Urothelial Tumors of the Urinary Bladder in Manipur: A Histopathological Perspective

Abstract

The study included 26 cases of transitional cell tumors of urinary bladder. The male to female ratio was 1.5: 1 and the ages ranged from 38 years to 73 years (medians of 60 and 64 years, respectively). Of the total, 14 (53.9%) cases were low grade, 9 (34.6%) were high grade, 2 (7.7%) were papillomas and 1 (3.9%) was a papillary urothelial neoplasm of low malignant potential (PUNLMP). Pathological staging showed that 14 (53.9%) of the cases were stage PTa, four (15.4%) PT1, and eight (30.9%) PT2. Some 18.2% of low grade tumors and 75% of high grade tumors were invasive to the detrusor muscle layer. Conclusion: Bladder cancer is an uncommon disease, transitional tumors being the only histological type observed. It was more common in males than females, with peak incidence in seventh decade. Most of the tumors were non-invasive (PTa) and invasion to the detrusor muscle layer was seen in more than half of the high grade tumors. There is a definite correlation between advancing tumor grade and muscle invasion.

A gamut of Histopathological Lesions of Carcinoma of Urinary Bladder- A study of 43 Cases

“…[6] 2004-2005 106 59.4 Zhang et al [7] 2006-2010 658 61.9 Gupta et al [8] 2001-2008 561 60.2 Laishram et al [9] 2001-2010 26 62 Biswas et al [10] 2007-2009 88 65 Present Study 2012-2014 45 59.3 As compared to other study series the present study also showed relatively higher male incidence. The gender incidence in our study was more in males than females with a sex ratio of 3.1:1 which is lower than the most of the studies [7][8] [10] but higher than the study done by Laishram et al [9] [7] 2006-2010 548 110 5:1 Gupta et al [8] 2001-2008 431 50 8.6:1 Laishram et al [9] 2001-2010 15 11 1.5:1 Biswas et al [10] 2007-2009 76 12 6.3:1 Present Study 2012-2014 34 11 3.1:1 In the present study we found that haematuria(80%) was the most common presenting symptom. Other symptoms abdominal pain (9%), increased frequency (5%) and urinary incontinence, vaginal bleeding and amenorrhea (2% each) were noted.…”

A Clinicopathological Study of Various Lesions Encountered in Cystoscopic Bladder Biopsies

“…Therefore, the invasion cannot be assessed. In his study, Laishram et al (5) found muscle invasion in 42.1% cases. (5) Our study showed 25% cases of invasive urothelial carcinoma.…”

“…In his study, Laishram et al (5) found muscle invasion in 42.1% cases. (5) Our study showed 25% cases of invasive urothelial carcinoma. Hence, inclusion of detrusor muscle in the cystoscopic biopsy is very important.…”

“…(3,4,6,18) Very rarely these lowgrade tumour would also recur if there was an evidence of invasion. (1,2,4,5) Urothelial neoplasm which show papillary fronds of urothelium, which shows a significantly disordered architectural and cytologic pattern with moderate cytologic atypia. (6,7,8) It contains cells that are dyscohesive with large hyperchromatic nuclei, high degrees of anaplasia and atypical mitotic figures.…”

“…(7) The most common sign is gross and microscopic haematuria. (1,2,5,6) Cystoscopy is the primary diagnostic tool.…”