Usage of fMRI for pre-surgical planning in brain tumor and vascular lesion patients: Task and statistical threshold effects on language lateralization

Nadkarni, Tanvi; Andreoli, Matthew J.; Nair, Veena A.; Yin, Peng; Young, Brittany M.; Kundu, Bornali; Pankratz, Joshua; Radtke, Andrew; Holdsworth, Ryan; Kuo, John S.; Field, Aaron S.; Başkaya, Mustafa K.; Crönlein, Moritz; Meyerand, M. Elizabeth; Prabhakaran, Vivek

doi:10.1016/j.nicl.2014.12.014

Cited by 38 publications

(39 citation statements)

References 25 publications

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“…Due to the denominator term (LI1 + LI2), cases where LI's are of opposite signs, have larger variability in LI. Our current study found that LI VAR has a task‐dependence, similar to the findings by Nadkarni et al () who explored laterality within expressive versus receptive language tasks. Similarly, our study suggests that LI variability has a threshold‐dependence which is similar to the findings by Ruff et al ().…”

Section: Discussionsupporting

confidence: 90%

Repeatability of language fMRI lateralization and localization metrics in brain tumor patients

Agarwal

Hua

Sair

et al. 2018

Human Brain Mapping

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To assess the within-subject intra-scan session repeatability of language functional MRI (fMRI) activation maps in patients with brain tumors who were undergoing presurgical fMRI as part of their preoperative clinical workup. Sentence completion (SC) and silent word generation (SWG) tasks were used for language localization and hemispheric lateralization for identifying the primary language cortex. Within-subject repeatability for each of these paradigms was assessed in right-handed patients—37 for SC and 78 for SWG. Repeatability of activation maps between consecutive runs of the same task within the same scan session was evaluated by comparing lateralization indexes in holohemispheric and regional language areas. Displacement of center of activation between consecutive runs was also used to assess the repeatability of activation maps. Holohemispheric and regional language lateralization results demonstrated high intrasubject intra-scan repeatability when lateralization indices were calculated using thresholddependent and threshold-independent approaches. The high repeatability is demonstrated both when centers of mass of activation are considered within key eloquent regions of the brain, such as Broca’s area and Wernicke’s area, as well as in larger more inclusive expressive and receptive language regions. We examined two well-known and widely accepted language tasks that are known to activate eloquent language cortex. We have demonstrated very high degree of repeatability at a single-subject level within single scan sessions of language mapping in a large cohort of brain tumor patients undergoing presurgical fMRI across several years at our institution.

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Section: Discussionsupporting

confidence: 90%

Repeatability of language fMRI lateralization and localization metrics in brain tumor patients

Agarwal

Hua

Sair

et al. 2018

Human Brain Mapping

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show abstract

“…fMRI can be used to for sensory motor, language, and memory mapping—all of which have important implications for presurgical planning and intraoperative navigation. 95–97 …”

Section: Presurgical Planning Techniquesmentioning

confidence: 99%

Current Clinical Brain Tumor Imaging

2017

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Neuroimaging plays an ever evolving role in the diagnosis, treatment planning, and post-therapy assessment of brain tumors. This review provides an overview of current magnetic resonance imaging (MRI) methods routinely employed in the care of the brain tumor patient. Specifically, we focus on advanced techniques including diffusion, perfusion, spectroscopy, tractography, and functional MRI as they pertain to noninvasive characterization of brain tumors and pretreatment evaluation. The utility of both structural and physiological MRI in the post-therapeutic brain evaluation is also reviewed with special attention to the challenges presented by pseudoprogression and pseudoresponse.

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“…Multiple studies have documented the dependence of the LI obtained on the threshold chosen (Rutten et al, 2002; Adcock et al, 2003; Seghier et al, 2004; Abbott et al, 2010; Nadkarni et al, 2015). As illustrated in Fig.…”

Section: Introductionmentioning

confidence: 99%

Methodological considerations in assessment of language lateralisation with fMRI: a systematic review

Bradshaw

Bishop

Woodhead

2017

PeerJ

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The involvement of the right and left hemispheres in mediating language functions has been measured in a variety of ways over the centuries since the relative dominance of the left hemisphere was first known. Functional magnetic resonance imaging (fMRI) presents a useful non-invasive method of assessing lateralisation that is being increasingly used in clinical practice and research. However, the methods used in the fMRI laterality literature currently are highly variable, making systematic comparisons across studies difficult. Here we consider the different methods of quantifying and classifying laterality that have been used in fMRI studies since 2000, with the aim of determining which give the most robust and reliable measurement. Recommendations are made with a view to informing future research to increase standardisation in fMRI laterality protocols. In particular, the findings reinforce the importance of threshold-independent methods for calculating laterality indices, and the benefits of assessing heterogeneity of language laterality across multiple regions of interest and tasks. This systematic review was registered as a protocol on Open Science Framework: https://osf.io/hyvc4/.

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Usage of fMRI for pre-surgical planning in brain tumor and vascular lesion patients: Task and statistical threshold effects on language lateralization

Cited by 38 publications

References 25 publications

Repeatability of language fMRI lateralization and localization metrics in brain tumor patients

Repeatability of language fMRI lateralization and localization metrics in brain tumor patients

Current Clinical Brain Tumor Imaging

Methodological considerations in assessment of language lateralisation with fMRI: a systematic review

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