In the 21st century, the One Health approach recognizes the interdependence between human, animal and plant health and environmental conservation. In a globalized world where boundaries are blurring, this approach has become essential to address challenges such as zoonotic diseases, environmental degradation and food security. One Health fosters collaboration between public health, animal health, plant health and environmental conservation. Its implementation requires the cooperation of governments, NGOs, the private sector and civil society. Challenges include the lack of a common data platform and the need for sound legislation. Data collection and scientific evidence are essential, as is consideration of sociological factors in health. Social and technological innovation also play a crucial role. One Health offers the opportunity to comprehensively address public and environmental health issues, seeking a healthier and more equitable world for all species.