Ursodeoxycholic acid alleviates cholestasis-induced histophysiological alterations in the male reproductive system of bile duct-ligated rats

Testicular immunohistochemical and Ultrastructural changes associated with chronic cholestasis in rats: Effect of ursodeoxycholic acid

“…A previous work has shown that UDCA could ameliorate the reproductive functional and histological alterations induced by chronic cholestasis and restore the sperm parameters to control values [22]. The present study revealed that the administration of UDCA improved the testicular morphology and reversed cholestasis-induced immunohistochemical and ultrastructural changes.…”

“…In a previous study, we have shown that UDCA could ameliorate the reproductive structural and functional alterations induced by chronic cholestasis and restore the sperm parameters to control values [22]. The present study further investigates the usefulness of UDCA in ameliorating the testicular immunohistochemical and ultrastructural alterations induced by chronic cholestasis and restoring the normal spermatogenic process.…”

Effect of α-Chlorohydrin water-bait on the fertility of captive males of the Egyptian fruit-bat (Rousettus aegyptiacus) and the proper time for controlling its free-ranging populations in Egypt

“…6H2 O, 0.36 mM NaH2PO4. 2H2O, 5.56 mM glucose, 25 mM NaHCO4, 1.80 mM CaCl2, 100 units penicillin and 4 mg/ml BSA) at 35°C for later determination of sperm characteristics (Saad and Mahmoud, 2014).…”

“…Sperm were counted in the four corner-squares as well as in the central square. The data were expressed as the number of sperm/ml (Saad and Mahmoud, 2014).…”

Nuclear Receptor Metabolism of Bile Acids and Xenobiotics: A Coordinated Detoxification System with Impact on Health and Diseases

“…Pharmalogical modulations of BA transporters and their regulatory NRs have significantly contributed to the development of novel treatment strategies for several hepatobiliary disorders, including cholestasis, gallstones, and fatty liver diseases. In addition, clinical and experimental data indicate that enhanced bile flow by the secondary BA UCDA might produce other beneficial effects by preventing hypogonadism in patients with long-standing cholestasis and alleviating reproductive system alterations, as shown in male rat with chronic cholestasis induced by permanent common bile duct ligation [ 148 , 149 ]. These positive effects of UCDA suggest that unbalanced BA levels might be deleterious to both endocrine and exocrine functions of the testes, and have warranted numerous studies that have highlighted a significant link between BA metabolism and male fertility disorders.…”