Urolithin B suppresses tumor growth in hepatocellular carcinoma through inducing the inactivation of Wnt/β‐catenin signaling

Lv, Min‐Yi; Shi, Chuan-Jian; Pan, Feifei; Shao, Jiang; Lu, Feng; Chen, Guoqin; Ou, Caiwen; Zhang, Jinfang; Fu, Weiming

doi:10.1002/jcb.28989

Cited by 49 publications

(40 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Uro-B treatment also induced apoptosis, which is evident from the decreased protein expression of Bcl-2. In vivo , Uro-B (40 mg/kg) suppressed tumor growth in a xenograft mice model ( 100 ). Uro-B's antiproliferative potential in both in vivo and in vitro is associated with an increase in phosphorylation of β-catenin, blocking its translocation from the nucleus to the cytoplasm and resulted in the inactivation of Wnt/β-catenin signaling ( 61 , 100 ).…”

Section: Hepatocellular Carcinomamentioning

confidence: 99%

Urolithins: The Gut Based Polyphenol Metabolites of Ellagitannins in Cancer Prevention, a Review

et al. 2021

View full text Add to dashboard Cite

Cancer as a disease continues to ravage the world population without regard to sex, age, and race. Due to the growing number of cases worldwide, cancer exerts a significant negative impact on global health and the economy. Interestingly, chemotherapy has been used over the years as a therapeutic intervention against cancer. However, high cost, resistance, and toxic by-effects to treatment have overshadowed some of its benefits. In recent times, efforts have been ongoing in searching for anticancer therapeutics of plant origin, focusing on polyphenols. Urolithins are secondary polyphenol metabolites derived from the gut microbial action on ellagitannins and ellagic acid-rich foods such as pomegranate, berries, and nuts. Urolithins are emerging as a new class of anticancer compounds that can mediate their cancer-preventive activities through cell cycle arrest, aromatase inhibition, induction of apoptosis, tumor suppression, promotion of autophagy, and senescence, transcriptional regulation of oncogenes, and growth factor receptors. In this review, we discussed the growing shreds of evidence supporting these secondary phenolic metabolites' anticancer properties. Furthermore, we have pointed out some of the future directions needed to establish urolithins as anticancer agents.

show abstract

Section: Hepatocellular Carcinomamentioning

confidence: 99%

Urolithins: The Gut Based Polyphenol Metabolites of Ellagitannins in Cancer Prevention, a Review

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Sulindac has exhibited the property to induce apoptosis and proliferative inhibition in HepG2 liver cancer cells (Wu et al, 2001). Presently urolithins have been reported to exhibit antiproliferative properties by blocking the translocation of β‐catenin from nucleus to cytoplasm, resulting in the inactivation of Wnt/β‐catenin signal transduction in liver cancer cells (Lv et al, 2019). Keeping in view the significant impact of Wnt/β‐catenin signal transduction on liver regeneration mechanisms and the self‐renewal of pluripotent stem cells, its functionality can pave the way for establishing novel therapies to combat HCC.…”

Section: Molecular Pathways and Targeted Therapies Involvedmentioning

confidence: 99%

Targeting molecular signal transduction pathways in hepatocellular carcinoma and its implications for cancer therapy

Mir

Guha

Behera

et al. 2021

Cell Biology International

View full text Add to dashboard Cite

Hepatocellular carcinoma is a substantial health concern. It is currently the third dominating cause of mortality associated with cancer worldwide. The development of hepatocellular carcinoma is an intricate process that encompasses the impairment of genetic, epigenetic, and signal transduction mechanisms contributing to an aberrant metabolic system, enabling tumorigenesis. Throughout the past decade, research has led to the revelation of molecular pathways implicated in the progression of this notorious disorder. The altered signal transduction pathways, such as the mitogen‐activated protein kinase pathway, phosphoinositol 3‐kinase/protein kinase B/mammalian target of rapamycin pathway, WNT/β‐catenin pathway, hepatocyte growth factor/c‐MET pathway, and just another kinase/signal transducers and activators of transcription signaling pathway is of much therapeutic significance, as targeting them may avail to revert, retard or avert hepatocarcinogenesis. The present review article sums up the contemporary knowledge of such signaling mechanisms, including their therapeutic targets and betokens that novel and efficacious therapies can be developed only by the keen understanding of their character in hepatocarcinogenesis. In additament, we address the role of consequential therapeutic agents and preclinical nondrug therapies known for combating hepatocarcinogenesis.

show abstract

“…Experiments were conducted as mentioned before [20]. In brief, HEK293 cells were seeded on a 24-well plate, and the cells were allowed to grow until 80% con uency.…”

Section: Luciferase Reporter Assaysmentioning

confidence: 99%

Hydroxysafflor yellow A promotes osteogenesis and bone development via epigenetically regulating β-catenin and prevents ovariectomy-induced bone loss

Wang

Zhuo

et al. 2021

The International Journal of Biochemistry & Cell Biology

View full text Add to dashboard Cite

Objectives: Mesenchymal stem cells (MSCs) forming excessive adipocytes has been proven to be the pathogenesis of osteoporosis, leaving the bone more fragile. The approaches to promoting osteogenesis of MSCs are regarded as the promising direction to prevent osteoporosis. In clinical treatment, there is increasingly prevalent that traditional Chinese medicine treats common bone diseases including osteoporosis. HuoXue Tong Luo capsule (HXTL capsule) containing Sa ower, Angelica sinensisetc, is one of the most frequently used prescriptions for osteoporosis with promising effects. In our study, we have demonstrated Hydroxysa or yellow A (HSYA), belonging to one of essential compounds of Sa ower, promote bone development and inhibit ovariectomized osteoporosis and explored its potential mechanisms in vitro.Materials and methods: We rst investigated the effects of HSYA on viability and osteogenesis in human bone marrow-derived mesenchymal stem cells (hBMSCs). RNA sequencing analysis and ChIP assay were conducted to nd out the potential mechanism of bone formation effect of HSYA. In vivo, through the chick embryo and ovariectomy (OVX)-induced osteoporosis rat model, we analyzed the function of bone development and formation of HSYA.Results: Taken all the results of our experiments together, it is safe to conclude that HSYA can promote osteogenesis via KDM7A as an epigenetic role to activate histone demethylation in β-catenin. More importantly, our study indicated that HSYA could promote bone development and protect against OVXinduced bone loss. Conclusion:These ndings could pave the way to the potential development of HSYA-targeted therapeutic treatments for skeletal diseases such as osteoporosis.

show abstract

Urolithin B suppresses tumor growth in hepatocellular carcinoma through inducing the inactivation of Wnt/β‐catenin signaling

Cited by 49 publications

References 49 publications

Urolithins: The Gut Based Polyphenol Metabolites of Ellagitannins in Cancer Prevention, a Review

Urolithins: The Gut Based Polyphenol Metabolites of Ellagitannins in Cancer Prevention, a Review

Targeting molecular signal transduction pathways in hepatocellular carcinoma and its implications for cancer therapy

Hydroxysafflor yellow A promotes osteogenesis and bone development via epigenetically regulating β-catenin and prevents ovariectomy-induced bone loss

Contact Info

Product

Resources

About