Ursodeoxycholic Acid and Atorvastatin in the Treatment of Nonalcoholic Steatohepatitis

Kıyıcı, Murat; Gülten, Macit; Gürel, Selım; Nak, Selim Giray; Dolar, Enver; Savcı, Gürsel; Adım, Şaduman Balaban; Yerci, Ömer; Memık, Faruk

doi:10.1155/2003/857869

Cited by 181 publications

(126 citation statements)

References 12 publications

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“…Severe liver damage and liver failure are very rare (119). Paradoxically, statins are currently used to treat NAFLD (120,121), and recent studies suggest that statins are hepatoprotective in patients with HCV (122).…”

Section: Pharmacologic Therapymentioning

confidence: 99%

“…While many studies have shown improvement in steatosis, there are neither long-term studies to determine whether they alter the natural history of the disease nor studies to indicate whether relapse occurs after treatment withdrawal. Gemfibrozil (145), vitamin E (146), metformin (88 -91), betaine (147), pioglitazone (92)(93)(94)(95)(96), rosiglitazone (97), atorvastatin (120,121), losartan (128), orlistat (148), and pentoxifylline (149) have all been tried and have all been shown in small trials to improve liver enzymes. Modest histologic improvement over 6 -12 months is seen with some of the agents.…”

Section: Treatment Of Nafldmentioning

confidence: 99%

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Spectrum of Liver Disease in Type 2 Diabetes and Management of Patients With Diabetes and Liver Disease

et al. 2007

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Section: Pharmacologic Therapymentioning

confidence: 99%

Section: Treatment Of Nafldmentioning

confidence: 99%

Spectrum of Liver Disease in Type 2 Diabetes and Management of Patients With Diabetes and Liver Disease

et al. 2007

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“…Kiyici et al (16) carried out a study evaluating atorvastatin in patients with NASH, and observed a significant reduction in the aminotransferases levels. In ammatory activity…”

Section: Nash As Well As May Test the Results Of Several Drugs In Itsmentioning

confidence: 99%

The vitamin E reduces liver lipoperoxidation and fibrosis in a model of nonalcoholic steatohepatitis

Zamin

Mattos

et al. 2010

Arq. Gastroenterol.

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-Context -No effective treatment is available for nonalcoholic steatohepatitis in nowadays. Objectives -To develop a model of nonalcoholic steatohepatitis induced by a methionine and choline deficient diet, as well as to evaluate the role of metformin, vitamin E and simvastatin in the nonalcoholic steatohepatitis progression. Methods -The study analyzed prospectively 50 Wistar rats for a 90-day period and divided them into five groups of 10 rats. One group was given standard rat diet and the others received the methionine and choline deficient diet. Among the four groups that received this diet, one received saline 0,9% and the others received metformin, vitamin E or simvastatin. After the study period, the animals were sacrificed and their blood was collected for biochemical analysis. The livers were removed for lipoperoxidation analysis and for the histological examinations. Results -The methionine and choline deficient diet was able to induce steatosis in 100% of the animals and nonalcoholic steatohepatitis in 27 (69.2%). The alanine aminotransferase levels were significantly higher in the simvastatin group. The aspartate aminotransferase levels were also higher in the simvastatin group, but were statistically significant only in relation to the standard diet group. When lipoperoxidation values were compared, the groups that received standard rat diet and methionine and choline deficient with vitamin E presented significantly lower rates than the others. The presence of fibrosis was significantly smaller in the group receiving vitamin E. Conclusions -The diet used was able to induce steatosis and nonalcoholic steatohepatitis. Besides vitamin E showed to reduce the liver oxidative stress, as well as the fibrosis development. HEADINGS -Vitamin E. Fatty liver. Rats.

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“…To date, atorvastatin, pravastatin, and rosuvastatin have been studied. An important point about these studies is that the statin doses were not equipotent nor comparable in their lipid lowering effect [64] .…”

Section: Statinsmentioning

confidence: 99%

Nonalcoholic Steatohepatitis in Children: The Modern Day Pediatric Epidemic

El‐Shabrawi

Issa

2015

Journal of Gastroenterology and Hepatology Research

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Ursodeoxycholic Acid and Atorvastatin in the Treatment of Nonalcoholic Steatohepatitis

Abstract: The use of atorvastatin in NASH patients with hyperlipidemia was found to be both effective and safe. The benefit of statin and UDCA therapy in normolipidemic patients with NASH requires confirmation with further placebo-controlled trials.

Cited by 181 publications

References 12 publications

Spectrum of Liver Disease in Type 2 Diabetes and Management of Patients With Diabetes and Liver Disease

Spectrum of Liver Disease in Type 2 Diabetes and Management of Patients With Diabetes and Liver Disease

The vitamin E reduces liver lipoperoxidation and fibrosis in a model of nonalcoholic steatohepatitis

Nonalcoholic Steatohepatitis in Children: The Modern Day Pediatric Epidemic

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