Urologic chronic pelvic pain

Potts, Jeannette M.; Payne, Christopher K.

doi:10.1016/j.pain.2011.10.005

Cited by 29 publications

(18 citation statements)

References 26 publications

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“…A substantial body of research has explored bladder pathology and other peripheral tissue abnormalities, however, a large number of IC/BPS patients lack any discernible end organ inflammation, and do not respond to treatment of peripheral tissues (e.g. hydrodistension of bladder) [31]. This suggests that investigation of more systemic factors (e.g., inflammation, inflammatory control) may yield important insights.…”

Section: Introductionmentioning

confidence: 99%

Inflammation and inflammatory control in interstitial cystitis/bladder pain syndrome: Associations with painful symptoms

Schrepf

O’Donnell

Luo

et al. 2014

Pain

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Section: Introductionmentioning

confidence: 99%

Inflammation and inflammatory control in interstitial cystitis/bladder pain syndrome: Associations with painful symptoms

Schrepf

O’Donnell

Luo

et al. 2014

Pain

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“…Interstitial cystitis/bladder pain syndrome (IC/BPS)[2] has been diagnosed primarily in women while chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS)[3] is a diagnosis exclusive to men. Although historically these conditions have been studied separately, more recent views stress that male and female UCPPS share many common features including features in common with other chronic pain conditions[4, 5]. …”

mentioning

confidence: 99%

Widespread Psychosocial Difficulties in Men and Women With Urologic Chronic Pelvic Pain Syndromes: Case-control Findings From the Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network

Naliboff

Stephens

Afari

et al. 2015

Urology

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Objectives To determine the extent, severity and sex differences of psychosocial deficits in men and women with urologic chronic pelvic pain syndromes (UCPPS), which in the past have been considered separate bladder (Interstitial Cystitis/Painful Bladder Syndrome) and prostate (Chronic Prostatitis/Chronic Pelvic Pain Syndrome) disorders. Evaluations of men and women separately suggest UCPPS is associated with increased anxiety and depression. However, studies directly testing deficits in broader psychosocial domains such as cognitive processes, intimate relationships and trauma history, or tests of sex differences in the pattern of difficulties associated with UCPPS have not been performed. Methods A total of 233 female and 191 male UCPPS patients and 235 female and 182 male healthy controls (HCs) were recruited from six academic medical centers in the US and evaluated with a comprehensive battery of symptom, psychosocial, and illness impact measures. Primary comparisons of interest were between UCPPS patients and HC, and between men and women with UCPPS. Results In addition to greater negative affect, male and female UCPPS patients show higher levels of current and lifetime stress, poorer illness coping, increased self-report of cognitive deficits and more widespread pain symptoms compared to sex and education matched HC. Similar problems were found in male and female UCPPS although female UCPPS showed increased self-report of childhood adversity and more widespread symptoms of pain and discomfort. Conclusions Given the significance of psychosocial variables in prognosis and treatment of chronic pain conditions, the results add substantially to our understanding of the breath of difficulties associated with UCPPS and point to important areas for clinical assessment.

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“…More recent conceptualizations of CPPS explore various other pain mechanisms, which are potentially part of a larger functional somatic syndrome. 5 While multiple mechanisms have been proposed, the heterogeneity of this disorder makes clear definitions difficult.…”

mentioning

confidence: 99%