Urothelial tumors of upper tract following treatment of primary bladder transitional cell carcinoma

Schwartz, Carly; Bekirov, Huseyin; Melman, Arnold

doi:10.1016/0090-4295(92)90404-k

Cited by 53 publications

(13 citation statements)

References 9 publications

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“…Herr and Whitmore 12 found that 19 of 66 patients (28.8%) with multifocal flat carcinoma in situ (CIS) of the bladder had evidence of distal ureteral CIS between 13 and 30 months (mean 15 months) after bacillus Calmette‐Guérin treatment. Schwartz et al 2 . studied 638 patients with superficial TCC of urinary bladder.…”

Section: Discussionmentioning

confidence: 99%

“…Transitional cell carcinoma (TCC) of the urinary bladder is characterized by multifocality and high recurrence rate. Although it has been reported that subsequent upper urinary tract tumors occur in 0–3.1% of patients with superficial bladder tumor, 1,2 little is known about the effect of the location, stage of primary bladder tumor on the incidence of upper tract recurrence.…”

Section: Introductionmentioning

confidence: 99%

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Superficial transitional cell carcinoma of the ureteral orifice: Higher risk of developing subsequent upper urinary tract tumors

et al. 2006

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Aim : Reports specifically addressing transitional cell carcinoma (TCC) of the ureteral orifice are scarce. This paper presents our experiences of such tumors, including the characteristics of the disease and the incidence of subsequent upper urinary tract recurrence. Methods : This study included 572 new cases of TCC of the urinary bladder diagnosed in our institute during a period of 5 years. Thirty-one (5.4%) patients had superficial tumors involving ureteral orifices. All 31 patients underwent transurethral resection of the bladder tumors, including the involved ureteral orifices. After the surgery, patients received regular follow up with cystourethroscopy, urine cytology and periodic intravenous pyelography (IVP). Ureterorenoscopy was performed in cases of suspicious IVP or urine cytology findings. Results : Thirty-one patients with superficial tumors involving the ureteral orifice were followed up for 5-8 years or until death. The pathological stage was Ta in 16 cases and T1 in 15 cases. Bladder tumor recurrence was noted in three (18.8%) of the pTa patients and in seven (46.7%) of the pT1 patients. Subsequent upper urinary tract tumors developed in four (12.9%) patients between 33 and 67 months (mean: 33.5) after the first transurethral resection. All four cases of upper tract recurrence had pT1 primary bladder tumor, which recurred for 1-3 times (mean 1.8) before upper tract recurrence. None of these patients had ureteral stenting after bladder tumor resection. Three of four patients with upper tract recurrence had single lower ureteral tumor, while the remaining one patient had multiple tumors. Patients with subsequent upper urinary tract tumors underwent nephroureterectomy and bladder cuff excision. One died of the disease; the other three cases were free of the disease after the therapy. Conclusions : Patients with primary superficial bladder transitional cell carcinoma involving the ureteral orifice have a higher risk of developing subsequent upper urinary tract tumors, particularly for pT1 primary bladder tumors. Frequent and close follow up is recommended.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Superficial transitional cell carcinoma of the ureteral orifice: Higher risk of developing subsequent upper urinary tract tumors

et al. 2006

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“…[5] However, if one selects only the high-risk NMIBC patients who received intravesical BCG, the incidence rate of subsequent UUT-TCC increases to 20-25%. [168101314] Table 1 lists published studies that focus on monitoring the UUT of bladder cancer patients.…”

Section: Evidence Reviewmentioning

confidence: 99%

Monitoring of the upper urinary tract in patients with bladder cancer

Ayyathurai¹,

Soloway²

2011

Indian J Urol

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Upper urinary tract (UUT) transitional cell carcinoma (TCC) is relatively rare tumor. Approximately 0.7-4% of patients with primary bladder cancer develops UUT-TCC. The symptoms related to an UUT-TCC often occur with an advanced stage which leads one to emphasize a surveillance strategy to monitor the UUT to allow for an earlier diagnosis. Although the risk of UUT-TCC after bladder cancer is well established, there is a paucity of recommendations suggesting the optimal method and frequency of monitoring the UUT and there is no consensus among them. This article reviews the recommendations on monitoring the UUT in patients with bladder cancer.

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“…Transitional cell carcinoma (TCC) of the urinary tract has the characteristics of multifocal occurrences. [1][2][3] The mechanism leading to the multifocality of TCC has been attributed to the seeding of exfoliated tumor cells or to a general sensitivity of the entire urothelium to carcinogenic stimuli. 4 However, there is still no direct pathological evidence showing that the natural seeding of tumor cells is a real phenomenon.…”

Section: Introductionmentioning

confidence: 99%

Possibility of spontaneous seeding of transitional cell carcinoma of the ureter in renal tubules: Another mechanism of transitional cell carcinoma dissemination

Fong¹,

Chen

Hsieh³

et al. 2006

Int J of Urology

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Cancer cell seeding inside the urinary tract always has been considered one possible mechanism of the multicentric origin of transitional cell carcinoma (TCC). However, there is still no direct clinical evidence to prove that the natural seeding of TCC is a real event. To our knowledge, we report the first case of spontaneous seeding of TCC of the ureter in the renal tubules of a hydronephrotic kidney. The TCC nature of the intratubular tumor cells has been confirmed by the morphological appearance of them after hematoxylin and eosin staining and positive p53 immunohistochemical staining.

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Urothelial tumors of upper tract following treatment of primary bladder transitional cell carcinoma

Cited by 53 publications

References 9 publications

Superficial transitional cell carcinoma of the ureteral orifice: Higher risk of developing subsequent upper urinary tract tumors

Superficial transitional cell carcinoma of the ureteral orifice: Higher risk of developing subsequent upper urinary tract tumors

Monitoring of the upper urinary tract in patients with bladder cancer

Possibility of spontaneous seeding of transitional cell carcinoma of the ureter in renal tubules: Another mechanism of transitional cell carcinoma dissemination

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