Urologic Considerations in Pediatric Chronic Kidney Disease

Lombel, Rebecca M.; Brakeman, Paul; Sack, Bryan S.; Butani, Lavjay

doi:10.1053/j.ackd.2022.02.006

Cited by 16 publications

(4 citation statements)

References 77 publications

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“…Devido a doença renal crônica ser uma comorbidade com desencadeamento sistêmico com diversas manifestações de longo prazo e por ser prejudicial ao desenvolvimento infantil, é fundamental que os pacientes pediátricos tenham seu desenvolvimento e sua transição para a vida adulta acompanhados criteriosamente (TANGIRALA S, et al, 2018). Diferentes formas de CAKUT podem evoluir para doença renal crônica: somente um rim funcional, válvula de uretra posterior, hidronefrose antenatal, refluxo vesicoureteral, disfunção de bexiga neurogênica (LOMBEL RM, et al, 2022). De acordo com a teoria da hiperfiltração glomerular de Brenner, menor quantidade de néfrons levam à hiperfiltração glomerular compensatória.…”

Section: Doença Renal Crônicaunclassified

“…Essas anomalias congênitas são consideradas como os principais fatores contribuintes para o surgimento da Doença Renal Crônica (DRC), essencialmente na população infantilaproximadamente 30% dos pacientes pediátricos portadores da doença renal crônica são também portadores de algum tipo de CAKUT, que desencadearam inicialmente o quadro clínico do paciente (LOMBEL RM, et al, 2022). Sob uma primeira análise, deve-se levar em consideração o fato de que a maioria das crianças com CAKUT são diagnosticadas precocemente em países desenvolvidos, permitindo a elas um tratamento eficaz e imediato.…”

Section: Introductionunclassified

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Impactos das anomalias anatômicas no trato urinário em crianças

Pereira,

Lima,

Caruso

et al. 2023

Acervo Saúde

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Objetivo: Analisar as principais anomalias congênitas do rim e trato urinário em crianças, assim como o impacto dessas afecções, suas formas de apresentação e diagnóstico. Revisão bibliográfica: As anomalias congênitas do rim e trato urinário (Congenital Anomalies of the Kidney and the Urinary Tract - CAKUT) são patologias embrionárias de grande incidência em neonatos e podem corroborar para desfechos desfavoráveis na saúde e desenvolvimento da criança. As CAKUT possuem subtipos de classificação e dentre estas patologias destacam-se: Estenose da Junção Ureteropélvica, Refluxo Vesicoureteral, Válvula de uretra posterior e a Doença Renal Crônica. Considerações finais: As anomalias congênitas do rim e trato urinário possuem prevalência no sexo masculino, em nascidos em baixa idade gestacional e possuintes de baixo peso ao nascer. Outrossim, o risco destas anomalias sofre influência direta do histórico de saúde da mãe, evidenciando o impacto de múltiplos fatores para o surgimento dessas afecções. Além do exposto, estudos evidenciam a discrepância em diagnóstico e suporte a essas patologias de acordo com o desenvolvimento do país, fato que reforça a importância do conhecimento acerca do tema a nível nacional no Brasil.

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Section: Doença Renal Crônicaunclassified

Section: Introductionunclassified

Impactos das anomalias anatômicas no trato urinário em crianças

Pereira,

Lima,

Caruso

et al. 2023

Acervo Saúde

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“…Chronic kidney disease (CKD) will eventually develop into end-stage renal disease, with a morbidity of 10%, and is a global public health problem [ 1 ]. The epidemiology of CKD in children is 7–11.4/million people (2018), and the main cause is the kidney and urinary tract [ 2 ]. Long-term dialysis will seriously affect the growth and physical and mental health of children with uremia.…”

Section: Introductionmentioning

confidence: 99%

CCR7 and CD48 as Predicted Targets in Acute Rejection Related to M1 Macrophage after Pediatric Kidney Transplantation

