Urologic Aspects of HIV Infection

Shindel, A.W.; Akhavan, Ardavan; Sharlip, Ira D.

doi:10.1016/j.mcna.2010.08.017

Cited by 11 publications

(3 citation statements)

References 93 publications

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“…We demonstrated an 18% prevalence of ED among MSM participating in the MACS, similar to a U.S. population‐based estimate of 18.4% using data from the 2001–2002 National Health and Nutrition Examination Survey [4]. However, the prevalence of ED was higher among the HIV+ men compared with the HIV− men in our sample, similar to other research [27]. As well, the correlates of ED differed by HIV status.…”

Section: Discussionsupporting

confidence: 88%

The Cumulative Effects of Medication Use, Drug Use, and Smoking on Erectile Dysfunction Among Men Who Have Sex with Men

Hart

Moskowitz

Cox

et al. 2012

The Journal of Sexual Medicine

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Introduction Erectile dysfunction (ED) is highly prevalent among Human Immunodeficiency Virus-seropositive (HIV+) men who have sex with men (MSM). There is a need for additional research to determine the correlates of HIV+ and HIV-seronegative (HIV−) MSM, especially regarding non-antiretroviral medication use. Aims This study examined the prevalence of ED and the socio-demographic, medical conditions, medication use, and substance use correlates of ED among HIV+ and HIV− MSM. Methods A modified version of the International Index of Erectile Function (IIEF) for MSM was self-administered by participants enrolled in the Multicenter AIDS Cohort Study (MACS), an ongoing prospective study of the natural and treated histories of HIV infection among MSM in the United States. The study sample included 1,340 participants, including 612 HIV+ and 728 HIV− men. Poisson regression with robust error variance was used to estimate prevalence ratios of ED in multivariable models in combined (HIV+/−) and separate analyses. Main outcome measure ED was determined by the summed scores of a modified version of the IIEF validated among MSM. Results Twenty-one percent of HIV+ MSM and 16% of HIV− MSM reported ED. Being >55 years of age, Black race, cumulative pack-years of smoking, cumulative antihypertensive use, and cumulative antidepressant use had significant positive associations with the prevalence of ED in the total sample. Among HIV+ men, duration of antihypertensive use and antidepressant use were significantly associated with increasing prevalence of ED. Among HIV− men, being >55 years of age, Black race, and cigarette smoking duration were associated with increased prevalence of ED. Conclusion Predictors of ED may differ by HIV status.. Although smoking cessation and effective medication management may be important as possible treatment strategies for ED among all MSM, there may be a burden on sexual functioning produced by non-HIV medications for HIV+ men.

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Section: Discussionsupporting

confidence: 88%

The Cumulative Effects of Medication Use, Drug Use, and Smoking on Erectile Dysfunction Among Men Who Have Sex with Men

Hart

Moskowitz

Cox

et al. 2012

The Journal of Sexual Medicine

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“…Another study showed an increased prevalence of urinary tract infections in both HIV positive men and women, but did not address urinary symptoms outside of infections. [19] Our study adds to the literature, by using validated questionnaires to determine the rate of LUTS and urinary incontinence, as well as their associated factors, in a clinically well-managed population of WLWH.…”

Section: Discussionmentioning

confidence: 99%

Urinary symptoms and quality of life in women living with HIV: a cross-sectional study

et al. 2020

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“…The management of urinary symptoms in women with HIV is relevant for individual patients and public health since the low urogenital tract is a vector for HIV infection [88].…”

Section: Low Urinary Tract Symptomsmentioning

confidence: 99%

Low genitourinary tract risks in women living with the human immunodeficiency virus

et al. 2023

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This review analyzes the clinical associations between specific low genitourinary tract clinical circumstances in peri-and postmenopausal women living with human immunodeficiency virus (WLHIV). Modern antiretroviral therapy (ART) improves survival and reduces opportunistic infections and HIV transmission. Despite appropriate ART, WLHIV may display menstrual dysfunction, risk of early menopause, vaginal microbiome alterations, vaginal dryness, dyspareunia, vasomotor symptoms, and low sexual function as compared to women without the infection. They have increased risks of intraepithelial and invasive cervical, vaginal, and vulvar cancers. The reduced immunity capacity may also increase the risk of urinary tract infections, side effects or toxicity of ARTs, and opportunistic infections, Menstrual dysfunction and early menopause may contribute to the early onset of vascular atherosclerosis and plaque formation, and increased osteoporosis risks requiring specific early interventions. On the other hand, the association between being postmenopausal and having a low sexual function is significant and related to low adherence to ART. WLHIV deserve a specific approach to manage different low genitourinary risks and complications related to hormone dysfunction and early menopause.

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Urologic Aspects of HIV Infection

Cited by 11 publications

References 93 publications

The Cumulative Effects of Medication Use, Drug Use, and Smoking on Erectile Dysfunction Among Men Who Have Sex with Men

The Cumulative Effects of Medication Use, Drug Use, and Smoking on Erectile Dysfunction Among Men Who Have Sex with Men

Urinary symptoms and quality of life in women living with HIV: a cross-sectional study

Low genitourinary tract risks in women living with the human immunodeficiency virus

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