US Biomedical Research

Zerhouni, Elias A.

doi:10.1001/jama.294.11.1352

Cited by 225 publications

(53 citation statements)

References 21 publications

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“…Therefore, these results can be viewed as uncontrolled. However, there is support for a practice-based approach [64,65] to determine the effectiveness of new treatments for disorders of unknown etiology.…”

Section: Clinical Seriesmentioning

confidence: 99%

A Perspective on Recurrent Vertigo

Gacek

2013

ORL

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The recurrent nature of the 3 most common vestibulopathies suggests a recurrent cause. Histopathology in temporal bones from patients with these syndromes - vestibular neuronitis (VN, n = 7), Ménière's disease (MD, n = 8) and benign paroxysmal positional vertigo (BPPV, n = 5) - shows focal degeneration of vestibular nerve axons and degenerated nearby facial nerve meatal ganglion cells. Transmission electron microscopic confirmation of intracytoplasmic viral particles in surgically excised vestibular nerves from patients with VN and MD support a viral etiology in these vestibulopathies. Antiviral treatment of these syndromes in a series of 211 patients with a 3- to 8-year follow-up resulted in complete control of vertigo in VN (88%), MD (90%) and BPPV (60%).

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Section: Clinical Seriesmentioning

confidence: 99%

A Perspective on Recurrent Vertigo

Gacek

2013

ORL

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“…The focus of much rat research and of federally sponsored biomedical research as a whole is translational medicine (15), the application of basic research to address problems in human health. RGD has been supporting this trend through an emphasis on comparative mapping resources and tools (16) and most recently through the disease portals.…”

Section: Discussion and Future Directionsmentioning

confidence: 99%

The Rat Genome Database, update 2007--Easing the path from disease to data and back again

Twigger¹,

Shimoyama²,

Bromberg³

et al. 2007

Nucleic Acids Research

116

114

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The Rat Genome Database (RGD, ) is one of the core resources for rat genomics and recent developments have focused on providing support for disease-based research using the rat model. Recognizing the importance of the rat as a disease model we have employed targeted curation strategies to curate genes, QTL and strain data for neurological and cardiovascular disease areas. This work has centered on rat but also includes data for mouse and human to create ‘disease portals’ that provide a unified view of the genes, QTL and strain models for these diseases across the three species. The disease curation efforts combined with normal curation activities have served to greatly increase the content of the database, particularly for biological information, including gene ontology, disease, pathway and phenotype ontology annotations. In addition to improving the features and database content, community outreach has been expanded to demonstrate how investigators can leverage the resources at RGD to facilitate their research and to elicit suggestions and needs for future developments. We have published a number of papers that provide additional information on the ontology annotations and the tools at RGD for data mining and analysis to better enable researchers to fully utilize the database.

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“…In addition, the electronic medical record provides increased opportunities for data sharing. As previously stated by Elias Zerhouni, the former Director of NIH In this genomic age, the rapid development of genome-related technologies and the massive increase in research data have begun to enable multidimensional studies of complex but common diseases and are forcing scientists to re-evaluate current strategies for staging biomedical research (17). …”

Section: Establishing Future Hypertension Research Funding Prioritiesmentioning

confidence: 99%

“…In this genomic age, the rapid development of genome-related technologies and the massive increase in research data have begun to enable multidimensional studies of complex but common diseases and are forcing scientists to re-evaluate current strategies for staging biomedical research (17). …”

Section: Establishing Future Hypertension Research Funding Prioritiesmentioning

confidence: 99%

Establishing Funding Priorities for Hypertension Research

Kotchen

2017

Hypertension

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US Biomedical Research

Cited by 225 publications

References 21 publications

A Perspective on Recurrent Vertigo

A Perspective on Recurrent Vertigo

The Rat Genome Database, update 2007--Easing the path from disease to data and back again

Establishing Funding Priorities for Hypertension Research

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