Zhang,

Pei,

et al. 2024

Journal of Immunology Research

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Background. Kidney transplantation (KT) is the best treatment for end‐stage renal disease. Although long and short‐term survival rates for the graft have improved significantly with the development of immunosuppressants, acute rejection (AR) remains a major risk factor attacking the graft and patients. The innate immune response plays an important role in rejection. Therefore, our objective is to determine the biomarkers of congenital immunity associated with AR after KT and provide support for future research. Materials and Methods. A differential expression genes (DEGs) analysis was performed based on the dataset GSE174020 from the NCBI gene Expression Synthesis Database (GEO) and then combined with the GSE5099 M1 macrophage‐related gene identified in the Molecular Signatures Database. We then identified genes in DEGs associated with M1 macrophages defined as DEM1Gs and performed gene ontology (GO) and Kyoto Encyclopedia of Genomes (KEGG) enrichment analysis. Cibersort was used to analyze the immune cell infiltration during AR. At the same time, we used the protein–protein interaction (PPI) network and Cytoscape software to determine the key genes. Dataset, GSE14328 derived from pediatric patients, GSE138043 and GSE9493 derived from adult patients, were used to verify Hub genes. Additional verification was the rat KT model, which was used to perform HE staining, immunohistochemical staining, and Western Blot. Hub genes were searched in the HPA database to confirm their expression. Finally, we construct the interaction network of transcription factor (TF)‐Hub genes and miRNA‐Hub genes. Results. Compared to the normal group, 366 genes were upregulated, and 423 genes were downregulated in the AR group. Then, 106 genes related to M1 macrophages were found among these genes. GO and KEGG enrichment analysis showed that these genes are mainly involved in cytokine binding, antigen binding, NK cell‐mediated cytotoxicity, activation of immune receptors and immune response, and activation of the inflammatory NF‐κB signaling pathway. Two Hub genes, namely CCR7 and CD48, were identified by PPI and Cytoscape analysis. They have been verified in external validation sets, originated from both pediatric patients and adult patients, and animal experiments. In the HPA database, CCR7 and CD48 are mainly expressed in T cells, B cells, macrophages, and tissues where these immune cells are distributed. In addition to immunoinfiltration, CD4+T, CD8+T, NK cells, NKT cells, and monocytes increased significantly in the AR group, which was highly consistent with the results of Hub gene screening. Finally, we predicted that 19 TFs and 32 miRNAs might interact with the Hub gene. Conclusions. Through a comprehensive bioinformatic analysis, our findings may provide predictive and therapeutic targets for AR after KT.

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“…Infections of the urethra, bladder, ureters, and kidneys are a major cause of disease in babies, older men and and women of all ages ( Seifu and Gebissa, 2018) . They can lead to serious problems like frequent infections, pelvic and kidney infections that cause sepsis, and kidney damage in young children (Lombel et al, 2022) . When a pregnant woman has a urinary tract infection, it can cause the baby to come early ( Ghouri et al,2019) .…”

Section: Introductionmentioning

confidence: 99%

BACTERIOLOGICAL STUDY OF COAGULASE-NEGATIVE Staphylococcus spp ISOLATED FROM URINARY TRACT INFECTION AND THEIR RESISTANCE TO ANTIBIOTICS

2022

pnr

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From the rare species that cause urinary tract infections, seven different types of coagulation-negative Staphylococcus bacteria were isolated (9.82%) Staphylococcus epidermidis (8.9%) Staphelococcus haemolyticus, (3%) Staphylococcus xylosus (0.89%) for each bacteria Staphylococcus auricularis, Staphylococcus simulans, Staphylococcus hominis, and Staphylococcus lugduensis, as all isolates were 100% producers of biofilms by tube method and (40%) of Congo Red by Staphelococcus. haemolyticus, while the rest of the species were not producers by the Congo Red method and all isolates were fully resistant to the antibiotics. Amoxicillin/Clavulanic Acid, Oxacillin, Cefotaxim, Cefepime, Levofloxacin, and in a high percentage of cases highly sensitivite to the antibiotics Rifampcin and Amikacin.

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Urologic Considerations in Pediatric Chronic Kidney Disease

Cited by 16 publications

References 77 publications

Impactos das anomalias anatômicas no trato urinário em crianças

Impactos das anomalias anatômicas no trato urinário em crianças

CCR7 and CD48 as Predicted Targets in Acute Rejection Related to M1 Macrophage after Pediatric Kidney Transplantation

BACTERIOLOGICAL STUDY OF COAGULASE-NEGATIVE Staphylococcus spp ISOLATED FROM URINARY TRACT INFECTION AND THEIR RESISTANCE TO ANTIBIOTICS

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