US Renal Data System 2011 Annual Data Report

Collins, Allan J.; Foley, Robert N.; Chavers, Blanche M.; Gilbertson, David T.; Herzog, Charles A.; Johansen, Kirsten L.; Kasiske, Bertram L.; Kutner, Nancy G.; Liu, Jiannong; Peter, Wendy L. St.; Guo, Haifeng; Gustafson, S. K.; Heubner, Brooke; Lamb, Kenneth; Li, Shuling; Li, Suying; Peng, Yi; Qiu, Yang; Roberts, Tricia; Skeans, M. A.; Snyder, Jon J.; Solid, Craig A.; Thompson, Bryn; Wang, Changchun; Weinhandl, Eric D.; Zaun, David; Arko, Cheryl; Chen, Shu‐Cheng; Daniels, Frank; Ebben, James; Frazier, Eric; Hanzlik, Christopher; Johnson, Roger N.; Sheets, Daniel; Wang, Xinyue; Forrest, Beth; Constantini, Edward; Everson, Susan; Eggers, Paul W.; Agodoa, Lawrence

doi:10.1053/j.ajkd.2011.11.015

Cited by 541 publications

(217 citation statements)

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“…The immune defect in ESRD patients is associated with a reduced T-cell stimulation, leading to a high susceptibility for infectious complications [2][3][4][5]22]. This impaired T-cell activation is related to an impaired co-stimulation by APC.…”

Section: Discussionmentioning

confidence: 99%

Differentiation of Monocyte Derived Dendritic Cells in End Stage Renal Disease is Skewed Towards Accelerated Maturation

Dopheide¹,

Zeller²,

Kuhlmann³

et al. 2015

Adv Clin Exp Med

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Background. Dendritic cells (DC) play an important role in the induction of immune responses. Patients with end stage renal disease (ESRD) suffer from chronic inflammation, leading to a secondary, uremic immunodeficiency associated with alterations in monocyte subpopulations with increased proinflammatory capacities. Objectives. The aim of this study was to examine, under isolated conditions, whether alterations in monocyte subpopulations may affect in vitro maturation of dendritic cells (DC) in patients with ESRD, thus allowing us to draw conclusions for the situation in vivo. Material and Methods. Monocytes from 30 patients undergoing hemodialysis (HD) and 15 healthy volunteers were enriched from peripheral blood leukocytes, differentiated into immature DC (iDC) in medium containing IL-4 and GM-CSF, and were induced with LPS to differentiate into mature DC (mDC). Monocyte subpopulations and DC maturation stages were phenotypically characterized using flow-cytometry. Results. Although phenotypically indistinguishable, the number of both iDC and mDC that were generated from uremic monocytes was significantly higher compared to those from healthy controls (p = 0.02 and p = 0.03, respectively). This was associated with an increased number of CD14+ CD16+ monocytes (p = 0.02) and by a higher maturation efficiency of mDC in patients (p = 0.04). Conclusions. A high percentage of CD14+ CD16+ monocytes in patients with ESRD is associated with an increased propensity to differentiate into DC. This indicates that chronic inflammation may substantiate the biased consistence of monocyte subpopulations leading to profound alteration in DC generation and maturation in ESRD (Adv Clin Exp Med 2015, 24, 2, 257-266).

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Section: Discussionmentioning

confidence: 99%

Differentiation of Monocyte Derived Dendritic Cells in End Stage Renal Disease is Skewed Towards Accelerated Maturation

Dopheide¹,

Zeller²,

Kuhlmann³

et al. 2015

Adv Clin Exp Med

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“…Cardiovascular disease (CVD) is a leading cause of mortality and accounts for 39% of overall deaths in ESRD (1). The ability to identify patients at risk for death and prescribe therapy to reduce CVD risk is of considerable significance in the care of patients with ESRD.…”

Section: Introductionmentioning

confidence: 99%

Parathyroidectomy and Heart Rate Variability in Patients with Stage 5 CKD

Zhang

Sun

et al. 2013

Clinical Journal of the American Society of Nephrology

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SummaryBackground and objectives Lower heart rate variability implies increased risk of cardiovascular disease. This study aimed to evaluate the relationship between mineral metabolism and heart rate variability and longitudinal changes of heart rate variability after parathyroidectomy in stage 5 CKD patients.Design, setting, participants, & measurements This cross-sectional study included 118 stage 5 CKD patients, 87 controls, and a prospective study in two subgroups classified as successful (n=17) and unsuccessful (n=4) parathyroidectomy follow-up enrolled from March of 2011 to December of 2012. Blood examination and 24-hour Holter for heart rate variability were measured.Results Most heart rate variability indices were lower in stage 5 CKD patients. In multivariate stepwise regression models, serum intact parathyroid hormone was correlated with mean normal-to-normal R-R intervals, mean heart rate, and very low frequency, serum calcium was correlated with SD of 5-minute average of normal R-R intervals, and serum phosphorus was correlated with very low frequency and low frequency/high frequency. Compared with baseline, the successful parathyroidectomy subgroup had significant improvements in mean normal-to-normal R-R intervals, mean heart rate, SD of normal-to-normal R-R intervals, SD of 5-minute average of normal R-R intervals, very low frequency, high frequency, and low frequency/high frequency. There was no significant change of heart rate variability in patients after unsuccessful parathyroidectomy.Conclusions Disorders of mineral metabolism are associated with decreased heart rate variability in stage 5 CKD. Successful parathyroidectomy may contribute to reverse this cardiovascular disease risk in severe secondary hyperparathyroidism patients.

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“…Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disease (1:400-1:1000 births) and the fourth most single cause of end-stage renal disease (ESRD; Collins et al 2012). It is characterized by the development of kidney cysts that generally initiate from a tubule (Grantham 2008).…”

Section: Autosomal Dominant Polycystic Kidney Diseasementioning

confidence: 99%

Insights into autosomal dominant polycystic kidney disease by quantitative mass spectrometry-based proteomics

Diedrich

Dengjel

2017

Cell Tissue Res

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Autosomal dominant polycystic kidney disease (ADPKD) is a common monogenetic disorder that is caused by mutations in the genes PKD1 and PKD2 encoding polycystin-1 and polycystin-2, respectively. Polycystin-1 and -2 form a complex, interact with several proteins involved in signal transduction and localize to discrete subcellular positions, most importantly the primary cilium. Whereas the causative mutations leading to ADPKD are known, the underlying deregulated cellular pathways are not well understood. In the current review, we introduce state-of-the-art mass spectrometry (MS)-based proteomic techniques and summarize their use in kidney and ADPKD research. Proteomic profiling approaches, the elucidation of ADPKD-relevant proteinprotein interactions and the regulation of posttranslational modifications are included. We also discuss the use of MS-based methods for ADPKD prognosis, diagnosis and disease monitoring by using protein-and peptide-based biomarkers.

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US Renal Data System 2011 Annual Data Report

Cited by 541 publications

References 0 publications

Differentiation of Monocyte Derived Dendritic Cells in End Stage Renal Disease is Skewed Towards Accelerated Maturation

Differentiation of Monocyte Derived Dendritic Cells in End Stage Renal Disease is Skewed Towards Accelerated Maturation

Parathyroidectomy and Heart Rate Variability in Patients with Stage 5 CKD

Insights into autosomal dominant polycystic kidney disease by quantitative mass spectrometry-based proteomics

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