Ursodeoxycholic acid and COVID-19 outcomes: a cohort study and data synthesis of state-of-art evidence

Yu, Yang; Li, Guo-Fu; Li, Jian; Han, Lu-Yao; Zhang, Zhi-Long; Liu, Tian-Shuo; Jiao, Shu-Xin; Qiao, Yu-Wei; Zhang, Na; Zhan, De-Chuan; Tang, Shao-Qiu; Yu, Guo

doi:10.1080/14787210.2024.2376153

Expert Review of Anti-infective Therapy

2024

DOI: 10.1080/14787210.2024.2376153

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Ursodeoxycholic acid and COVID-19 outcomes: a cohort study and data synthesis of state-of-art evidence

Yang Yu,

Guo-Fu Li,

Jian Li

et al.

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2024

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Cited by 2 publications

References 38 publications

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The Potential Therapeutic Approach of Ursodeoxycholic Acid as a Potent Activator of ACE‐2 on Cerebral Disorders Induced by γ‐irradiation in Rats

Galal,

El kiki,

Elgazzar

2024

Cell Biochemistry & Function

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The present investigation assesses ursodeoxycholic acid's efficacy (UDCA) as an ACE2 activator against gamma irradiation through activating the renin‐angiotensin system's (RAS) beneficial axis, ACE2/Ang‐(1–7)/Mas1 via its profitable influence on inflammation, oxidative stress, and neuronal damage caused by irradiation (IRR). Four groups of rats were treated as follows: control group, group receiving UDCA (100 mg/kg/day) for 14 days by gavage, group irradiated at 6 Gy, and group receiving UDCA post‐irradiation for 14 days. The results revealed that gamma‐irradiation (6 Gy) caused a substantial drop in the cerebral ACE2/Ang‐(1–7)/Mas1 axis and remarkably increased the expression of cerebral inflammatory mediators: tumor necrosis factor‐α (TNF‐α), nuclear factor kappa‐B (NF‐κB), interleukin‐6 (IL‐6) and interleukin‐1β (IL‐1β) combined with significant elevation in cyclooxygenase‐II (COX‐II), (NADPH) oxidases (NOX4), lipooxygenase (LOX) activities and nitric oxide (NO) content. Moreover, it greatly enhanced the reduction in N‐methyl‐d‐aspartate (NMDA) level, while dramatically increasing gamma‐aminobutyric acid (GABA) level and neuronal nitric oxide synthases (nNOS) enzyme activity in cerebral tissue homogenate. Irradiated rats’ brain sections underwent histological investigation using hematoxylin and eosin staining, which revealed cellular damage and a pathological appearance. The administration of UDCA inverts these unusual alterations. In conclusion, UDCA treatment efficiently normalizes the above‐mentioned pathological abnormalities and avoids the development of IRR‐associated neurological dysfunction by upregulating the beneficial axis of RAS in the brain. Hence, ursodeoxycholic acid presents a novel option for patient care during radiotherapy.

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The Potential Therapeutic Approach of Ursodeoxycholic Acid as a Potent Activator of ACE‐2 on Cerebral Disorders Induced by γ‐irradiation in Rats

Galal,

El kiki,

Elgazzar

2024

Cell Biochemistry & Function

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Overall Mortality and Cardiovascular Mortality Associated With MAFLD+/NAFLD− Versus MAFLD−/NAFLD+: A Secondary Analysis

Gao,

Guan,

et al. 2024

Liver International

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Ursodeoxycholic acid and COVID-19 outcomes: a cohort study and data synthesis of state-of-art evidence

Cited by 2 publications

References 38 publications

The Potential Therapeutic Approach of Ursodeoxycholic Acid as a Potent Activator of ACE‐2 on Cerebral Disorders Induced by γ‐irradiation in Rats

The Potential Therapeutic Approach of Ursodeoxycholic Acid as a Potent Activator of ACE‐2 on Cerebral Disorders Induced by γ‐irradiation in Rats

Overall Mortality and Cardiovascular Mortality Associated With MAFLD+/NAFLD− Versus MAFLD−/NAFLD+: A Secondary Analysis

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