Urologic Manifestations of Chronic Granulomatous Disease of Infancy

Abstract

Chronic granulomatous disease of infancy is a rare hereditary disease that may have urologic manifestations. We describe 2 brothers who had intense cystitis and typical x-ray findings characteristic of this disease. The etiology, incidence and treatment of chronic granulomatous disease of infancy are discussed.

Chronic Granulomatous Disease Masquerading as a Bladder Tumor: A Potential Source of Diagnostic Error

“…Infection, instrumentation or surgery is believed to trigger inflammation leading to granuloma formation, which may result in a variety of urological complications [2], Involvement of the bladder wall with granuloma and diffuse cellular infiltration can pro duce irritative voiding symptoms and occasional urethral or bladder outlet obstruction [7], Although granuloma formation deep in the bladder wall cannot be excluded by mucosal biopsies, granulomas were not a prominent feature in the biopsies obtained from our patient (possibly due to the consequent prophylaxis with antibiot ics).…”

Granulomatous cystitis in chronic granulomatous disease: ultrasound diagnosis

“…Multiple organ systems may be involved, including the skin, gastrointestinal tract, respiratory tract, lymph nodes, liver, spleen, and bones. There are few reports of genitourinary tract involvement [2][3][4][5][6].…”

“…Ultrasound will be helpful in follow up of this child to exclude development of ureteral obstruction or granulomatous nephritis. Ultrasound examination of the bladder should be performed in all children with CGD and cystitis since granulomatous cystitis may be an indication for long-term antibiotic or steroid therapy [3, 61. suprapubic mass [2][3][4][5][6]. Cystography usually shows a low volume, spastic bladder often with vesicoureteral reflux.…”

“…Biopsy specimens reveal intense inflammation with granulomatous reaction [3]. Therapy is difficult and includes antibiotics and steroids [3,4,6].…”