Ursolic acid and oleanolic acid, members of pentacyclic triterpenoid acids, suppress TNF-α-induced E-selectin expression by cultured umbilical vein endothelial cells

Solid dispersions containing ursolic acid in Poloxamer 407 and PEG 6000: A comparative study of fusion and solvent methods

“…Several pharmacological effects have been attributed to this drug, including hepatoprotection [2], tumor inhibition [3,4], cardiovascular protection [5,6], enhancement of immune system [7], antioxidant [8], trypanocidal [9], antidiabetic [10][11][12], antiinflammatory [13] and osteoblast anabolic activities [14]. However, ursolic acid, a weak acid with pKa 5.29 [15], has a very low water solubility, which limits its bioavailability and therapeutic application [16].…”

Ursolic acid enhances pentobarbital-induced sleeping behaviors via GABAergic neurotransmission in mice

“…To date, several active components of P. vulgaris have been elucidated: rosmarinic acid, caffeic acid, ursolic acid, danshensu, and oleanolic acid (Feng et al, 2010). Interestingly, ursolic acid and oleanolic acid are well known triterpenoids, which perform many beneficial functions, such as anti-inflammatory and anti-oxidant actions (Liu, 1995, Tsai andYin, 2008), neuroprotection (Shih et al, 2004), and immunomodulatory effects (Takada et al, 2010). Specifically, ursolic acid has also been reported to have depressive and sedative activities, suggesting that it may be an effective candidate for GABA A receptor agonist-mediated therapeutics such as sleep disorders (Taviano et al, 2007).…”

Effects of Vasoactive Chinese Herbs on the Endothelial NO System

“…The reported effects of ursolic acid on atherogenesis are controversial. TNF-induced Eselectin expression is shown to be suppressed by ursolic acid via the inhibition of NF-B [50]. In the rat carotid artery injury model, ursolic acid has been demonstrated to inhibit neointima formation [51].…”