Urolithiasis in Lichen planus

Kumar, Bhushan; Sethuraman, Gomathy; Khandelwal, N.; Kaur, Inderjeet

doi:10.1159/000018269

Cited by 3 publications

(7 citation statements)

References 2 publications

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“…Our results demonstrated a 20% prevalence of urolithiasis in patients with LP, which can be considered similar to previous studies ( 6 , 15 ). In 5% of the patients, a renal calculus at the time of presentation was detected.…”

Section: Discussionsupporting

confidence: 92%

“…Unlike previous literature ( 16 ), their results were similar between the patient and control groups. The authors concluded that the only noticeable result of their study was that the serum uric acid and urine calcium levels and prior history of urolithiasis were significantly higher in the patients with LP compared to the control group ( 6 ). We think an important limitation of their study was that they did not investigate other lithogenic factors, such as urine oxalate, citrate, magnesium or sodium levels, which can be considered important risk factors for urolithiasis ( 17 ).…”

Section: Discussionmentioning

confidence: 95%

“…Urolithiasis is a common disease that effects approximately 11% of the adult population. To date, a limited number of studies have evaluated the association of urolithiasis and LP ( 6 , 14 - 16 ). Halevy et al reported the coexistence of LP and urolithiasis for the first time in 1983 ( 15 ) From medical records and anamnesis, they found that 14.6% of 130 patients with LP had a history of urolithiasis.…”

Section: Discussionmentioning

confidence: 99%

“…According to their results, they concluded that there could be involvement of metabolic disorders in LP. The last article on this topic was published by Kumar et al in 1999 ( 6 ) and included 75 patients with LP and 62 healthy individuals. Nine (12%) of those patients had a history of urolithiasis.…”

Section: Discussionmentioning

confidence: 99%

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Are patients with lichen planus really prone to urolithiasis? Lichen planus and urolithiasis

et al. 2016

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Purpose to investigate whether patients with lichen planus (LP) are really prone to urolithiasis or not.Patients and Methods We performed a prospective analysis of 40 patients diagnosed with lichen planus (LP) (group I), and 40 volunteers did not have LP before (group II). Participants were all checked for urolithiasis by radiological investigations. Blood samples were analyzed for biochemistry parameters including calcium and uric acid. 24-h urine samples were analyzed to investigate oxalate, citrate calcium, uric acid, magnesium, sodium and creatinine.Results Men/women ratio and mean age were similar between group I and II (p>0.05). A presence or history of urolithiasis was detected in 8 (20%) and 2 (%5) patients in group I and II, respectively (p<0.05). Hypocitraturia was the most common anomaly with 35% (n:14) in group I. The rate of hypocitraturia in group II was 12.5% (n:5) and the difference was statistically significantly different (p=0.036). In group I, hyperuricosuria and hyperoxaluria followed with rates of 27.5% (n:11) and 25% (n:10), respectively. The rate of hyperuricosuria and hyperoxaluria were both 5% (n:2) in group II and the differences were significant (p<0.05). Hyperuricemia was another important finding in the patients with LP. It was detected in 13 (32.5%) patients in group I and in 1 (2.5%) participant in group II (p=0.001).Conclusion According to our results, metabolic disorders of urolithiasis were highly detected in the patients with LP. However, similar to the etiology of LP, the exact reasons for these metabolic abnormalities in LP remain a mystery.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Are patients with lichen planus really prone to urolithiasis? Lichen planus and urolithiasis

et al. 2016

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“…60 This study was not a true open trial, but rather a summary of the experience of these authors in the use of dapsone. No criteria for efficacy were available in this letter.…”

Section: Various Drugsmentioning

confidence: 99%

Treatment of Lichen Planus

Cribier

Françès²,

Chosidow³

1998

Arch Dermatol

176

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To critically appraise the body of literature concerning treatment of lichen planus (LP).Design: Review of MEDLINE and BIOSIS databases to identify articles published with at least an English abstract before March 1998 that examined treatment of LP.Main Outcome Measures: Forming a primary database on which most recommendations are based. We thus selected 83 clinical trials or small series of patients in the medical literature that referenced clinical data on patients treated for LP.Results: There are no large randomized trials with definitive results in the medical literature examining the efficacy of the various drugs or physical treatments of LP. There are only 3 level B trials (small randomized trials with uncertain results because of moderate to high ␣ or ␤ error) that address efficacy of treatment in LP, ie, 1 with acitretin in cu-

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Lichen Planus: A Clinical and Epidemiological Study

Bhattacharya

Kaur

Kumar

2000

The Journal of Dermatology

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Clinical and epidemiological data from 232 patients with lichen planus is presented. Lichen planus constituted 0.38% of the total dermatology, outpatients diagnosed. The patient ages ranged from 8 to 76 years, most being in the age range from 20 to 49 years. Duration of disease varied from 1 month to 7 years. Both sexes were equally affected. The majority of the patients (47.4%) had classical lesions followed by hypertrophic and actinic lichen planus next in frequency. Itching was the predominant symptom in 79.3%. Limbs were the most frequent initial site of onset (55.6%). Mucosal involvement along with cutaneous lesions were observed in 16.8% and genital involvement in only 5.2%. Nail changes were observed in 15.1% of patients. A history of recurrence of the disease was obtained from 10.3% of patients. Liver disease was found to be associated in 2.2% of patients. No malignant changes were observed in any of the lesions of lichen planus.

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Urolithiasis in Lichen planus

Cited by 3 publications

References 2 publications

Are patients with lichen planus really prone to urolithiasis? Lichen planus and urolithiasis

Are patients with lichen planus really prone to urolithiasis? Lichen planus and urolithiasis

Treatment of Lichen Planus

Lichen Planus: A Clinical and Epidemiological Study

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