Urolithiasis as an extraarticular manifestation of ankylosing spondylitis

Korkmaz, Cengiz; Sayer, John A.

doi:10.1007/s00296-017-3788-0

Cited by 13 publications

(7 citation statements)

References 68 publications

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“…Eliah et al 13 claimed that limited spinal mobility and pyelo-pelvic position in AS patients might be an underlying predisposing factor for urolithiasis. Korkmaz et al 14 suggested that one of the mechanisms responsible for the development of urolithiasis in AS may be intestinal inflammation as a result of enteric hyperoxaluria. Bone turnover and bone resorption activated by inflammatory cytokines can also cause hypercalciuria.…”

Section: Discussionmentioning

confidence: 99%

Sulfasalazine related nephrolithiasis in patients with rheumatoid arthritis and ankylosing spondylitis

KUZGUN¹,

MURAT²,

Özkök

et al. 2022

Turkish Journal of Internal Medicine

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Background Sulfasalazine (SSZ) is an anti-inflammatory and immunomodulatory drug used to treat many inflammatory diseases. Bacteria in the gut metabolize SSZ to active 5-aminosalicylic acid and inactive sulfapyridine. Sulfapyridine can crystallize in the kidney. We aimed to investigate the frequency of nephrolithiasis in patients who were diagnosed with rheumatoid arthritis (RA), ankylosing spondylitis (AS) and who received SSZ treatment retrospectively. Material and Methods We retrospectively analyzed the files of AS and RA patients in the rheumatology outpatient clinic between 2009 and 2018. We identified patients who underwent kidney ultrasonography at least six months after initiation of SSZ. One hundred six patients and 50 healthy adults were included in the study. Results Only eight patients (6 AS, 2 RA) had nephrolithiasis on ultrasonography, but none in the control group (p=0.046). In logistic regression analysis, no correlation was found between gender, age, vitamin D, parathyroid hormone, and urinary calcium excretion with SSZ use (p>0.05). Conclusion Although, it is noteworthy that these patients are prone to stone formation for various reasons. Therefore, paying attention to the patient’s hydration while using these drugs may prevent such side effects.

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Section: Discussionmentioning

confidence: 99%

Sulfasalazine related nephrolithiasis in patients with rheumatoid arthritis and ankylosing spondylitis

KUZGUN¹,

MURAT²,

Özkök

et al. 2022

Turkish Journal of Internal Medicine

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“…21 Ankylosing spondylitis (AS), which is the most common type of spondyloarthritis (SpA), is a chronic inflammatory disease that affects the axial and sacroiliac joints. 22 AS often affects extraarticular organs such as the eyes, lungs, bowels, and heart, and urolithiasis is frequently observed in this disease. 22 A study showed that patients with SpA had a higher incidence of kidney stones than those with RA, and it was speculated that SpA was an independent risk factor for nephrolithiasis.…”

Section: Ta B L E 4 Demographic and Clinical Characteristics Of Patie...mentioning

confidence: 99%

Single‐center survey of incidental imaging findings on computed tomography in patients with psoriasis on biologic therapy

SUGIHARA

Kado

Kishimoto

et al. 2023

The Journal of Dermatology

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Psoriasis is one of the most common chronic inflammatory skin diseases and predominantly affects the skin and joints. 1,2 Various comorbidities and risk factors interact with each other and affect the pathogenesis of psoriasis. 3 Metabolic syndrome is strongly associated with the onset and exacerbation of psoriasis, and patients with psoriasis are at increased risk of cardiovascular disease, which is ascribed not only to metabolic syndrome but also to chronic systemic inflammation. 4 Additionally, patients with psoriasis have an increased risk of cancer. 5 Recently, the concept of psoriatic march has been widely accepted in the pathogenesis of psoriasis. 6 In patients with moderate-to-severe psoriasis, systemic therapies are required to control the disease, and biologics can provide significant

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“…Korkmaz et al summarized the previous research on the incidence rate of urolithiasis in patients with AS from 1972 to 2015 and found that the rate ranged from 1.6% to 29.11% with 0.7% to 12.5% in general population. They eventually concluded that urolithiasis was an extra-articular manifestation of AS (2).…”

Section: Introductionmentioning

confidence: 99%

Efficacy and safety of ultrasound-guided percutaneous nephrolithotomy for kidney calculi patients with ankylosing spondylitis: a retrospective single center analysis

Xia

Hong

An³

et al. 2021

Ann Palliat Med

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Background: To investigate the efficacy and safety of ultrasound-guided percutaneous nephrolithotomy (PCNL) in kidney calculi patients with ankylosing spondylitis (AS).Methods: The data of 22 renal stone patients (25 kidney units) with AS who underwent PCNL in our institute from January 2008 to December 2019 were analyzed retrospectively. General information of these patients, intraoperative and postoperative data were recorded. The primary parameter for efficacy was initial and final stone free rates (SFR) with X-ray kidney, ureter, and bladder (KUB) were performed 1 st or 2 nd day and 1 month after surgery. Preoperative and postoperative laboratory results, surgical procedures and the occurrence of postoperative complications were used to identify the safety PCNL intervention.Results: Most PCNLs were performed with general anesthesia (76%) and prone position (64%). The initial SFR and final SFR were 80% (20 kidney units) and 88% (22 kidney units) respectively. Haemoglobin decreased after PCNL occurred in 22 patients (88.0%) and the mean postoperative hemoglobin drop was 1.32±0.76 g/L (range, 0.10-3.10 g/L), with one patient received blood transfusion. One patient developed postoperative fever (T >38.5 ℃). No other complications such as colon injury, extravasation of urine, perinephric infection and urosepsis occurred. Conclusions:The result of ultrasound-guided PCNL for kidney stone patients with AS is satisfactory with high SFR and security. Operative position, anesthesia method and damage caused by drugs used in the treatment of AS should be considered to achieve better result.

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Urolithiasis as an extraarticular manifestation of ankylosing spondylitis

Cited by 13 publications

References 68 publications

Sulfasalazine related nephrolithiasis in patients with rheumatoid arthritis and ankylosing spondylitis

Sulfasalazine related nephrolithiasis in patients with rheumatoid arthritis and ankylosing spondylitis

Single‐center survey of incidental imaging findings on computed tomography in patients with psoriasis on biologic therapy

Efficacy and safety of ultrasound-guided percutaneous nephrolithotomy for kidney calculi patients with ankylosing spondylitis: a retrospective single center analysis

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