Urothelial carcinoma of the allograft kidney developed in a renal transplant patient

Gökçe, Mehmet İlker; Kocaay, Akın Fırat; Aktürk, Serkan; Tüzüner, Acar

doi:10.5152/tud.2016.97415

Cited by 5 publications

(3 citation statements)

References 13 publications

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“…Following renal transplant, kidney cancer almost exclusively occurs in native kidneys with papillary RCC as the most common type 9 . However, donor-derived malignancies are rarely reported 6,7 . Our case is a rare donor-derived UC in the graft kidney with a few very interesting facts.…”

Section: Discussionmentioning

confidence: 99%

“…These patients also have a 3-fold increased risk of developing urothelial carcinoma (UC) in the native bladder, which is associated with BK polyomavirus. However, donor-derived UC is rarely reported 6,7 . We herein report a high grade papillary urothelial carcinoma of the graft kidney, involving the graft ureter and native urinary bladder, invading one left obturator lymph node, and sparing the two native kidneys and ureters.…”

Section: Introductionmentioning

confidence: 99%

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Urothelial Carcinoma of the Graft Kidney With Molecular Analyses: A Rare Case Report

Chen

Haines

Lam

et al. 2021

Preprint

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BACKGROUNDMalignancy after transplantation is a leading cause of death in kidney transplant recipients. However, donor-derived malignancies are rarely reported. We herein report a high grade papillary urothelial carcinoma of the graft kidney, involving the graft ureter and native urinary bladder, invading one left obturator lymph node, and sparing the two native kidneys and ureters.CASE PRESENTATION62-year-old female with history of kidney transplantation more than 30 years ago, who presented with urinary tract infection, acute renal failure, and hydronephrosis of the transplant kidney. Anterograde nephrostogram showed a large filling defect in the lower pole of the transplant kidney and a filling defect in the proximal 3-4 cm of ureter. Biopsy taken from the renal pelvic mass showed a high grade urothelial carcinoma. She underwent hysterectomy, bilateral salpingo-oophorectomy, nephrectomy of native kidneys and transplant kidney, cystectomy and bilateral pelvic lymph node dissections. Histology showed a high grade papillary urothelial carcinoma of the graft kidney, involving the graft ureter, native urinary bladder and one left obturator lymph node and sparing the two native kidneys and ureters. Short tandem repeat (STR) analysis confirmed the tumor was of donor origin. The next-generation sequencing identified amplification of TERT and loss of CDKN2A/CDKN2B in the primary tumor.CONCLUSIONWhile it is known that transplant recipients have an increased risk of urothelial carcinoma compared to the general population, the lack of the well-documented risk factors, such as older age at transplantation, BK polyomavirus infection, and prolonged post-transplantation history and dissemination of the tumor in this case shed light on the de novo tumorigenesis of the graft kidney within the host microenvironment. Amplification of Telomerase reverse transcriptase (TERT) and loss of cyclin dependent kinase inhibitor 2A/2B (CDKN2A/CDKN2B) detected in the tumor by next gene sequencing suggests that they may play an important role in this case.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Urothelial Carcinoma of the Graft Kidney With Molecular Analyses: A Rare Case Report

Chen

Haines

Lam

et al. 2021

Preprint

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“…The previous reported cases had documented death in 7/36. 10,28,30,31 No follow-up information was also available for further 7/36 3,34,35 and for the remnant cases, there is often a limited follow-up. Subsequent successful transplantation has been reported in selected cases after an extended disease-free interval 33 ; whilst we are unable to comment based on the short duration of follow-up, patients could potentially be considered for further transplantation after an appropriate disease-free period, generally 1 year.…”

Section: Discussionmentioning

confidence: 99%

Urothelial carcinoma arising from the transplanted kidney: A single‐center experience and literature review

Bellini

Gopal

Hill

et al. 2019

Clinical Transplantation

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Urothelial carcinoma (UC) is a malignancy predominantly arising in the bladder. Upper tract UC (UUC) is uncommon, accounting only for 5-10% of the cases. High incidence of neoplasms is associated with immunosuppressive therapy; thus, UCs of the transplanted grafts often lead to a more aggressive treatment, in order to withdraw completely the immunosuppression. It significantly affects the patient quality of life, meaning return to dialysis, along with the worse life expectancy. We present our single-institution experience of this rare malignancy in two mid-age kidney transplant recipients, with UCs successfully treated with radical nephroureterectomy: G3 pT3 N0 + G3 pT1 N0 in the first patient and G3 pT2 N0 in the second one. We also review the previous literature focusing on stage of presentation and treatment for the affected kidney transplant patients. K E Y W O R D Sgraft nephrectomy, immunosuppression, kidney transplant, malignancy, urothelial carcinoma

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Diagnosis and Management of a De Novo Urothelial Carcinoma in a Kidney Allograft: A Case Report

Farkas

Török

Kovács

et al. 2019

Transplantation Proceedings

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Urothelial carcinoma of the allograft kidney developed in a renal transplant patient

Cited by 5 publications

References 13 publications

Urothelial Carcinoma of the Graft Kidney With Molecular Analyses: A Rare Case Report

Urothelial Carcinoma of the Graft Kidney With Molecular Analyses: A Rare Case Report

Urothelial carcinoma arising from the transplanted kidney: A single‐center experience and literature review

Diagnosis and Management of a De Novo Urothelial Carcinoma in a Kidney Allograft: A Case Report

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