Urothelial carcinoma in children: A case series

Marinoni, Federica; Destro, Francesca; Selvaggio, G; Riccipetitoni, Giovanna

doi:10.1016/j.bulcan.2018.03.002

Cited by 9 publications

(9 citation statements)

References 25 publications

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“…Urinary frequency, recurrent cystitis, pyelonephritis, obstruction, abdominal pain, flank pain, fever, hematospermia, nephrolithiasis, and emesis were among the numerous atypical presenting symptoms mentioned in the literature [5]. Detection of bladder mass on a routine ultrasound abdomen and pelvis has also been described [6].…”

Section: Discussionmentioning

confidence: 98%

Urinary bladder tumour in a 10 years old child: A case report on urothelial papilloma

Aggarwal¹,

Hegde²,

Hameed³

et al. 2022

J Clin Images Med Case Rep

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The suspicion and diagnosis of urothelial neoplasm are considered a rare commodity in the pediatric age group presenting with hematuria. A 10 years old patient presented to out-patient department with lower pain abdomen and hematuria for 2 months. Routine examination and ultrasonography, followed by urethrocystoscopy, revealed a solitary intravesical lesion in close approximation to the right ureteric orifice. Patient underwent transurethral resection of the bladder mass with histopathology confirming urothelial papilloma. This benign tumour is extremely rare in childhood with much to decipher of its etiology and further management.

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Section: Discussionmentioning

confidence: 98%

Urinary bladder tumour in a 10 years old child: A case report on urothelial papilloma

Aggarwal¹,

Hegde²,

Hameed³

et al. 2022

J Clin Images Med Case Rep

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“…The same proposal was done in 2016 by Polat et al [15]. However, Marinoni et al preferred, as a follow-up, cystoscopies after 3 and 12 months together with USG [16]. According to this latter study, the USG surveillance should be continued for 5 years and the cystoscopy should be proposed, after the first year, only if the ultrasounds came back positive for recurrence.…”

Section: Discussionmentioning

confidence: 98%

“…According to this latter study, the USG surveillance should be continued for 5 years and the cystoscopy should be proposed, after the first year, only if the ultrasounds came back positive for recurrence. In all the previous studies known to us, it is shown that urine cytology is unnecessary since the pediatric bladder lesions are mostly benign and that USG is a gold standard to detect recurrent lesions due to its high sensitivity [14][15][16].…”

Section: Discussionmentioning

confidence: 99%

Transurethral en bloc resection of non-muscle invasive bladder cancer with holmium:YAG laser in pediatric patients: cases series and review of literatures

et al. 2020

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Introduction Urothelial bladder carcinoma frequently occurs in adults over 60 years of age; yet it affects only 0.1-0.4% of patients before the first 2 decades of life. We present two cases of transitional cell carcinoma in two young patients treated with holmium:YAG laser to demonstrate the effectiveness of this technique in pediatrics. Cases and methods Case study 1 During a routine abdomen ultrasound, a 14-year-old female showed a endoluminal formation about 10 × 6 × 10 mm of size, in the left paramedian site. There was an absence of meaningful vascular signs during color-Doppler. Physical examination and laboratory exams were all normal. Case study 2 A 12-year-old female presented with acute macroscopic haematuria. No other symptoms were associated. Bladder ultrasound revealed an irregular 15 mm intravesical endophytic lesion in the posterior-superior area. In both cases, treatment commenced with an en bloc enucleation. For the resections, a 272 µm holmium:YAG fiber laser was used through the 12 Ch cystoscopy working channel with an energy of 0.8-1 J/pulse and a frequency of 8-10 Hz. Results There was no haematuria after the procedure and the transurethral catheter remained for 12 h. The histological diagnosis was papillary urothelial neoplasm of low malignant potential. Cystoscopy was performed 3 and 9 months after the surgery and an ultrasound every 6 months, which all came back normal. The follow-up continued for each patient with a cystoscopy once a year, according to EAU guidelines. Conclusion Based on the findings, holmium:YAG laser is a good alternative to treat superficial transitional cell carcinoma in pediatric patients.Keywords Pediatric bladder cancer · Holmium:YAG laser · Transurethral en bloc resection · PUNLMP · Transitional cell carcinoma Abbreviations USG Ultrasonography SOL Space-occupying lesion PUNLMP Papillary urothelial neoplasm of low malignant potential TCC Transitional cell carcinoma

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“…A wide range of other unusual presenting symptoms were reported in literature [urinary frequency, recurrent cystitis, pyelonephritis, obstruction, abdominal pain, flank pain, fever, hematospermia, nephrolithiasis, and emesis (8)]. Incidental bladder mass finding has also been describe (9).…”

Section: Discussionmentioning

confidence: 99%

“…In pediatrics, one study reports a 16-years old boy who was a steady smoker (5). A case series revealed three cases of urothelial carcinoma in children with a history of environmental exposure to amines (9).…”

Section: Discussionmentioning

confidence: 99%

Bladder Urothelial Carcinoma in a Child: Case Report and Review of Literature

et al. 2019

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Bladder urothelial carcinoma (UC) it is the fifth most prevalent carcinoma in humans, nevertheless in children and young adults it's very rare. It usually occurs in older adults. Literature on UC in pediatric population is limited and important information (risk factors, follow-up protocols, etc.) are poorly defined. We present an 11-year-old boy with a painful macroscopic hematuria. Ultrasound revealed a heterogeneous intravesical mass without extravesical extension, which was confirmed by computed tomography (CT) and magnetic resonance imaging (MRI). The first biopsy was compatible with urothelial papilloma. After 1 year, he returned with a bigger mass. Transurethral resection of the bladder (TURB) was performed and immunohistochemistry showed low-grade papillary UC with a high-grade component, with tumor free margin. Tumor had mutations in the BRAF and KRAS genes. Two and a half years after the resection the patient has no recurrence. Less than 1% of bladder UC occur in the first two decades of life. Gross hematuria is a common symptom. Ultrasound is generally the first diagnostic tool. MRI is also helpful, but cystoscopy allows definitive diagnosis. Transurethral resection of the bladder (TURB) is the standard treatment, with good results and low recurrence rate, and it was the treatment of choice for our patient, that remains free of disease. The BRAF and KRAS gene mutations were never described before in pediatric UC. There are only few cases in literature of pediatric UC that present a tumor genetic profile; therefore, our case report adds more information to this very rare disease in children.

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Urothelial carcinoma in children: A case series

Cited by 9 publications

References 25 publications

Urinary bladder tumour in a 10 years old child: A case report on urothelial papilloma

Urinary bladder tumour in a 10 years old child: A case report on urothelial papilloma

Transurethral en bloc resection of non-muscle invasive bladder cancer with holmium:YAG laser in pediatric patients: cases series and review of literatures

Bladder Urothelial Carcinoma in a Child: Case Report and Review of Literature

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