Ursolic acid analogues: non-phenolic functional food components in Jamaican raspberry fruits

Bowen‐Forbes, Camille S.; Mulabagal, Vanisree; Liu, Yun‐Bao; Nair, Muraleedharan G.

doi:10.1016/j.foodchem.2009.02.075

Cited by 35 publications

(29 citation statements)

References 23 publications

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“…The poor solubility of triterpenoids in aqueous assay conditions interferes with both LPO and COX assays. However, at lower concentrations compounds 1 and 2 showed moderate LPO and COX enzymes inhibitory activities which is in agreement with our earlier finding (Bowen-Forbes et al, 2009;Zhang, DeWitt, Murugesan, & Nair, 2009). …”

Section: Resultssupporting

confidence: 93%

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Pods of Khejri (Prosopis cineraria) consumed as a vegetable showed functional food properties

Liu

Singh²,

Nair

2012

Journal of Functional Foods

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Antioxidant Antiinflammatory Triterpenoids Piperidine alkaloids Phenolics A B S T R A C T The arid plant Prosopis cineraria (Fabaceae) is known as Khejri in India or the golden tree of Indian deserts. The dried pods are consumed as a vegetable and leaves as traditional medicine to cure a wide range of diseases in the state of Rajasthan, India. The pods of this plant have not been investigated for their bioactive components, hence we have done so in this study. The dried pods were boiled with water to afford the aqueous extract. Extraction of the residue gave methanolic extract. The lipid peroxidation (LPO) and cyclooxygenase enzymes (COX-1 and -2) inhibitory activities of extracts and major compounds present in the bioactive extracts were then determined. Purification of bioactive extracts yielded compounds 1-7. The absorbance of 1-7 at 570 nm ranged between 0.15 and 0.45 at 50 lg/mL whereas vitamin C and tert-butylhydroquinone (TBHQ) at 25 lg/mL gave an absorbance of 0.5 in the MTT [3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide] assay.At 25 lg/mL concentration, compounds 1-7 inhibited LPO, COX-1 and -2 enzymes between the ranges of 15-87%, 21-67% and 16-59%, respectively. This is the first report of the chemical and biological activities of the edible part of this plant.

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Section: Resultssupporting

confidence: 93%

“…Peroxidation of the lipid was initiated by adding ferrous ions. The OH radicals produced from the oxidation of the lipid then trigger the peroxidation of the embedded fluorescent probe (Bowen-Forbes, Mulabagal, Liu, & Nair, 2009). The water and methanolic extracts at 250 lg/mL showed LPO inhibition by 79% and 65%, respectively.…”

Section: Resultsmentioning

confidence: 99%

Pods of Khejri (Prosopis cineraria) consumed as a vegetable showed functional food properties

Liu

Singh²,

Nair

2012

Journal of Functional Foods

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“…Euscaphic acid, 1-b-hydroxyeuscaphic acid, and hyptatic acid B showed selective COX-1 enzyme inhibitory activity (13%, 25%, and 35% respectively) at 25 μg/mL. Similar COX inhibitory activity was demonstrated by compounds 4-epi-nigaichigoside F1 and trachelosperoside B-1, which showed moderate selectivity against the COX-1 enzyme [124]. In addition, the anti-inflammatory activity of Psidium cattleianum (strawberry guava) was analyzed using COX-1 and -2 enzyme inhibitory assays.…”

Section: Bioactivities Of Wild Fruitsmentioning

confidence: 90%

Bioactivities and Health Benefits of Wild Fruits

Wang

Zhang

et al. 2016

IJMS

131

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Wild fruits are exotic or underutilized. Wild fruits contain many bioactive compounds, such as anthocyanins and flavonoids. Many studies have shown that wild fruits possess various bioactivities and health benefits, such as free radical scavenging, antioxidant, anti-inflammatory, antimicrobial, and anticancer activity. Therefore, wild fruits have the potential to be developed into functional foods or pharmaceuticals to prevent and treat several chronic diseases. In the present article, we review current knowledge about the bioactivities and health benefits of wild fruits, which is valuable for the exploitation and utilization of wild fruits.

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“…Estupiñan [51] reported the presence of cyanidin-3-glucoside and cyanidin-3-rutinoside, cyanidin-3-sambubioside, cyanidin-3-xylosylrutinoside, pelargonidin-3-glucoside, and pelargonidin-3-rutinoside, cyanidin glycoside, lambertianin C and sanguiin H-6, and 2 ellagitannins in various Rubus species. Bowen-Forbes et al [52] reported the presence of…”

Section: Identification Of the Isolated Bioactive Compoundsmentioning

confidence: 99%

“…Based on the TLC, the fractions with similar banding pattern were clubbed and 16 fractions were obtained. The various fractions such as F1 (34)(35)(36)(37), F2 (38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50)(51)(52)(53)(54), F3 (55-58), F4 (59-72), F5 (76-80), F6 (84-88), F7 (89-110), F8 (111-116), F9 (121-126), F10 (132-136), F11 (137-141), F12 (142), F13 (143-147), F14 (148-151), F15 (159-162), and F16 (163-183) were subjected to antioxidant studies. The most active fractions such as F5, F7, F9, and F16 were selected for further isolation process.…”

Section: Chromatographic Separation Of the Root Acetone Extractmentioning

confidence: 99%

Bioassay Directed Isolation and Biological Evaluation of Compounds Isolated fromRubus fairholmianusGard.

George

Thangaraj

Sulaiman

et al. 2014

BioMed Research International

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The in vitro and in silico analysis of Rubus fairholmianus acetone extract for antioxidant, antiproliferative, and anti-inflammatory activity led to the isolation of six compounds. Amongst all the six isolated compounds tested, 1-(2-hydroxyphenyl)-4-methylpentan-1-one (compound 1) and 2-[(3-methylbutoxy) carbonyl] benzoic acid (compound 2) were found to be more active in inhibiting BRCA and COX target proteins, which also showed the better results for DPPH and ABTS radical scavenging assays. The promising results of this investigation emphasize the importance of using R. fairholmianus in the treatment of radical generated disorders mainly cancer and other inflammatory diseases.

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Ursolic acid analogues: non-phenolic functional food components in Jamaican raspberry fruits

Cited by 35 publications

References 23 publications

Pods of Khejri (Prosopis cineraria) consumed as a vegetable showed functional food properties

Pods of Khejri (Prosopis cineraria) consumed as a vegetable showed functional food properties

Bioactivities and Health Benefits of Wild Fruits

Bioassay Directed Isolation and Biological Evaluation of Compounds Isolated fromRubus fairholmianusGard.

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