2].…”

Section: Introductionmentioning

confidence: 99%

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Two Sites - One Major Problem

Silvestre¹,

Nunes²,

Cordeiro³

et al. 2020

AJMCR

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Indolent renal involvement with BRAF^V600E mutation: Erdheim‐Chester, a rare disease with a wide spectrum of clinical manifestations

Vanhomwegen

Mestrez

Faverly

et al. 2021

Clinical Case Reports

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We present the case of a patient with three‐year indolent bilateral ureteral and perirenal masses. Clinical presentation, radiological context, and histopathological findings with detection of BRAF V600E mutation confirmed the diagnosis of Erdheim‐Chester disease (ECD). A review of current knowledge regarding diagnosis, clinical assessment, management, and treatment of ECD is also presented.

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