Uropepsin Excretion in Gastroduodenal Disease

Cubberley, David A.; Dagradi, Angelo E.; Carne, Herbert O.; Stempien, Stephen J.

doi:10.1016/s0016-5085(55)80066-2

Cited by 17 publications

(1 citation statement)

References 11 publications

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“…However, the same aggravating factors which selectively Slimulate the exocrine limb of pepsinogen or cause a disruption of the cytoprotective mechanism may, under extreme conditions, give rise 10 peptic ulceralion. There being no Page /04 -lIMA: Volume 22,1990 increased chief cell mass, nor a stimulated endocrine limb, the serum as weJ) as (he urinary pepsinogen levels remain within normal Iimits-Menguy et aF' have proposed that stres~ulcers (which may be included in secondary DU) are the result of mucmal energy deficils severe enough to cause cellular n.ecrosis_ Because Ihis mechanism is unrelated 10 hypersecretion. such ulcers obviously do nOI have associated hyperpepsinogenemia nnd also do nOI menifesl increased excretion of uropepsinogen.…”

Section: The Peptic Secrclory Cell Mass Imentioning

confidence: 99%

Elevated Urinary Pepsinogen: A Subclinical Marker of Ulcer Diathesis

Ali¹,

Mahboobunnisa²,

Habibullah³

1990

J Islam Med Assoc

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MaterialS Dnd mel hods Two hundred and seventy-eight patients with DU (242 males and 36 females), ages oelween 15 and 69 years (mean 43 ± 16.41), and 36 male patients with GU, PU. and SU (12 in each catogory) were studied in the Department of Gastroenterology, Osmania General Hospital, Hyderabad. India, The selection of patients was based on endoscopic observations. One hundred age and sex matched healthy individuals without a history of peptic ulcer, dyspepsia or renal disease, served as cant rols. Twenty-four hOur urine samples were collected from patients and controls-An aliquot was used for the estimation of urinary pepsinogen. Urinary pep-pepsinogen is invariably present in l,he urine but group-II pepsinogen is rarely found in the normal urine. This is be.:ause it exiSIS in the circulal ion in a polymeri2.ed form and can nOI be filtered. or it is attached to a~rum protein. J)," This smdy was conducted to detennine the urinary pepsinogen levels in di fferent types of pept ic uleer". such as duodenal ulcer (DU), gastric ulcer (GU). pyloric ulcer (PU) and stomal ulcer (SU). to find OUI the gastric secretory fune/ion by the estimation of urinary pepsi nagen, and to eva luate cleva I etl urinary pepsinogen as a SUbclinical marker Df ulcer diathesis.

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Section: The Peptic Secrclory Cell Mass Imentioning

confidence: 99%

Elevated Urinary Pepsinogen: A Subclinical Marker of Ulcer Diathesis

Ali¹,

Mahboobunnisa²,

Habibullah³

1990

J Islam Med Assoc

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Uropepsin Excretion

Rosenberg¹

1957

AMA Arch Intern Med

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urine has been known for almost a century;Br\l=u"\cke 1 first mentioned it in 1861, Frouin 2 described it in 1904, and Gottlieb3 further added to its understanding in 1924. It remained dormant until 1946, when Farnsworth 4 published a review of the literature, with comments on the absence of this pepsinlike substance in the urine of perniciousanemia patients. The following year, Bucher 5 evaluated the effects of varied diets on this urinary substance, now termed "uropepsin," hereafter referred to as U-P (the end-product of uropepsinogen activation). The last decade has seen a renewed interest in U-P studies, further intensified by the impact of Selye's "Adaptation Syndrome" and the emergence of endocrinology from its early theoretical stage to the maturity of the corticotropin-cortisone era, and strengthened by innumerable practitioners who would spare their patients the discomforts of the stomach tube.Our purpose in this paper is (1) to present our experiences in the study of U-P excretion while covering a kaleidoscope of diseases and derangements, (2) to compare these studies with the results of the many other workers in this fruitful vineyard, and (3) to assess the role of this laboratory test in clinical medicine. Review of the LiteratureWest 8 noted the day-to-day constancy of U-P excretion; this is contradicted by the antithetical findings of Goodman.9 Broh-Kahn " notes close agreement of the day versus night excretion, but West8 finds a slight decrease in excretion in the afternoon and evening. Broh-Kahn 7 found no signif¬ icant changes in LT-P excretion due to volume, specific gravity, or acidity of the urine. A high-protein diet caused an in¬ creased U-P excretion in Bucher's study,5 but Goodman9 found a high-protein diet productive of normal values only. Bucher 5 also noted a decreased excretion by subjects given a high-carbohydrate diet. Several observers "·" found constant excretion pat¬ terns in subjects given normal diets.Bridgwater et al.38 found U-P excretion by males to be 60% greater than by females; decreased excretion was observed in pré¬ adolescents and "adults over 60." U-P and 17-ketosteroid excretion patterns correlated well in young men, according to Garst,10 but rather poorly in older men.Mertenc found decreased excretion in infectious diseases and undernutrition; Tobler 13 noted significant elevations in pa¬ tients after vaginal or abdominal surgery.Both atropine 12 and propantheline (Pro-Banthine) 14 may cause a decrease in U-P excretion; the Rauwolfia drugs41 exert little influence.Numerous observers ».*M2,i«-ii> nave founcl significant increases in U-P excretion in cases of duodenal ulcer. However, some9 have remarked on the significant percentage of patients with duodenal ulcer who excrete normal amounts of U-P. Others i2 report

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The Influence of Various Clinical Disorders and Drugs on Excretion of Uropepsin

Corazza¹,

Myerson²

1957

JAMA

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Uropepsin Excretion in Gastroduodenal Disease

Cited by 17 publications

References 11 publications

Elevated Urinary Pepsinogen: A Subclinical Marker of Ulcer Diathesis

Elevated Urinary Pepsinogen: A Subclinical Marker of Ulcer Diathesis

Uropepsin Excretion

The Influence of Various Clinical Disorders and Drugs on Excretion of Uropepsin

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