Urothelial Carcinoma With Villoglandular Differentiation

Mitra, Suvradeep; Sundaram, Archana; Gupta, Kirti; Devana, Sudheer Kumar

doi:10.1177/1066896915621387

Cited by 4 publications

(9 citation statements)

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“…Membranous positivity was also further subcategorized as complete or incomplete. The clinicopathological features of one of the cases had been reported earlier (3). All the samples were TURBT (Transurethral resection of bladder tumour) specimens and the radical cystectomy specimen of one of the cases (previously reported case) was also obtained.…”

Section: Casesmentioning

confidence: 99%

“…Histomorphologically, this entity shows a divergent differentiation towards gastrointestinal epithelium resembling an intestinal adenomatous polyp coexisting with and intricately admixed with urothelial carcinoma. Most of the cases of UCVGD are reported to be associated with a high-grade component of urothelial carcinoma and are found to show lamina propria and/or detrusor muscle invasion, implying a poorer prognosis (1,(3)(4)(5). Villous adenoma is also a rare preneoplastic condition in the genitourinary tract and presumably arises from the cloacogenic remnant.…”

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confidence: 99%

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Urothelial tumors with villous morphology: Histomorphology and role of immunohistochemistry in diagnosis

Mitra

Chatterjee

Das

et al. 2018

APMIS

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Villous adenoma and urothelial carcinoma with villoglandular differentiation (UCVGD) are rare urothelial tumours showing villous morphology, the former being a preneoplastic entity and the latter being a malignant one. The detailed immunohistochemistry of these entities is previously not described in the literature. Moreover, a limited biopsy sample of UCVGD or a villous adenoma with or without adenocarcinoma may be difficult to distinguish on the basis of the histomorphology alone. An immunohistochemical panel comprising of GATA3, p63, β-catenin, CK7 and CK20 was performed on five cases of UCVGD and three cases of villous adenoma with the aim of studying the expression of the proteins thereby aiding in the diagnosis of these entities in a limited surgical pathology specimen. The mean age of UCVGD was 66.8 years and all the patients were male. All the cases of UCVGD were associated with high grade papillary urothelial carcinoma with lamina propria invasion. The immunohistochemical panel showed strong nuclear GATA3 expression in the urothelial component of UCVGD. Interestingly, the high grade and the low grade villoglandular components of UCVGD also expressed GATA3 (nuclear) with a progressive loss of expression from the high grade to the low grade component. The villous adenomas showed negativity or aberrant cytoplasmic positivity for GATA3. The β-catenin showed a gradual loss of membranous expression from villous adenoma to low grade and high grade villoglandular components of UCVGD with a patchy membranous expression in the urothelial component of the UCVGD. p63 showed strong nuclear positivity in the urothelial component and uniform negativity in the villous adenoma and villoglandular component of UCVGD irrespective of its grade, thereby distinguishing the villoglandular component from the urothelial component. The urothelial component of UCVGD showed strong membranous CK7 expression and was higher than the CK20 expression in the urothelial component. In contrast, CK20 expression was higher in villous adenoma as compared to CK7. There was no difference in the expression of CK7 and CK20 in the villoglandular components and low grade and high grade villoglandular areas. The above-mentioned immunohistochemical pattern may help to distinguish the UCVGD from the villous adenoma.

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Section: Casesmentioning

confidence: 99%

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confidence: 99%

Urothelial tumors with villous morphology: Histomorphology and role of immunohistochemistry in diagnosis

Mitra

Chatterjee

Das

et al. 2018

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“…Till date, histopathology of only a few cases have been described in the literature. [1][2][3][4] To the best of our knowledge, the cytological features that could allow the diagnosis of this entity have not been described.…”

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“…1 This entity has recently been described in a case series and two case reports. [2][3][4] Histopathology shows an admixture of papillae with finger like filiform processes, the papillae being lined by the transitional lining epithelium whereas the filiform villi are lined by columnar epithelium simulating colonic epithelium. In addition, the surface also shows cribriform and glandular architecture.…”

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confidence: 99%

“…Despite its rarity, it is important to identify this entity as most of the cases showed associated high grade urothelial morphology and lamina propria or detrusor muscle invasion, as mentioned in the previous case reports and case series. [2][3][4] Urothelial carcinoma with squamous or glandular differentiation usually present as a higher stage explaining their aggressive behaviour. 5 All our cases also showed high grade morphology and detrusor muscle invasion supporting this view.…”

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Urine cytology of urothelial carcinoma with villoglandular differentiation

Mitra

Chatterjee

Gupta

et al. 2016

Diagnostic Cytopathology

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