Urtica dioica-Derived Phytochemicals for Pharmacological and Therapeutic Applications

Taheri, Yasaman; Quispe, Cristina; Herrera‐Bravo, Jesús; Sharifi‐Rad, Javad; Ezzat, Shahira M.; Merghany, Rana M.; Shaheen, Shabnum; Azmi, Lubna; Mishra, Abhay Prakash; Şener, Bilge; Kılıç, Mehtap; Sen, Surjit; Acharya, Krishnendu; Nasiri, Azadeh; Cruz‐Martins, Natália; Fokou, Patrick Valère Tsouh; Ydyrys, Alibek; Bassygarayev, Zhandos; Daştan, Sevgi Durna; Alshehri, Mohammed M.; Calina, Daniela; Cho, William C.

doi:10.1155/2022/4024331

Cited by 68 publications

(51 citation statements)

References 116 publications

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“…Phytochemicals and similar derivative compounds have been shown to play an essential role as cancer treatment agents [2,[41][42][43]. The majority of protein kinase inhibitors found in plants are flavonoids, which are polyketides.…”

Section: Ras-erk and Natural Bioactive Compounds In Chemotherapy And ...mentioning

confidence: 99%

Targeting Ras-ERK cascade by bioactive natural products for potential treatment of cancer: an updated overview

Ali

Akter

Ramproshad³

et al. 2022

Cancer Cell Int

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MAPK (mitogen-activated protein kinase) or ERK (extracellular-signal-regulated kinase) pathway is an important link in the transition from extracellular signals to intracellular responses. Because of genetic and epigenetic changes, signaling cascades are altered in a variety of diseases, including cancer. Extant studies on the homeostatic and pathologic behavior of MAPK signaling have been conducted; however, much remains to be explored in preclinical and clinical research in terms of regulation and action models. MAPK has implications for cancer therapy response, more specifically in response to experimental MAPK suppression, compensatory mechanisms are activated. The current study investigates MAPK as a very complex cell signaling pathway that plays roles in cancer treatment response, cellular normal conduit maintenance, and compensatory pathway activation. Most MAPK inhibitors, unfortunately, cause resistance by activating compensatory feedback loops in tumor cells and tumor microenvironment components. As a result, innovative combinatorial treatments for cancer management must be applied to limit the likelihood of alternate pathway initiation as a possibility for generating novel therapeutics based on incorporation in translational research. We summarize current knowledge about the implications of ERK (MAPK) in cancer, as well as bioactive products from plants, microbial organisms or marine organisms, as well as the correlation with their chemical structures, which modulate this pathway for the treatment of different types of cancer.

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Section: Ras-erk and Natural Bioactive Compounds In Chemotherapy And ...mentioning

confidence: 99%

Targeting Ras-ERK cascade by bioactive natural products for potential treatment of cancer: an updated overview

Ali

Akter

Ramproshad³

et al. 2022

Cancer Cell Int

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“…As plant-based drug development is advancing due to its proven efficacy and cost-effectiveness, plant alkaloids are the most promising. For the discovery of new natural product-based chemopreventive agents, a judicious selection and a holistic approach for the selection of compound (individual or group), plant source, and plant part are pivotal [ 18 , 140 , 141 ]. In the scenario of tremendous anthropogenic pressure on natural plant resources and many plant resources coming into the category of “Rare” or “Endangered”, the task of getting the natural compounds becomes a tough job though [ 142 ].…”

Section: Design and Development Of Anticancer Agents Based On Natural...mentioning

confidence: 99%

Anticancer potential of alkaloids: a key emphasis to colchicine, vinblastine, vincristine, vindesine, vinorelbine and vincamine

et al. 2022

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Cancer, one of the leading illnesses, accounts for about 10 million deaths worldwide. The treatment of cancer includes surgery, chemotherapy, radiation therapy, and drug therapy, along with others, which not only put a tremendous economic effect on patients but also develop drug resistance in patients with time. A significant number of cancer cases can be prevented/treated by implementing evidence-based preventive strategies. Plant-based drugs have evolved as promising preventive chemo options both in developing and developed nations. The secondary plant metabolites such as alkaloids have proven efficacy and acceptability for cancer treatment. Apropos, this review deals with a spectrum of promising alkaloids such as colchicine, vinblastine, vincristine, vindesine, vinorelbine, and vincamine within different domains of comprehensive information on these molecules such as their medical applications (contemporary/traditional), mechanism of antitumor action, and potential scale-up biotechnological studies on an in-vitro scale. The comprehensive information provided in the review will be a valuable resource to develop an effective, affordable, and cost effective cancer management program using these alkaloids.

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“…Despite numerous advances in cancer treatment, it is still a life-threatening disease [171][172][173]. Today, natural compounds due to their predictable function, high therapeutic potential and low toxicity, are significant in preventing various types of cancer [174,175]. Flavonoids derived from fruits and vegetables are known to be important compounds because of their positive effects on cancer prevention [176].…”

Section: Therapeutic Perspectivesmentioning

confidence: 99%

Potential mechanisms of quercetin in cancer prevention: focus on cellular and molecular targets

et al. 2022

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Over the past few years, the cancer-related disease has had a high mortality rate and incidence worldwide, despite clinical advances in cancer treatment. The drugs used for cancer therapy, have high side effects in addition to the high cost. Subsequently, to reduce these side effects, many studies have suggested the use of natural bioactive compounds. Among these, which have recently attracted the attention of many researchers, quercetin has such properties. Quercetin, a plant flavonoid found in fresh fruits, vegetables and citrus fruits, has anti-cancer properties by inhibiting tumor proliferation, invasion, and tumor metastasis. Several studies have demonstrated the anti-cancer mechanism of quercetin, and these mechanisms are controlled through several signalling pathways within the cancer cell. Pathways involved in this process include apoptotic, p53, NF-κB, MAPK, JAK/STAT, PI3K/AKT, and Wnt/β-catenin pathways. In addition to regulating these pathways, quercetin controls the activity of oncogenic and tumor suppressor ncRNAs. Therefore, in this comprehensive review, we summarized the regulation of these signalling pathways by quercetin. The modulatory role of quercetin in the expression of various miRNAs has also been discussed. Understanding the basic anti-cancer mechanisms of these herbal compounds can help prevent and manage many types of cancer.

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Urtica dioica-Derived Phytochemicals for Pharmacological and Therapeutic Applications

Cited by 68 publications

References 116 publications

Targeting Ras-ERK cascade by bioactive natural products for potential treatment of cancer: an updated overview

Targeting Ras-ERK cascade by bioactive natural products for potential treatment of cancer: an updated overview

Anticancer potential of alkaloids: a key emphasis to colchicine, vinblastine, vincristine, vindesine, vinorelbine and vincamine

Potential mechanisms of quercetin in cancer prevention: focus on cellular and molecular targets

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