Urticarial exanthem associated with Capnocytophaga canimorsus bacteremia after a dog bite

Jordan, Christian S.; Miniter, Una; Yarbrough, Kevin B.; Mengden, Stephanie

doi:10.1016/j.jdcr.2015.12.007

Cited by 11 publications

(17 citation statements)

References 20 publications

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“…Ayrıca ısırık bölgesinde nekrotizan kabuk ile karakterizedir (14). Jordan ve ark, sokakta yaşayan evsiz ve 59 yaşında alkolik, sağ total diz artroplastisi ve tip 2 diyabet geçmişi olan bir erkek hastada, bir gündür kötüleşen sağ diz ağrısı, deride döküntü, subjektif ateş ve generalize ağrı belirlemişlerdir (15). Uyluk bölgesinde çoklu, dağınık peteşiler olan hastanın üç hafta önce kendisine ait ve aşılanmış köpeği ile oynarken sağ elinden ısırıldığı ve yaraları sabun ve suyla yıkadığı bilgisi de verilmektedir.…”

Section: öZtürk Ve Köseunclassified

Hidden Threat: Flesh-Eating Zoonotic Bacteria

Öztürk

Köse

2019

Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi

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ÖzNekrotizan fasiit, hem insanlarda hem de hayvanlarda yumuşak dokuların hızla ölümüne sebep olabilen ve bazen daha derin dokulara kadar ilerleyebilen bakteriyel bir deri hastalığıdır. Bu bakterilerden bazıları yalnızca insanlarda enfeksiyona neden olur iken bir kısım bakteride hayvanlarla ya da su canlıları ile bütünlüğü bozulmuş deri ile temas halinde ya da ısırık/çizikler vasıtası ile vücuda alınıp nekrotizan fasiite sebep olabilen zoonoz etkenlerdir. Nekrotizan fasiit' e neden olan zoonoz karakterli bakteriler hakkında pek çok vaka takdimi yapılmıştır. Enfeksiyonun tanımlanmasında hastanın mutlaka detaylı hikayesi dinlenmeli herhangi bir temas ile karşı karşıya kalındığında yara bakımının yapılmasına ek olarak sistemik tedavi girişimlerinde de bulunulmalıdır. Aksi takdirde hastanın genel sağlık durumuna göre uzuvlarda kayıplar, septisemi ve çoklu organ yetmezliklerine kadar ilerleyebilen ciddi bir hastalık tablosu meydana gelmekte ve böyle vakaların çoğu da ölüm ile sonuçlanmaktadır. Bu derlemenin amacı, hayvanlardan insanlara temas ile bulaşabilen ve nekrotizan fasiite sebep olan etkenler hakkında bilgi vermek ve hem veteriner hekimleri hem de hayvan sahipleri/severlerinin farkındalıklarını artırmaktır. AbstractIn both human and animals, necrotizing fasciitis is a bacterial integumentary disease causing fulminant soft tissue death and tending to spread into the depth tissue. While some of these bacteria cause infections only in human, a part of these bacteria infecting to human with contact to erupted skin or bites and scratch by animals or aquatic animals are the zoonotic agents of Necrotizing fasciitis. Many case studies on zoonotic bacteria causing necrotizing fasciitis have been reported. In the diagnosis of infection, the patient's detailed history should be taken and the patient should be treated with systemic treatment interventions, in addition to the wound care in exposing of any contact. Otherwise, according to the general health status of the patient, severe diseases progressing to loss of limbs, septicemia, and multiple organ deficiencies occur and also the most of these cases result in death. The aim of this review is to provide information about causative agents of necrotizing fasciitis that can be transmitted by contact from animals to humans, and to raise awareness of both veterinarians and animal owners or lovers.

