“…Reduced healing capacity due to ischemia makes the bladder susceptible to mucosal ulceration, hemorrhage, occasional spontaneous perforation and fistula formation. 2,3 Bladder tissue examined histologically during the chronic phase of radiation cystitis, particularly in patients with gross hematuria, may exhibit surface denudation, ulceration, stromal hem- orrhage and edema, fibrin deposition in stroma and blood vessels, fibrosis, and acute and chronic inflammation, sometimes with prominent eosinophilia (figs. 1 and 2).…”