Uropathogenic Escherichia coli in Mexico, an Overview of Virulence and Resistance Determinants: Systematic Review and Meta-analysis

Chitosan-Coated Silver Nanoparticles Inhibit Adherence and Biofilm Formation of Uropathogenic Escherichia coli

“…Our MIC values are even lower than those established by the Clinical Laboratory Standard Institute (CLSI, 2023) for some first-choice antibiotics for the treatment of UTI, such as fosfomycin (≤64 μg/mL) and nitrofurantoin (≤32 μg/mL), and are comparable with other first-choice antibiotics, considering that most of the strains evaluated are MDR. Fosfomycin and nitrofurantoin are two of the antibiotics recommended in the treatment of UTI, and so far, in Mexico, they represent two of the most efficient therapeutic options . In this sense, we determined the MIC of fosfomycin for the 40 clinical isolates (Table S2), and we observed that eight were considered as nonsusceptible (resistant or with intermediate resistance) with MIC values of 128–256 μg/mL, that represent 10 times the amount of SH-Cs-AgNPs evaluated in this work, thus reinforcing our conclusion that nanoparticles could represent an important therapeutic option in the future.…”

“…Fosfomycin and nitrofurantoin are two of the antibiotics recommended in the treatment of UTI, and so far, in Mexico, they represent two of the most efficient therapeutic options. 3 In this sense, we determined the MIC of fosfomycin for the 40 clinical isolates In accordance with these results, 10 strains were selected, based on the obtained MIC values and their virulence characteristics, such as adherence, biofilm formation, and antibiotic resistance, as bacterial models to evaluate the potential of SH-Cs-AgNPs to inhibit the survival and pathogenic mechanisms of these bacteria. The MIC of SH-Cs-AgNPs against the selected isolates, except for UPEC 29, was 12.5 μg/mL.…”

“…Furthermore, there is a growing prevalence of multidrug-resistant (MDR) strains including carbapenemaseproducing E. coli, which severely limit the range of available therapeutic options in the standard-of-care treatment protocol. 2,3 For most bacterial pathogens, adherence to epithelial cells is the first step to infection and colonization. 4 UPEC can adhere to the urinary tract epithelial cells via multiple receptors, for example, the mannosylated residues of uroplakine-1a and α3β1 integrins which are present in uroepithelial cells facing the lumen, which are recognized by UPEC's fimbrial adhesin FimH, promoting colonization, invasion, and internalization, forming intracellular bacterial communities (IBCs), which are responsible for persistent infections, immune system evasion, and poor response to treatment.…”

“…Furthermore, there is a growing prevalence of multidrug-resistant (MDR) strains including carbapenemase-producing E. coli, which severely limit the range of available therapeutic options in the standard-of-care treatment protocol. , …”

Synthesis of Fe-doped ZnO/biochar nanocomposites for acid orange 7 photodegradation and antibacterial activity under visible light region

“…Escherichia coli is a pathogenic microorganism that can cause waterborne diseases such as diarrhea, cystitis, and pyelonephritis [3]. Its presence in the aquatic environment can disrupt the ecological balance and pose a threat to human health even at low concentrations [4]. Antibacterial agents are essential tools for treating bacterial infections.…”