Urticaria Pigmentosa Appearing as a Solitary Nodular Lesion

Chargin, Louis; Sachs, Perry M.

doi:10.1001/archderm.1954.01540150091008

Cited by 32 publications

(8 citation statements)

References 2 publications

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“…In the literature, adult cases of this type have also been observed (14,15). Generally, only slight basal melanosis has been reported in the single nodular type (16). The result of the present analyses of the basal melanosis in solitary nodular cases supports this observation.…”

Section: Discussionsupporting

confidence: 83%

A Clinical and Histological Study of Urticaria Pigmentosa: Relationships between Mast Cell Proliferation and the Clinical and Histological Manifestations

Akiyama

1990

The Journal of Dermatology

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In 21 cases of urticaria pigmentosa (UP), clinical and histological observations and evaluation of mast cell (MC) volume density in the lesions using a morphometric point counting method were performed. The mutual correlations between clinical and histological findings were statistically assessed by a method of multiple regression analysis. Clinical items employed in the analyses were as follows: sex, the age of onset, the age of biopsy, the biopsy, the duration of lesions, the type of skin lesions, sites involved, the presence or absence of Darier's sign of Darier's sign and symptoms, and serum histamine level. Histological items included the localization and infiltration pattern of MC, the level of basal melanosis, the presence or absence of inflammatory cell infiltration, and the MC volume density in the lesions. Statistical significance of the partial regression coefficients was obtained for 6 pairs of the criteria (p = 0.05), including the age of onset and the age of biopsy, the age of onset and the level of basal melanosis, the duration of lesions and the level of basal melanosis, and the type of skin lesions and the level of basal melanosis. No significant correlations were observed between the MC volume density in the lesions and any of the other items. These results suggest that the basal melanosis in a UP lesion may not be a direct reaction to the transitory massive infiltration of MC, but rather be due to a relatively long-term effect of MC infiltration. Furthermore, the MC volume density in the lesion is not likely to be an important factor in determining the clinical manifestations of a UP lesion.

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Section: Discussionsupporting

confidence: 83%

A Clinical and Histological Study of Urticaria Pigmentosa: Relationships between Mast Cell Proliferation and the Clinical and Histological Manifestations

Akiyama

1990

The Journal of Dermatology

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“…These patients, mostly children, are classified as cutaneous mastocytosis (CM) and have a good prognosis (5). A localized form of CM, termed mastocytoma of skin, has also been described (6,7). Overall, the basic classification of mastocytosis into cutaneous and systemic remains valid.…”

Section: Introduction and Historical Overviewmentioning

confidence: 99%

Advances in the Classification and Treatment of Mastocytosis: Current Status and Outlook toward the Future

et al. 2017

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Mastocytosis is a term used to denote a heterogeneous group of conditions defined by expansion and accumulation of clonal (neoplastic) tissue mast cells in various organs. The classification of the World Health Organization (WHO) divides the disease into cutaneous mastocytosis (CM), systemic mastocytosis (SM), and localized mast cell tumors. Based on histomorphologic criteria, clinical parameters, and organ involvement, SM is further divided into indolent SM (ISM) and advanced SM variants, including aggressive SM (ASM) and mast cell leukemia (MCL). The clinical impact and prognostic value of this classification has been confirmed in numerous studies, and its basic concept remains valid. However, refinements have recently been proposed by the consensus group, the WHO, and the European Competence Network on Mastocytosis (ECNM). In addition, new treatment options are available for patients with advanced SM, including allogeneic hematopoietic stem cell transplantation and multi-kinase inhibitors directed against KIT D816V and other key signalling molecules. Our current article provides an overview of recent advances in the field of mastocytosis, with emphasis on classification, prognostication, and emerging new treatment options in advanced SM.

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“…It usually appears in babies, before their sixth month, as single or, rarely, multiple rounded or oval hyperpigmented macular, tuberous or nodular lesions. Over a period of several months they gradually grow up to 4 cm in diameter; then the lesions stabilize and tend to regress for as long as up to 7 years 1–4 . Spontaneous total regression is the natural course in 25% of mastocytoma cases.…”

Section: To the Editormentioning

confidence: 99%

Mastocytoma: topical corticosteroid treatment

Mateo¹

2001

Acad Dermatol Venereol

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Urticaria Pigmentosa Appearing as a Solitary Nodular Lesion

Cited by 32 publications

References 2 publications

A Clinical and Histological Study of Urticaria Pigmentosa: Relationships between Mast Cell Proliferation and the Clinical and Histological Manifestations

A Clinical and Histological Study of Urticaria Pigmentosa: Relationships between Mast Cell Proliferation and the Clinical and Histological Manifestations

Advances in the Classification and Treatment of Mastocytosis: Current Status and Outlook toward the Future

Mastocytoma: topical corticosteroid treatment

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