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Section: öZtürk Ve Köseunclassified

Hidden Threat: Flesh-Eating Zoonotic Bacteria

Öztürk

Köse

2019

Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi

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“…While C. canimorsus is a rare cause of illness in humans, it can present with severe clinical manifestations and is often fatal [4]. About half of patients infected with C. canimorsus have dermatologic findings [5]. We describe a case of C. canimorsus bacteremia that followed a relatively indolent course and was associated with an urticarial exanthem.…”

Section: Introductionmentioning

confidence: 99%

Capnocytophaga canimorsus Bloodstream Infection Associated with an Urticarial Exanthem

Goetzinger

LaGrow

Shibib

et al. 2021

Case Reports in Infectious Diseases

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Background. Capnocytophaga canimorsus is a fastidious, slow-growing, Gram-negative rod that is a commensal bacterium in normal gingival flora of canine and feline species. Infection with the organism may cause disease ranging from flu-like symptoms to disseminated intravascular coagulation (DIC), fulminant sepsis, meningitis, and endocarditis with an overall fatality rate of 6–26%. Risk factors for infection from C. canimorsus include immunosuppression, alcoholism, and asplenia. Case Presentation. We describe an unusual case with a relatively indolent clinical course and an urticarial exanthem in an otherwise young immunocompetent patient with a history of type 1 diabetes. The patient presented to the Emergency Department (ED) with a <1-day history of rhinorrhea, fever, and dyspnea. He met sepsis criteria on initial presentation, but left against medical advice and returned to the ED the following day, with new arthralgias and a diffuse rash, multiple erythematous, tender macules scattered across his trunk and extremities, and tonsillar erythema. He had not taken the doses of the prescribed amoxicillin. Blood cultures two days later signaled positive for growth with the Gram stain showing a Gram-negative rod. Three 7-8 cm tender targetoid lesions with central clearing were identified on the patient’s back. The patient reported two nonengorged ticks crawling on his body a week prior and sustaining a dog bite to his ear three weeks before presentation. Ultimately, the organism was identified as C. canimorsus through MALDI-TOF mass spectrometry and additional biochemical testing. He was given appropriate antibiotics and improved clinically thereafter. Despite the patient’s bacteremia, he never progressed to fulminant sepsis and followed a mild clinical course with several unusual characteristics. C. canimorsus is an uncommon cause of illness in humans, but is an important pathogen to consider when evaluating a patient with a dog bite, known risk factors, and an urticarial exanthem as empiric treatment may prevent severe outcomes.

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“…The prevalence is relatively higher among immunocompromised patients, especially with splenectomy and alcoholism. However, canine exposure is a key variable to consider as about 60% of the patients demonstrate a history of dog bite while others confirm having scratches from dogs or occasionally cats, or even a benign exposure to dogs without bites or scratches 2…”

Section: Introductionmentioning

confidence: 99%

“…To the best of our knowledge, approximately 500 cases of C. canimorsus infection have been reported in the medical literature as of October 2018 2. However, only two patients who both had a history of splenectomy, presented with predominant clinical features of acute abdomen 5 6.…”

Section: Introductionmentioning

confidence: 99%

Capnocytophaga canimorsus-associated sepsis presenting as acute abdomen: do we need to think outside the box?

Ahmad

Yousaf

Inayat³

et al. 2019

BMJ Case Rep

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Capnocytophaga canimorsus is a commensal bacterium commonly found in the oral cavity of dogs and cats. Although this organism rarely causes infection, prompt diagnosis is crucial for survival of these patients. Several unusual clinical presentations of this infection have been reported in the published medical literature. The present report represents the first case of C. canimorsus-related sepsis presenting with symptoms of acute abdomen in a patient with no known history of immunodeficiency. Prompt aggressive care and appropriate antibiotic therapy resulted in a successful clinical outcome with no long-term morbidity. This paper illustrates that clinicians should include this infectious aetiology among the differentials of patients presenting with acute abdomen, regardless of their immune status. Additionally, this paper outlines our current understanding of the epidemiology of and risk factors for C. canimorsus-associated sepsis, the pathophysiology of this disorder, and currently available approaches to diagnosis and management.

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Urticarial exanthem associated with Capnocytophaga canimorsus bacteremia after a dog bite

Cited by 11 publications

References 20 publications

Hidden Threat: Flesh-Eating Zoonotic Bacteria

Hidden Threat: Flesh-Eating Zoonotic Bacteria

Capnocytophaga canimorsus Bloodstream Infection Associated with an Urticarial Exanthem

Capnocytophaga canimorsus-associated sepsis presenting as acute abdomen: do we need to think outside the box?

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